Mycobacterial SecA2 Mutants

[No Value] Jacobs (Inventor), William R. Jr. (Inventor), Steven A. Porcelli (Inventor), Miriam Braunstein (Inventor)

Research output: Patent

Abstract

Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
LanguageEnglish
Patent number8101191
IPCA61K 39/04 (20060101)
StatePublished - 1800

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Mycobacterium
Mutation
Genes
Mycobacterium smegmatis
Mycobacterium tuberculosis
Virulence
Mammals

Cite this

Jacobs, . N. V., Jr., W. R., Porcelli, S. A., & Braunstein, M. (1800). IPC No. A61K 39/04 (20060101). Mycobacterial SecA2 Mutants (Patent No. 8101191.)

Mycobacterial SecA2 Mutants. / Jacobs, [No Value] (Inventor); Jr., William R. (Inventor); Porcelli, Steven A. (Inventor); Braunstein, Miriam (Inventor).

IPC No.: A61K 39/04 (20060101). Patent No.: 8101191.

Research output: Patent

Jacobs, NV, Jr., WR, Porcelli, SA & Braunstein, M 1800, Mycobacterial SecA2 Mutants, Patent No. 8101191, IPC No. A61K 39/04 (20060101).
Jacobs NV, Jr. WR, Porcelli SA, Braunstein M, inventors. Mycobacterial SecA2 Mutants. A61K 39/04 (20060101). 1800
Jacobs, [No Value] (Inventor) ; Jr., William R. (Inventor) ; Porcelli, Steven A. (Inventor) ; Braunstein, Miriam (Inventor). / Mycobacterial SecA2 Mutants. IPC No.: A61K 39/04 (20060101). Patent No.: 8101191.
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N2 - Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.

AB - Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.

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