Methods and Compositions Comprising Novel Cationic Lipids

Leaf Huang (Inventor), Yunching Chen (Inventor), Joyeeta Sen (Inventor), Surendar Reddy Bathula (Inventor), Sumio Chono (Inventor), Shyh-Dar Li (Inventor), Michael Hackett (Inventor)

Research output: ResearchPatent

Abstract

Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.
LanguageEnglish
Patent number8389768
IPCC07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101)
StatePublished - 1800

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Lipids

Keywords

    Cite this

    Huang, L., Chen, Y., Sen, J., Bathula, S. R., Chono, S., Li, S-D., & Hackett, M. (1800). IPC No. C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101). Methods and Compositions Comprising Novel Cationic Lipids (Patent No. 8389768.)

    Methods and Compositions Comprising Novel Cationic Lipids. / Huang, Leaf (Inventor); Chen, Yunching (Inventor); Sen, Joyeeta (Inventor); Bathula, Surendar Reddy (Inventor); Chono, Sumio (Inventor); Li, Shyh-Dar (Inventor); Hackett, Michael (Inventor).

    IPC No.: C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101). Patent No.: 8389768.

    Research output: ResearchPatent

    Huang, L, Chen, Y, Sen, J, Bathula, SR, Chono, S, Li, S-D & Hackett, M 1800, Methods and Compositions Comprising Novel Cationic Lipids, Patent No. 8389768, IPC No. C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101).
    Huang L, Chen Y, Sen J, Bathula SR, Chono S, Li S-D et al, inventors. Methods and Compositions Comprising Novel Cationic Lipids. C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101). 1800
    Huang, Leaf (Inventor) ; Chen, Yunching (Inventor) ; Sen, Joyeeta (Inventor) ; Bathula, Surendar Reddy (Inventor) ; Chono, Sumio (Inventor) ; Li, Shyh-Dar (Inventor) ; Hackett, Michael (Inventor). / Methods and Compositions Comprising Novel Cationic Lipids. IPC No.: C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101). Patent No.: 8389768.
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    title = "Methods and Compositions Comprising Novel Cationic Lipids",
    abstract = "Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.",
    keywords = "564/197,236,240 514/626,634",
    author = "Leaf Huang and Yunching Chen and Joyeeta Sen and Bathula, {Surendar Reddy} and Sumio Chono and Shyh-Dar Li and Michael Hackett",
    note = "Status: published applicationnumber: 12/993,421 usclass: 564/197 ; 424/400; 435/458; 564/176; 564/236; 564/240 applicationnumber: 12/993,421; 8389768; C07C 237/00 (20060101); C07C 279/00 (20060101); A61K 31/16 (20060101); A61K 31/155 (20060101)",
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    TY - PAT

    T1 - Methods and Compositions Comprising Novel Cationic Lipids

    AU - Huang,Leaf

    AU - Chen,Yunching

    AU - Sen,Joyeeta

    AU - Bathula,Surendar Reddy

    AU - Chono,Sumio

    AU - Li,Shyh-Dar

    AU - Hackett,Michael

    N1 - Status: published applicationnumber: 12/993,421 usclass: 564/197 ; 424/400; 435/458; 564/176; 564/236; 564/240 applicationnumber: 12/993,421

    PY - 1800

    Y1 - 1800

    N2 - Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.

    AB - Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.

    KW - 564/197,236,240 514/626,634

    M3 - Patent

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    ER -