Hepatic Stellate Cell Precursors and Methods of Isolating Same

Hiroshi Kubota (Inventor), Lola M. Reid (Inventor)

Research output: Patent

Abstract

The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1.sup.+, VCAM-1.sup.+, .beta.3-integrin.sup.+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle .alpha.-actin, nestin, hepatocyte growth factor, stromal derived factor-1.alpha. and H1x homeobox transcriptional factor.
LanguageEnglish
Patent number7824911
IPCC12N 5/00 (20060101)
StatePublished - 1800

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Hepatic Stellate Cells
Nestin
Desmin
Hepatocyte Growth Factor
Vascular Cell Adhesion Molecule-1
Homeobox Genes
Vimentin
Intercellular Adhesion Molecule-1
Integrins
Smooth Muscle
Actins

Cite this

Kubota, H., & Reid, L. M. (1800). IPC No. C12N 5/00 (20060101). Hepatic Stellate Cell Precursors and Methods of Isolating Same (Patent No. 7824911.)

Hepatic Stellate Cell Precursors and Methods of Isolating Same. / Kubota, Hiroshi (Inventor); Reid, Lola M. (Inventor).

IPC No.: C12N 5/00 (20060101). Patent No.: 7824911.

Research output: Patent

Kubota, H & Reid, LM 1800, Hepatic Stellate Cell Precursors and Methods of Isolating Same, Patent No. 7824911, IPC No. C12N 5/00 (20060101).
Kubota H, Reid LM, inventors. Hepatic Stellate Cell Precursors and Methods of Isolating Same. C12N 5/00 (20060101). 1800
Kubota, Hiroshi (Inventor) ; Reid, Lola M. (Inventor). / Hepatic Stellate Cell Precursors and Methods of Isolating Same. IPC No.: C12N 5/00 (20060101). Patent No.: 7824911.
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abstract = "The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1.sup.+, VCAM-1.sup.+, .beta.3-integrin.sup.+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle .alpha.-actin, nestin, hepatocyte growth factor, stromal derived factor-1.alpha. and H1x homeobox transcriptional factor.",
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AU - Reid,Lola M.

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PY - 1800

Y1 - 1800

N2 - The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1.sup.+, VCAM-1.sup.+, .beta.3-integrin.sup.+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle .alpha.-actin, nestin, hepatocyte growth factor, stromal derived factor-1.alpha. and H1x homeobox transcriptional factor.

AB - The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1.sup.+, VCAM-1.sup.+, .beta.3-integrin.sup.+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle .alpha.-actin, nestin, hepatocyte growth factor, stromal derived factor-1.alpha. and H1x homeobox transcriptional factor.

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