Prospective evaluation of luteal phase length and natural fertility

Natalie M. Crawford, David A. Pritchard, Amy H. Herring, Anne Z. Steiner

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

Objective To evaluate the impact of a short luteal phase on fecundity. Design Prospective time-to-pregnancy cohort study. Setting Not applicable. Patient(s) Women trying to conceive, ages 30–44 years, without known infertility. Intervention(s) Daily diaries, ovulation prediction testing, standardized pregnancy testing. Main Outcome Measure(s) Subsequent cycle fecundity. Result(s) Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (≤11 days including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy. Conclusion(s) Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women. Clinical Trial Registration Number NCT01028365.

LanguageEnglish (US)
Pages749-755
Number of pages7
JournalFertility and Sterility
Volume107
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Luteal Phase
Fertility
Pregnancy
Infertility
Ovulation Prediction
Time-to-Pregnancy
Corpus Luteum
Ovulation
Cohort Studies
Outcome Assessment (Health Care)
Clinical Trials
Incidence

Keywords

  • fecundity
  • luteal phase deficiency
  • natural fertility
  • Short luteal phase

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Prospective evaluation of luteal phase length and natural fertility. / Crawford, Natalie M.; Pritchard, David A.; Herring, Amy H.; Steiner, Anne Z.

In: Fertility and Sterility, Vol. 107, No. 3, 01.03.2017, p. 749-755.

Research output: Contribution to journalArticle

Crawford, Natalie M. ; Pritchard, David A. ; Herring, Amy H. ; Steiner, Anne Z./ Prospective evaluation of luteal phase length and natural fertility. In: Fertility and Sterility. 2017 ; Vol. 107, No. 3. pp. 749-755
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