Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Redford B. Williams, George D. Bishop, Brett C. Haberstick, Andrew Smolen, Beverly H. Brummett, Ilene C. Siegler, Michael A. Babyak, Xiaodong Zhang, E. Shyong Tai, Jeannette Jen Mai Lee, Maudrene Tan, Yik Ying Teo, Shiwei Cai, Edmund Chan, Carolyn Tucker Halpern, Eric A. Whitsel, Shawn Bauldry, Kathleen Mullan Harris

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Abstract

Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L′S′, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In US Whites, L′ allele carriers had higher SBP (0.9 mm Hg, 95% CI = 0.26-1.56) and greater odds (OR = 1.23, 95% CI = 1.10-1.38) of more severe hypertension than those with S′S′ genotypes. In African Americans, L′ carriers had lower mean SBP (−1.27 mm Hg, 95% CI = −2.53 to −0.01) and lower odds (OR = 0.78, 95% CI = 0.65-0.94) of more severe hypertension than those with the S′S′ genotype. In African Americans, those with L′L′ genotypes had lower DBP (−1.13 mm Hg, 95% CI = −2.09 to −0.16) than S′ carriers. In Native Americans, L′ carriers had lower SBP (−6.05 mm Hg, 95% CI = −9.59 to −2.51) and lower odds of hypertension (OR = 0.34, 95% CI = 0.13-0.89) than those with the S′S′ genotype. In Asian/Pacific Islanders those carrying the L′ allele had lower DBP (−1.77 mm Hg, 95% CI = −3.16 to −0.38) and lower odds of hypertension (OR = 0.68, 95% CI = 0.48-0.96) than those with S′S′. In the Singapore sample S′ carriers had higher SBP (3.02 mm Hg, 95% CI = 0.54-5.51) and DBP (1.90 mm Hg, 95% CI = 0.49-3.31) than those with the L′L′ genotype. Conclusions These findings suggest that Whites carrying the L′ allele, African Americans and Native Americans with the S′S′ genotype, and Asians carrying the S′ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.

LanguageEnglish (US)
Pages110-122
Number of pages13
JournalAmerican Heart Journal
Volume185
DOIs
StatePublished - Mar 1 2017

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Serotonin Plasma Membrane Transport Proteins
Genotype
Blood Pressure
Hypertension
Alleles
Population
African Americans
North American Indians
Singapore
Logistic Models
Health
Longitudinal Studies
Linear Models
Cardiovascular Diseases
Myocardial Infarction
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence. / Williams, Redford B.; Bishop, George D.; Haberstick, Brett C.; Smolen, Andrew; Brummett, Beverly H.; Siegler, Ilene C.; Babyak, Michael A.; Zhang, Xiaodong; Tai, E. Shyong; Lee, Jeannette Jen Mai; Tan, Maudrene; Teo, Yik Ying; Cai, Shiwei; Chan, Edmund; Halpern, Carolyn Tucker; Whitsel, Eric A.; Bauldry, Shawn; Harris, Kathleen Mullan.

In: American Heart Journal, Vol. 185, 01.03.2017, p. 110-122.

Research output: Contribution to journalArticle

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JJM, Tan, M, Teo, YY, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Bauldry, S & Harris, KM 2017, 'Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence' American Heart Journal, vol. 185, pp. 110-122. DOI: 10.1016/j.ahj.2016.12.013
Williams, Redford B. ; Bishop, George D. ; Haberstick, Brett C. ; Smolen, Andrew ; Brummett, Beverly H. ; Siegler, Ilene C. ; Babyak, Michael A. ; Zhang, Xiaodong ; Tai, E. Shyong ; Lee, Jeannette Jen Mai ; Tan, Maudrene ; Teo, Yik Ying ; Cai, Shiwei ; Chan, Edmund ; Halpern, Carolyn Tucker ; Whitsel, Eric A. ; Bauldry, Shawn ; Harris, Kathleen Mullan. / Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence. In: American Heart Journal. 2017 ; Vol. 185. pp. 110-122
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abstract = "Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L′S′, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In US Whites, L′ allele carriers had higher SBP (0.9 mm Hg, 95{\%} CI = 0.26-1.56) and greater odds (OR = 1.23, 95{\%} CI = 1.10-1.38) of more severe hypertension than those with S′S′ genotypes. In African Americans, L′ carriers had lower mean SBP (−1.27 mm Hg, 95{\%} CI = −2.53 to −0.01) and lower odds (OR = 0.78, 95{\%} CI = 0.65-0.94) of more severe hypertension than those with the S′S′ genotype. In African Americans, those with L′L′ genotypes had lower DBP (−1.13 mm Hg, 95{\%} CI = −2.09 to −0.16) than S′ carriers. In Native Americans, L′ carriers had lower SBP (−6.05 mm Hg, 95{\%} CI = −9.59 to −2.51) and lower odds of hypertension (OR = 0.34, 95{\%} CI = 0.13-0.89) than those with the S′S′ genotype. In Asian/Pacific Islanders those carrying the L′ allele had lower DBP (−1.77 mm Hg, 95{\%} CI = −3.16 to −0.38) and lower odds of hypertension (OR = 0.68, 95{\%} CI = 0.48-0.96) than those with S′S′. In the Singapore sample S′ carriers had higher SBP (3.02 mm Hg, 95{\%} CI = 0.54-5.51) and DBP (1.90 mm Hg, 95{\%} CI = 0.49-3.31) than those with the L′L′ genotype. Conclusions These findings suggest that Whites carrying the L′ allele, African Americans and Native Americans with the S′S′ genotype, and Asians carrying the S′ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.",
author = "Williams, {Redford B.} and Bishop, {George D.} and Haberstick, {Brett C.} and Andrew Smolen and Brummett, {Beverly H.} and Siegler, {Ilene C.} and Babyak, {Michael A.} and Xiaodong Zhang and Tai, {E. Shyong} and Lee, {Jeannette Jen Mai} and Maudrene Tan and Teo, {Yik Ying} and Shiwei Cai and Edmund Chan and Halpern, {Carolyn Tucker} and Whitsel, {Eric A.} and Shawn Bauldry and Harris, {Kathleen Mullan}",
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T1 - Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

AU - Williams,Redford B.

AU - Bishop,George D.

AU - Haberstick,Brett C.

AU - Smolen,Andrew

AU - Brummett,Beverly H.

AU - Siegler,Ilene C.

AU - Babyak,Michael A.

AU - Zhang,Xiaodong

AU - Tai,E. Shyong

AU - Lee,Jeannette Jen Mai

AU - Tan,Maudrene

AU - Teo,Yik Ying

AU - Cai,Shiwei

AU - Chan,Edmund

AU - Halpern,Carolyn Tucker

AU - Whitsel,Eric A.

AU - Bauldry,Shawn

AU - Harris,Kathleen Mullan

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L′S′, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In US Whites, L′ allele carriers had higher SBP (0.9 mm Hg, 95% CI = 0.26-1.56) and greater odds (OR = 1.23, 95% CI = 1.10-1.38) of more severe hypertension than those with S′S′ genotypes. In African Americans, L′ carriers had lower mean SBP (−1.27 mm Hg, 95% CI = −2.53 to −0.01) and lower odds (OR = 0.78, 95% CI = 0.65-0.94) of more severe hypertension than those with the S′S′ genotype. In African Americans, those with L′L′ genotypes had lower DBP (−1.13 mm Hg, 95% CI = −2.09 to −0.16) than S′ carriers. In Native Americans, L′ carriers had lower SBP (−6.05 mm Hg, 95% CI = −9.59 to −2.51) and lower odds of hypertension (OR = 0.34, 95% CI = 0.13-0.89) than those with the S′S′ genotype. In Asian/Pacific Islanders those carrying the L′ allele had lower DBP (−1.77 mm Hg, 95% CI = −3.16 to −0.38) and lower odds of hypertension (OR = 0.68, 95% CI = 0.48-0.96) than those with S′S′. In the Singapore sample S′ carriers had higher SBP (3.02 mm Hg, 95% CI = 0.54-5.51) and DBP (1.90 mm Hg, 95% CI = 0.49-3.31) than those with the L′L′ genotype. Conclusions These findings suggest that Whites carrying the L′ allele, African Americans and Native Americans with the S′S′ genotype, and Asians carrying the S′ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.

AB - Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L′S′, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In US Whites, L′ allele carriers had higher SBP (0.9 mm Hg, 95% CI = 0.26-1.56) and greater odds (OR = 1.23, 95% CI = 1.10-1.38) of more severe hypertension than those with S′S′ genotypes. In African Americans, L′ carriers had lower mean SBP (−1.27 mm Hg, 95% CI = −2.53 to −0.01) and lower odds (OR = 0.78, 95% CI = 0.65-0.94) of more severe hypertension than those with the S′S′ genotype. In African Americans, those with L′L′ genotypes had lower DBP (−1.13 mm Hg, 95% CI = −2.09 to −0.16) than S′ carriers. In Native Americans, L′ carriers had lower SBP (−6.05 mm Hg, 95% CI = −9.59 to −2.51) and lower odds of hypertension (OR = 0.34, 95% CI = 0.13-0.89) than those with the S′S′ genotype. In Asian/Pacific Islanders those carrying the L′ allele had lower DBP (−1.77 mm Hg, 95% CI = −3.16 to −0.38) and lower odds of hypertension (OR = 0.68, 95% CI = 0.48-0.96) than those with S′S′. In the Singapore sample S′ carriers had higher SBP (3.02 mm Hg, 95% CI = 0.54-5.51) and DBP (1.90 mm Hg, 95% CI = 0.49-3.31) than those with the L′L′ genotype. Conclusions These findings suggest that Whites carrying the L′ allele, African Americans and Native Americans with the S′S′ genotype, and Asians carrying the S′ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.

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