(-)-Hydroxycitrate and conditioned aversions

Jaak Panksepp, Alan Pollack, Rick B. Meeker, Ann C. Sullivan

Research output: Contribution to journalArticle

  • 8 Citations

Abstract

The capacity of various salts of (-)-hydroxycitrate to produce conditioned rejection of a 0.25% saccharin solution was evaluated. The ethylenediamine salt of (-)-hydroxycitrate to produce produced strong conditioned rejection of saccharin under both deprivation and nondeprivation conditions, but this effect was less than produced by equimolar doses of lithium chloride. The sodium salt of hydroxycitrate produced no conditioned rejection of saccharin in water deprived rats but did so in nondeprived animals. In these experiments, food intake was reduced by (-)-hydroxycitrate only during the first hour following administration of the drug. The magnitude of appetite rejection did not correspond to the degree of conditioned rejection, lending support to the conclusion that the food intake reduction was not merely a consequence of aversive effects of the drug.

LanguageEnglish (US)
Pages683-687
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Saccharin
ethylenediamine
Salts
Lithium Chloride
Eating
Pharmaceutical Preparations
Rats
Appetite
Animals
Sodium
hydroxycitric acid
Rejection (Psychology)
Water
Experiments

Keywords

  • Appetite reduction
  • Conditioned aversions
  • Ethylenediamine
  • Food intake
  • Hydroxycitrate

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

(-)-Hydroxycitrate and conditioned aversions. / Panksepp, Jaak; Pollack, Alan; Meeker, Rick B.; Sullivan, Ann C.

In: Pharmacology, Biochemistry and Behavior, Vol. 6, No. 6, 01.01.1977, p. 683-687.

Research output: Contribution to journalArticle

Panksepp, J, Pollack, A, Meeker, RB & Sullivan, AC 1977, '(-)-Hydroxycitrate and conditioned aversions' Pharmacology, Biochemistry and Behavior, vol. 6, no. 6, pp. 683-687. DOI: 10.1016/0091-3057(77)90095-8
Panksepp J, Pollack A, Meeker RB, Sullivan AC. (-)-Hydroxycitrate and conditioned aversions. Pharmacology, Biochemistry and Behavior. 1977 Jan 1;6(6):683-687. Available from, DOI: 10.1016/0091-3057(77)90095-8
Panksepp, Jaak ; Pollack, Alan ; Meeker, Rick B. ; Sullivan, Ann C./ (-)-Hydroxycitrate and conditioned aversions. In: Pharmacology, Biochemistry and Behavior. 1977 ; Vol. 6, No. 6. pp. 683-687
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