Tylophorine Analogs as Antitumor Agents

Kuo-Hsiung Lee (Inventor), Linyi Wei (Inventor), Kenneth F. Bastow (Inventor), Arnold Brossi (Inventor), Tian-Shung Wu (Inventor)

Research output: Patent

Abstract

Compounds of Formula I are described: preferably subject to the proviso that either (a) R.sup.2 and R.sup.3 together form --O--CH(R.sup.10)--O--, or (b) R.sup.5 and R.sup.6 together form --O--CH(R.sup.10)--O--, wherein R.sup.10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.
LanguageEnglish
Patent number8188089
IPCA61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101)
StatePublished - 1800

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Drug Compounding
Antineoplastic Agents
Salts
Neoplasms
tylophorine

Cite this

Lee, K-H., Wei, L., Bastow, K. F., Brossi, A., & Wu, T-S. (1800). IPC No. A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101). Tylophorine Analogs as Antitumor Agents (Patent No. 8188089.)

Tylophorine Analogs as Antitumor Agents. / Lee, Kuo-Hsiung (Inventor); Wei, Linyi (Inventor); Bastow, Kenneth F. (Inventor); Brossi, Arnold (Inventor); Wu, Tian-Shung (Inventor).

IPC No.: A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101). Patent No.: 8188089.

Research output: Patent

Lee, K-H, Wei, L, Bastow, KF, Brossi, A & Wu, T-S 1800, Tylophorine Analogs as Antitumor Agents, Patent No. 8188089, IPC No. A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101).
Lee K-H, Wei L, Bastow KF, Brossi A, Wu T-S, inventors. Tylophorine Analogs as Antitumor Agents. A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101). 1800
Lee, Kuo-Hsiung (Inventor) ; Wei, Linyi (Inventor) ; Bastow, Kenneth F. (Inventor) ; Brossi, Arnold (Inventor) ; Wu, Tian-Shung (Inventor). / Tylophorine Analogs as Antitumor Agents. IPC No.: A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101). Patent No.: 8188089.
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title = "Tylophorine Analogs as Antitumor Agents",
abstract = "Compounds of Formula I are described: preferably subject to the proviso that either (a) R.sup.2 and R.sup.3 together form --O--CH(R.sup.10)--O--, or (b) R.sup.5 and R.sup.6 together form --O--CH(R.sup.10)--O--, wherein R.sup.10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.",
author = "Kuo-Hsiung Lee and Linyi Wei and Bastow, {Kenneth F.} and Arnold Brossi and Tian-Shung Wu",
note = "Status: published applicationnumber: 12/096,950 usclass: 514/254.11 ; 514/321; 514/467; 544/378; 546/197; 548/526; 549/342 applicationnumber: 12/096,950; 8188089; A61K 31/496 (20060101); C07D 317/70 (20060101); A61K 31/36 (20060101); A61K 31/4525 (20060101); C07D 405/06 (20060101)",
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TY - PAT

T1 - Tylophorine Analogs as Antitumor Agents

AU - Lee,Kuo-Hsiung

AU - Wei,Linyi

AU - Bastow,Kenneth F.

AU - Brossi,Arnold

AU - Wu,Tian-Shung

N1 - Status: published applicationnumber: 12/096,950 usclass: 514/254.11 ; 514/321; 514/467; 544/378; 546/197; 548/526; 549/342 applicationnumber: 12/096,950

PY - 1800

Y1 - 1800

N2 - Compounds of Formula I are described: preferably subject to the proviso that either (a) R.sup.2 and R.sup.3 together form --O--CH(R.sup.10)--O--, or (b) R.sup.5 and R.sup.6 together form --O--CH(R.sup.10)--O--, wherein R.sup.10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.

AB - Compounds of Formula I are described: preferably subject to the proviso that either (a) R.sup.2 and R.sup.3 together form --O--CH(R.sup.10)--O--, or (b) R.sup.5 and R.sup.6 together form --O--CH(R.sup.10)--O--, wherein R.sup.10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.

M3 - Patent

M1 - 8188089

ER -