Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents

Richard R. Tidwell (Inventor), David W. Boykin (Inventor), W. David Wilson (Inventor), Reto Brun (Inventor), Laixing Hu (Inventor), Karl Werbovetz (Inventor), Mohamed A. Ismail (Inventor), Reem K. Arafa (Inventor)

Research output: Patent

Abstract

Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): ##STR00001## wherein p and q are each 0 and each A, Y and Z is CR.sub.4. An exemplary compound of Formula (IIe) is: ##STR00002## Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.
LanguageEnglish
Patent number7964619
IPC1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D
StatePublished - 1800

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Terphenyl Compounds
Antiparasitic Agents
Aza Compounds

Keywords

    Cite this

    Tidwell, R. R., Boykin, D. W., Wilson, W. D., Brun, R., Hu, L., Werbovetz, K., ... Arafa, R. K. (1800). IPC No. 1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D. Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents (Patent No. 7964619.)

    Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents. / Tidwell, Richard R. (Inventor); Boykin, David W. (Inventor); Wilson, W. David (Inventor); Brun, Reto (Inventor); Hu, Laixing (Inventor); Werbovetz, Karl (Inventor); Ismail, Mohamed A. (Inventor); Arafa, Reem K. (Inventor).

    IPC No.: 1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D. Patent No.: 7964619.

    Research output: Patent

    Tidwell, RR, Boykin, DW, Wilson, WD, Brun, R, Hu, L, Werbovetz, K, Ismail, MA & Arafa, RK 1800, Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents, Patent No. 7964619, IPC No. 1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D.
    Tidwell RR, Boykin DW, Wilson WD, Brun R, Hu L, Werbovetz K et al, inventors. Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents. 1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D. 1800
    Tidwell, Richard R. (Inventor) ; Boykin, David W. (Inventor) ; Wilson, W. David (Inventor) ; Brun, Reto (Inventor) ; Hu, Laixing (Inventor) ; Werbovetz, Karl (Inventor) ; Ismail, Mohamed A. (Inventor) ; Arafa, Reem K. (Inventor). / Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents. IPC No.: 1C07C 257/18 (20130101); C07C 259/18 (20130101); C07C 279/18 (20130101); C07C 279/24 (20130101); C07D 213/58 (20130101); C07D. Patent No.: 7964619.
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    title = "Linear Dicationic Terphenyls and Their AZA Analogues as Antiparasitic Agents",
    abstract = "Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): ##STR00001## wherein p and q are each 0 and each A, Y and Z is CR.sub.4. An exemplary compound of Formula (IIe) is: ##STR00002## Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.",
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    AU - Tidwell,Richard R.

    AU - Boykin,David W.

    AU - Wilson,W. David

    AU - Brun,Reto

    AU - Hu,Laixing

    AU - Werbovetz,Karl

    AU - Ismail,Mohamed A.

    AU - Arafa,Reem K.

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    PY - 1800

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    N2 - Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): ##STR00001## wherein p and q are each 0 and each A, Y and Z is CR.sub.4. An exemplary compound of Formula (IIe) is: ##STR00002## Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

    AB - Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): ##STR00001## wherein p and q are each 0 and each A, Y and Z is CR.sub.4. An exemplary compound of Formula (IIe) is: ##STR00002## Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

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