Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles

Richard R. Tidwell (Inventor), Svetlana M. Bakunova (Inventor), Stanislav Bakunov (Inventor), Donald A. Patrick (Inventor)

Research output: Patent

Abstract

Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
LanguageEnglish
Patent number7951827
IPCA61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101)
StatePublished - 1800

Fingerprint

Poisons
furamidine

Cite this

Tidwell, R. R., Bakunova, S. M., Bakunov, S., & Patrick, D. A. (1800). IPC No. A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101). Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles (Patent No. 7951827.)

Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles. / Tidwell, Richard R. (Inventor); Bakunova, Svetlana M. (Inventor); Bakunov, Stanislav (Inventor); Patrick, Donald A. (Inventor).

IPC No.: A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101). Patent No.: 7951827.

Research output: Patent

Tidwell, RR, Bakunova, SM, Bakunov, S & Patrick, DA 1800, Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles, Patent No. 7951827, IPC No. A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101).
Tidwell RR, Bakunova SM, Bakunov S, Patrick DA, inventors. Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles. A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101). 1800
Tidwell, Richard R. (Inventor) ; Bakunova, Svetlana M. (Inventor) ; Bakunov, Stanislav (Inventor) ; Patrick, Donald A. (Inventor). / Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles. IPC No.: A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101). Patent No.: 7951827.
@misc{80bf71630f014743aa87ff8d28cb6ba3,
title = "Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles",
abstract = "Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.",
author = "Tidwell, {Richard R.} and Bakunova, {Svetlana M.} and Stanislav Bakunov and Patrick, {Donald A.}",
note = "Status: published applicationnumber: 11/415,982 usclass: 514/378 ; 548/247 applicationnumber: 11/415,982; 7951827; A61K 31/42 (20060101); C07D 261/06 (20060101); C07D 413/02 (20060101)",
year = "1800",
language = "English",
type = "Patent",

}

TY - PAT

T1 - Synthesis and Antiprotozoal Activity of Dicationic 3.5 Diphenylisoxazoles

AU - Tidwell,Richard R.

AU - Bakunova,Svetlana M.

AU - Bakunov,Stanislav

AU - Patrick,Donald A.

N1 - Status: published applicationnumber: 11/415,982 usclass: 514/378 ; 548/247 applicationnumber: 11/415,982

PY - 1800

Y1 - 1800

N2 - Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

AB - Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

M3 - Patent

M1 - 7951827

ER -