Method for inhibiting Expression of a Protein in a Hepatocyte

Xianbin Tian (Inventor), Peijin Zhang (Inventor), Kim L. R. Brouwer (Inventor)

Research output: Patent

Abstract

A method of screening a candidate compound for susceptibility to biliary excretion by a hepatocyte transport protein. In some embodiments the method can comprise inhibiting expression of the transport protein. Expression of the transport protein can be inhibited through introduction of a RNA having a sequence corresponding to a coding strand of the gene encoding the transport protein into the hepatocyte.
LanguageEnglish
Patent number8367630
IPCA61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101)
StatePublished - 1800

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Hepatocytes
Carrier Proteins
Proteins
RNA
Genes

Keywords

    Cite this

    Tian, X., Zhang, P., & Brouwer, K. L. R. (1800). IPC No. A61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101). Method for inhibiting Expression of a Protein in a Hepatocyte (Patent No. 8367630.)

    Method for inhibiting Expression of a Protein in a Hepatocyte. / Tian, Xianbin (Inventor); Zhang, Peijin (Inventor); Brouwer, Kim L. R. (Inventor).

    IPC No.: A61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101). Patent No.: 8367630.

    Research output: Patent

    Tian, X, Zhang, P & Brouwer, KLR 1800, Method for inhibiting Expression of a Protein in a Hepatocyte, Patent No. 8367630, IPC No. A61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101).
    Tian X, Zhang P, Brouwer KLR, inventors. Method for inhibiting Expression of a Protein in a Hepatocyte. A61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101). 1800
    Tian, Xianbin (Inventor) ; Zhang, Peijin (Inventor) ; Brouwer, Kim L. R. (Inventor). / Method for inhibiting Expression of a Protein in a Hepatocyte. IPC No.: A61K 31/70 (20060101); C07H 21/04 (20060101); C07H 21/02 (20060101); C12P 19/34 (20060101); C12Q 1/68 (20060101). Patent No.: 8367630.
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    AU - Zhang,Peijin

    AU - Brouwer,Kim L. R.

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