Relationship between ozone exposure and pulmonary function changes

Research output: Contribution to journalReview article

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Abstract

A detailed comparison of literature-reported averaged decrements in pulmonary function of normal subjects exposed to O3 has been undertaken. The data base was formed by including data published during the past 20 yr from studies that reported at least one of the pulmonary function variables (forced vital capacity, forced expiratory volume at 1 s, mean forced expiratory flow between 25 and 75% of forced vital capacity, and airway resistance) acquired at 2 h of exposures utilizing either original or modified Bates-Hazucha (intermittent exercise) protocol and that satisfied selection criteria. The final set of data (24 studies involving 299 subjects) was divided by ventilation rate (exercise loads) into four categories: light, moderate, high, and very high ventilation level. For each pulmonary function variable and ventilation level a quadratic function has been fitted to the data using regression procedures. The curve parameter estimates have been computed, tabulated, and statistically evaluated. The slope (quadratic coefficient) for each variable within a group and almost all variables between groups were significantly different from zero and from each other at P ≤ 0.0001.

LanguageEnglish (US)
Pages1671-1680
Number of pages10
JournalJournal of Applied Physiology
Volume62
Issue number4
StatePublished - 1987

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Ozone
Ventilation
Vital Capacity
Lung
Airway Resistance
Forced Expiratory Volume
Patient Selection
Databases
Light

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Relationship between ozone exposure and pulmonary function changes. / Hazucha, M. J.

In: Journal of Applied Physiology, Vol. 62, No. 4, 1987, p. 1671-1680.

Research output: Contribution to journalReview article

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