(Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA

P. S. Henthorn, O. Smithies, T. Nakatsuji, A. E. Felice, M. B. Gardiner, A. L. Reese, T. H J Huisman

Research output: Research - peer-reviewArticle

  • 21 Citations

Abstract

DNA from members of 10 Black families with conditions considered to be Gγδβ)°‐thalassaemia or Gγδβ)°‐HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β‐globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the Aγ and all of the Ψβ, δ and β‐globin genes and is different from the four previously identified deletions which caused a condition presently known as (Aγδβ)°‐thalassaemia.

LanguageEnglish (US)
Pages343-356
Number of pages14
JournalBritish Journal of Haematology
Volume59
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Thalassemia
DNA
beta-Globins
delta-Globins
Restriction Mapping
Multigene Family
Clone Cells
Genes

ASJC Scopus subject areas

  • Hematology

Cite this

Henthorn, P. S., Smithies, O., Nakatsuji, T., Felice, A. E., Gardiner, M. B., Reese, A. L., & Huisman, T. H. J. (1985). (Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. British Journal of Haematology, 59(2), 343-356. DOI: 10.1111/j.1365-2141.1985.tb02999.x

(Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. / Henthorn, P. S.; Smithies, O.; Nakatsuji, T.; Felice, A. E.; Gardiner, M. B.; Reese, A. L.; Huisman, T. H J.

In: British Journal of Haematology, Vol. 59, No. 2, 1985, p. 343-356.

Research output: Research - peer-reviewArticle

Henthorn, PS, Smithies, O, Nakatsuji, T, Felice, AE, Gardiner, MB, Reese, AL & Huisman, THJ 1985, '(Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA' British Journal of Haematology, vol 59, no. 2, pp. 343-356. DOI: 10.1111/j.1365-2141.1985.tb02999.x
Henthorn PS, Smithies O, Nakatsuji T, Felice AE, Gardiner MB, Reese AL et al. (Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. British Journal of Haematology. 1985;59(2):343-356. Available from, DOI: 10.1111/j.1365-2141.1985.tb02999.x
Henthorn, P. S. ; Smithies, O. ; Nakatsuji, T. ; Felice, A. E. ; Gardiner, M. B. ; Reese, A. L. ; Huisman, T. H J. / (Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. In: British Journal of Haematology. 1985 ; Vol. 59, No. 2. pp. 343-356
@article{879fba42254c468293c71deeee5859c2,
title = "(Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA",
abstract = "DNA from members of 10 Black families with conditions considered to be Gγδβ)°‐thalassaemia or Gγδβ)°‐HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β‐globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the Aγ and all of the Ψβ, δ and β‐globin genes and is different from the four previously identified deletions which caused a condition presently known as (Aγδβ)°‐thalassaemia.",
author = "Henthorn, {P. S.} and O. Smithies and T. Nakatsuji and Felice, {A. E.} and Gardiner, {M. B.} and Reese, {A. L.} and Huisman, {T. H J}",
year = "1985",
doi = "10.1111/j.1365-2141.1985.tb02999.x",
volume = "59",
pages = "343--356",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - (Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA

AU - Henthorn,P. S.

AU - Smithies,O.

AU - Nakatsuji,T.

AU - Felice,A. E.

AU - Gardiner,M. B.

AU - Reese,A. L.

AU - Huisman,T. H J

PY - 1985

Y1 - 1985

N2 - DNA from members of 10 Black families with conditions considered to be Gγδβ)°‐thalassaemia or Gγδβ)°‐HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β‐globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the Aγ and all of the Ψβ, δ and β‐globin genes and is different from the four previously identified deletions which caused a condition presently known as (Aγδβ)°‐thalassaemia.

AB - DNA from members of 10 Black families with conditions considered to be Gγδβ)°‐thalassaemia or Gγδβ)°‐HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β‐globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the Aγ and all of the Ψβ, δ and β‐globin genes and is different from the four previously identified deletions which caused a condition presently known as (Aγδβ)°‐thalassaemia.

UR - http://www.scopus.com/inward/record.url?scp=0021963031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021963031&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.1985.tb02999.x

DO - 10.1111/j.1365-2141.1985.tb02999.x

M3 - Article

VL - 59

SP - 343

EP - 356

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -