Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines"

David W. Boykin (Inventor), Richard R. Tidwell (Inventor), W. David Wilson (Inventor), John R. Perfect (Inventor), Chad F. Stephens (Inventor)

Research output: ResearchPatent

Abstract

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R.sub.5 is H, alkyl or aryl; R.sub.6 is H, alkyl, aryl, or NR.sub.7R.sub.8, in which R.sub.7 and R.sub.8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR.sub.9, in which R.sub.9 is H or alkyl, and to the use of such compounds.
LanguageEnglish
Patent number7745456
IPCA61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101)
StatePublished - 1800

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Amidines
Furans
Thiophenes
Patents and inventions
alkoxyl radical

Keywords

    Cite this

    Boykin, D. W., Tidwell, R. R., Wilson, W. D., Perfect, J. R., & Stephens, C. F. (1800). IPC No. A61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101). Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines" (Patent No. 7745456.)

    Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines". / Boykin, David W. (Inventor); Tidwell, Richard R. (Inventor); Wilson, W. David (Inventor); Perfect, John R. (Inventor); Stephens, Chad F. (Inventor).

    IPC No.: A61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101). Patent No.: 7745456.

    Research output: ResearchPatent

    Boykin, DW, Tidwell, RR, Wilson, WD, Perfect, JR & Stephens, CF 1800, Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines", Patent No. 7745456, IPC No. A61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101).
    Boykin DW, Tidwell RR, Wilson WD, Perfect JR, Stephens CF, inventors. Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines". A61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101). 1800
    Boykin, David W. (Inventor) ; Tidwell, Richard R. (Inventor) ; Wilson, W. David (Inventor) ; Perfect, John R. (Inventor) ; Stephens, Chad F. (Inventor). / Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines". IPC No.: A61K 31/435 (20060101); A01N 43/08 (20060101); A61K 31/40 (20060101); A61K 31/38 (20060101); C07D 307/02 (20060101); C07D 307/34 (20060101); C07D 333/38 (20060101); C07D 295/04 (20060101); A61K 31/47 (20060101); C07D 405/12 (20060101). Patent No.: 7745456.
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    abstract = "The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R.sub.5 is H, alkyl or aryl; R.sub.6 is H, alkyl, aryl, or NR.sub.7R.sub.8, in which R.sub.7 and R.sub.8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR.sub.9, in which R.sub.9 is H or alkyl, and to the use of such compounds.",
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    author = "Boykin, {David W.} and Tidwell, {Richard R.} and Wilson, {W. David} and Perfect, {John R.} and Stephens, {Chad F.}",
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    TY - PAT

    T1 - Synthesis and Antimicrobial Activity of Novel Dicationic "Reversed Amidines"

    AU - Boykin,David W.

    AU - Tidwell,Richard R.

    AU - Wilson,W. David

    AU - Perfect,John R.

    AU - Stephens,Chad F.

    N1 - Status: published applicationnumber: 11/825,786 usclass: 514/277 ; 514/314; 514/408; 514/438; 514/471; 514/491; 548/577; 549/472; 549/491; 549/71 applicationnumber: 11/825,786

    PY - 1800

    Y1 - 1800

    N2 - The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R.sub.5 is H, alkyl or aryl; R.sub.6 is H, alkyl, aryl, or NR.sub.7R.sub.8, in which R.sub.7 and R.sub.8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR.sub.9, in which R.sub.9 is H or alkyl, and to the use of such compounds.

    AB - The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R.sub.5 is H, alkyl or aryl; R.sub.6 is H, alkyl, aryl, or NR.sub.7R.sub.8, in which R.sub.7 and R.sub.8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR.sub.9, in which R.sub.9 is H or alkyl, and to the use of such compounds.

    KW - 514/491,472,314,408,438,471,277,311 548/577 549/491,472,71 546/256

    M3 - Patent

    M1 - 7745456

    ER -