Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer

Yasuhiko Kubota, Kelly R. Evenson, Richard F. MacLehose, Nicholas S. Roetker, Corinne E. Joshu, Aaron R. Folsom

Research output: Research - peer-reviewArticle

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Abstract

PURPOSE: Although the World Health Organization (WHO) has recommended moderate- to vigorous-intensity physical activity (MVPA) to prevent cardiovascular disease (CVD) and some cancers, there are no estimates of lifetime risk of these non-communicable diseases according to PA levels. We aimed to estimate the lifetime risk of CVD and cancers according to PA levels. METHODS: We followed 5,807 men and 7,252 women in the U.S. age 45–64 initially free of CVD and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of CVD (coronary heart disease, heart failure and stroke) and total cancer according to PA levels: poor (0 minutes/week of MVPA), intermediate (1–74 minutes/week of VPA or 1–149 minutes/week of MVPA) or recommended (≥75 minutes/week of VPA or ≥150 minutes/week of MVPA). RESULTS: During the 246,886 person-years of follow-up, we documented 4,065 CVD and 3,509 cancer events, and 2,062 non-CVD and 2,326 non-cancer deaths. In men, the lifetime risks of CVD from 45 through 85 years were 52.7% (95% confidence interval, 49.4–55.5) for poor PA and 45.7% (42.7–48.3) for recommended PA. In women, the respective lifetime risks of CVD were 42.4% (39.5–44.9) and 30.5% (27.5–33.1). Lifetime risks of total cancer in men were 40.1% (36.9–42.7) for poor PA and 42.6% (39.7–45.2) for recommended activity; in women, 31.4% (28.7–33.8) and 30.4% (27.7–32.9), respectively. CONCLUSIONS: Compared with a poor PA level, WHO recommended PA was associated with lower lifetime risk of CVD, but not total cancer, in both men and women.

LanguageEnglish (US)
JournalMedicine and Science in Sports and Exercise
DOIs
StateAccepted/In press - Mar 27 2017

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Cardiovascular Diseases
Exercise
Neoplasms
Life Tables
Health Status
Coronary Disease
Heart Failure
Stroke
Confidence Intervals

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer. / Kubota, Yasuhiko; Evenson, Kelly R.; MacLehose, Richard F.; Roetker, Nicholas S.; Joshu, Corinne E.; Folsom, Aaron R.

In: Medicine and Science in Sports and Exercise, 27.03.2017.

Research output: Research - peer-reviewArticle

Kubota, Yasuhiko ; Evenson, Kelly R. ; MacLehose, Richard F. ; Roetker, Nicholas S. ; Joshu, Corinne E. ; Folsom, Aaron R./ Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer. In: Medicine and Science in Sports and Exercise. 2017
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abstract = "PURPOSE: Although the World Health Organization (WHO) has recommended moderate- to vigorous-intensity physical activity (MVPA) to prevent cardiovascular disease (CVD) and some cancers, there are no estimates of lifetime risk of these non-communicable diseases according to PA levels. We aimed to estimate the lifetime risk of CVD and cancers according to PA levels. METHODS: We followed 5,807 men and 7,252 women in the U.S. age 45–64 initially free of CVD and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of CVD (coronary heart disease, heart failure and stroke) and total cancer according to PA levels: poor (0 minutes/week of MVPA), intermediate (1–74 minutes/week of VPA or 1–149 minutes/week of MVPA) or recommended (≥75 minutes/week of VPA or ≥150 minutes/week of MVPA). RESULTS: During the 246,886 person-years of follow-up, we documented 4,065 CVD and 3,509 cancer events, and 2,062 non-CVD and 2,326 non-cancer deaths. In men, the lifetime risks of CVD from 45 through 85 years were 52.7% (95% confidence interval, 49.4–55.5) for poor PA and 45.7% (42.7–48.3) for recommended PA. In women, the respective lifetime risks of CVD were 42.4% (39.5–44.9) and 30.5% (27.5–33.1). Lifetime risks of total cancer in men were 40.1% (36.9–42.7) for poor PA and 42.6% (39.7–45.2) for recommended activity; in women, 31.4% (28.7–33.8) and 30.4% (27.7–32.9), respectively. CONCLUSIONS: Compared with a poor PA level, WHO recommended PA was associated with lower lifetime risk of CVD, but not total cancer, in both men and women.",
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N2 - PURPOSE: Although the World Health Organization (WHO) has recommended moderate- to vigorous-intensity physical activity (MVPA) to prevent cardiovascular disease (CVD) and some cancers, there are no estimates of lifetime risk of these non-communicable diseases according to PA levels. We aimed to estimate the lifetime risk of CVD and cancers according to PA levels. METHODS: We followed 5,807 men and 7,252 women in the U.S. age 45–64 initially free of CVD and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of CVD (coronary heart disease, heart failure and stroke) and total cancer according to PA levels: poor (0 minutes/week of MVPA), intermediate (1–74 minutes/week of VPA or 1–149 minutes/week of MVPA) or recommended (≥75 minutes/week of VPA or ≥150 minutes/week of MVPA). RESULTS: During the 246,886 person-years of follow-up, we documented 4,065 CVD and 3,509 cancer events, and 2,062 non-CVD and 2,326 non-cancer deaths. In men, the lifetime risks of CVD from 45 through 85 years were 52.7% (95% confidence interval, 49.4–55.5) for poor PA and 45.7% (42.7–48.3) for recommended PA. In women, the respective lifetime risks of CVD were 42.4% (39.5–44.9) and 30.5% (27.5–33.1). Lifetime risks of total cancer in men were 40.1% (36.9–42.7) for poor PA and 42.6% (39.7–45.2) for recommended activity; in women, 31.4% (28.7–33.8) and 30.4% (27.7–32.9), respectively. CONCLUSIONS: Compared with a poor PA level, WHO recommended PA was associated with lower lifetime risk of CVD, but not total cancer, in both men and women.

AB - PURPOSE: Although the World Health Organization (WHO) has recommended moderate- to vigorous-intensity physical activity (MVPA) to prevent cardiovascular disease (CVD) and some cancers, there are no estimates of lifetime risk of these non-communicable diseases according to PA levels. We aimed to estimate the lifetime risk of CVD and cancers according to PA levels. METHODS: We followed 5,807 men and 7,252 women in the U.S. age 45–64 initially free of CVD and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of CVD (coronary heart disease, heart failure and stroke) and total cancer according to PA levels: poor (0 minutes/week of MVPA), intermediate (1–74 minutes/week of VPA or 1–149 minutes/week of MVPA) or recommended (≥75 minutes/week of VPA or ≥150 minutes/week of MVPA). RESULTS: During the 246,886 person-years of follow-up, we documented 4,065 CVD and 3,509 cancer events, and 2,062 non-CVD and 2,326 non-cancer deaths. In men, the lifetime risks of CVD from 45 through 85 years were 52.7% (95% confidence interval, 49.4–55.5) for poor PA and 45.7% (42.7–48.3) for recommended PA. In women, the respective lifetime risks of CVD were 42.4% (39.5–44.9) and 30.5% (27.5–33.1). Lifetime risks of total cancer in men were 40.1% (36.9–42.7) for poor PA and 42.6% (39.7–45.2) for recommended activity; in women, 31.4% (28.7–33.8) and 30.4% (27.7–32.9), respectively. CONCLUSIONS: Compared with a poor PA level, WHO recommended PA was associated with lower lifetime risk of CVD, but not total cancer, in both men and women.

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