[18F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging

Kantapat Chansaenpak, Mengzhe Wang, Zhanhong Wu, Rehmat Zaman, Zibo Li, François P. Gabbaï

Research output: Contribution to journalArticle

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Abstract

The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [18F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an 18F-19F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.

LanguageEnglish (US)
Pages12439-12442
Number of pages4
JournalChemical Communications
Volume51
Issue number62
DOIs
StatePublished - Aug 11 2015

Fingerprint

Positron emission tomography
Prosthetics
Labeling
Peptides
Boron
Imaging techniques
Lewis Acids
Acids
Water
Fluorides
carbene
stannic chloride
maleimide
boron trifluoride

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

[18F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging. / Chansaenpak, Kantapat; Wang, Mengzhe; Wu, Zhanhong; Zaman, Rehmat; Li, Zibo; Gabbaï, François P.

In: Chemical Communications, Vol. 51, No. 62, 11.08.2015, p. 12439-12442.

Research output: Contribution to journalArticle

Chansaenpak, Kantapat ; Wang, Mengzhe ; Wu, Zhanhong ; Zaman, Rehmat ; Li, Zibo ; Gabbaï, François P. / [18F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging. In: Chemical Communications. 2015 ; Vol. 51, No. 62. pp. 12439-12442.
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