Novel Curcumin Analogues and Uses Thereof

Kuo-Hsiung Lee (Inventor), Li Lin (Inventor), Charles C-Y Shih (Inventor), Ching-Yuan Su (Inventor), Junko Ishida (Inventor), Hironori Ohtsu (Inventor), Hui-Kang Wang (Inventor), Hideji Itokawa (Inventor), Chawnshang Chang (Inventor)

Research output: ResearchPatent

Abstract

The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
LanguageEnglish
Patent number8198323
IPCA61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101)
StatePublished - 1800

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Androgen Receptor Antagonists
Curcumin
Spermatogenesis
Androgens
Hirsutism
Drug Compounding
Alopecia
Acne Vulgaris
Skin Neoplasms
Antineoplastic Agents
Colonic Neoplasms
Prostatic Neoplasms
Neoplasms

Cite this

Lee, K-H., Lin, L., Shih, C. C-Y., Su, C-Y., Ishida, J., Ohtsu, H., ... Chang, C. (1800). IPC No. A61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101). Novel Curcumin Analogues and Uses Thereof (Patent No. 8198323.)

Novel Curcumin Analogues and Uses Thereof. / Lee, Kuo-Hsiung (Inventor); Lin, Li (Inventor); Shih, Charles C-Y (Inventor); Su, Ching-Yuan (Inventor); Ishida, Junko (Inventor); Ohtsu, Hironori (Inventor); Wang, Hui-Kang (Inventor); Itokawa, Hideji (Inventor); Chang, Chawnshang (Inventor).

IPC No.: A61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101). Patent No.: 8198323.

Research output: ResearchPatent

Lee, K-H, Lin, L, Shih, CC-Y, Su, C-Y, Ishida, J, Ohtsu, H, Wang, H-K, Itokawa, H & Chang, C 1800, Novel Curcumin Analogues and Uses Thereof, Patent No. 8198323, IPC No. A61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101).
Lee K-H, Lin L, Shih CC-Y, Su C-Y, Ishida J, Ohtsu H et al, inventors. Novel Curcumin Analogues and Uses Thereof. A61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101). 1800
Lee, Kuo-Hsiung (Inventor) ; Lin, Li (Inventor) ; Shih, Charles C-Y (Inventor) ; Su, Ching-Yuan (Inventor) ; Ishida, Junko (Inventor) ; Ohtsu, Hironori (Inventor) ; Wang, Hui-Kang (Inventor) ; Itokawa, Hideji (Inventor) ; Chang, Chawnshang (Inventor). / Novel Curcumin Analogues and Uses Thereof. IPC No.: A61K 31/235 (20060101); C12N 5/00 (20060101); C07C 49/10 (20060101). Patent No.: 8198323.
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abstract = "The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.",
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AU - Lee,Kuo-Hsiung

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N2 - The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

AB - The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

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