Variations in hip shape are associated with radiographic knee osteoarthritis: Cross-sectional and longitudinal analyses of the johnston county osteoarthritis project

Amanda E. Nelson, Yvonne M. Golightly, Jordan B. Renner, Todd A. Schwartz, Felix Liu, John A. Lynch, Jenny S. Gregory, Richard M. Aspden, Nancy E. Lane, Joanne M. Jordan

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Abstract

Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints. Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ? 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ? 2), and progressive knee rOA (KL increase of ? 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations. Results.We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA. Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA. The Journal of Rheumatology.

LanguageEnglish (US)
Pages405-410
Number of pages6
JournalJournal of Rheumatology
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2016

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Knee Osteoarthritis
Osteoarthritis
Hip
Cross-Sectional Studies
Knee Replacement Arthroplasties
Hip Osteoarthritis
Knee
Body Mass Index
Extremities
Logistic Models
Rheumatology
Pelvis
Femur
Arthritis
Joints

Keywords

  • Hip joint
  • Knee osteoarthritis
  • Radiography

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

@article{4af906182e9647eca430a4bf44898de4,
title = "Variations in hip shape are associated with radiographic knee osteoarthritis: Cross-sectional and longitudinal analyses of the johnston county osteoarthritis project",
abstract = "Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints. Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95\{%} of shape variance). Outcomes included prevalent [baseline KL ? 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ? 2), and progressive knee rOA (KL increase of ? 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations. Results.We evaluated 681 hips and 682 knees from 342 individuals (61\{%} women, 83\{%} white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15\{%}) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA. Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA. The Journal of Rheumatology.",
keywords = "Hip joint, Knee osteoarthritis, Radiography",
author = "Nelson, {Amanda E.} and Golightly, {Yvonne M.} and Renner, {Jordan B.} and Schwartz, {Todd A.} and Felix Liu and Lynch, {John A.} and Gregory, {Jenny S.} and Aspden, {Richard M.} and Lane, {Nancy E.} and Jordan, {Joanne M.}",
year = "2016",
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TY - JOUR

T1 - Variations in hip shape are associated with radiographic knee osteoarthritis

T2 - Journal of Rheumatology

AU - Nelson,Amanda E.

AU - Golightly,Yvonne M.

AU - Renner,Jordan B.

AU - Schwartz,Todd A.

AU - Liu,Felix

AU - Lynch,John A.

AU - Gregory,Jenny S.

AU - Aspden,Richard M.

AU - Lane,Nancy E.

AU - Jordan,Joanne M.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints. Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ? 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ? 2), and progressive knee rOA (KL increase of ? 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations. Results.We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA. Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA. The Journal of Rheumatology.

AB - Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints. Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ? 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ? 2), and progressive knee rOA (KL increase of ? 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations. Results.We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA. Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA. The Journal of Rheumatology.

KW - Hip joint

KW - Knee osteoarthritis

KW - Radiography

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