Heparin and Heparan Sulfate Binding Chimeric Vectors

Richard Jude Samulski (Inventor), Zhijian Wu (Inventor), Aravind Asokan (Inventor)

Research output: Patent

Abstract

The present invention is based on the finding that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. In some embodiments, a substitution of a single amino acid that is unique to the AAV6 capsid (Lys-531) among other AAVs that have been characterized to date can confer one or more desirable properties to other AAVs.
LanguageEnglish
Patent number7867484
IPCC12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101)
StatePublished - 1800

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Heparitin Sulfate
Patents and inventions
Heparin
Substitution reactions
Amino Acids

Keywords

    Cite this

    Samulski, R. J., Wu, Z., & Asokan, A. (1800). IPC No. C12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101). Heparin and Heparan Sulfate Binding Chimeric Vectors (Patent No. 7867484.)

    Heparin and Heparan Sulfate Binding Chimeric Vectors. / Samulski, Richard Jude (Inventor); Wu, Zhijian (Inventor); Asokan, Aravind (Inventor).

    IPC No.: C12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101). Patent No.: 7867484.

    Research output: Patent

    Samulski, RJ, Wu, Z & Asokan, A 1800, Heparin and Heparan Sulfate Binding Chimeric Vectors, Patent No. 7867484, IPC No. C12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101).
    Samulski RJ, Wu Z, Asokan A, inventors. Heparin and Heparan Sulfate Binding Chimeric Vectors. C12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101). 1800
    Samulski, Richard Jude (Inventor) ; Wu, Zhijian (Inventor) ; Asokan, Aravind (Inventor). / Heparin and Heparan Sulfate Binding Chimeric Vectors. IPC No.: C12N 15/00 (20060101); C12N 15/85 (20060101); C12N 15/86 (20060101); C12N 15/64 (20060101). Patent No.: 7867484.
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    abstract = "The present invention is based on the finding that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. In some embodiments, a substitution of a single amino acid that is unique to the AAV6 capsid (Lys-531) among other AAVs that have been characterized to date can confer one or more desirable properties to other AAVs.",
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    AU - Asokan,Aravind

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