Frailty and inflammatory markers in older adults with cancer

Tomohiro F. Nishijima, Allison M. Deal, Grant R. Williams, Emily J. Guerard, Kirsten A. Nyrop, Hyman B. Muss

Research output: Research - peer-reviewArticle

  • 3 Citations

Abstract

We examined the associations between frailty and inflammatory markers, in particular neutrophil lymphocyte ratio (NLR), in elderly cancer patients. We conducted cross-sectional analyses of data derived from the Carolina Seniors Registry (CSR), a database of geriatric assessments (GA) in older adults (≧65 years) with cancer. We included patients in the CSR who had a GA and complete blood count test before initiation of therapy. The primary outcome was frailty, determined using the 36-item Carolina Frailty Index (CFI). In our sample of 133 patients, the median age was 74, and 54% were robust, 22% were pre-frail, and 24% were frail. There was a significant positive correlation between CFI and NLR (r = 0.22, p = 0.025). In multivariable analysis, patients in the top tertile of NLR had an odds ratio of 3.8 (95% CI = 1.1-12.8) for frail/pre-frail status, adjusting for age, sex, race, education level, marital status, cancer type and stage. In bivariable analyses, higher NLR was associated with lower instrumental activity of daily living (IADL) score (p = 0.040) and prolonged timed up and go (p = 0.016). This study suggests an association between frailty and inflammation in older adults with cancer.

LanguageEnglish (US)
Pages650-664
Number of pages15
JournalAging
Volume9
Issue number3
DOIs
StatePublished - 2017

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Neutrophils
Lymphocytes
Neoplasms
Geriatric Assessment
Registries
Sex Education
Blood Cell Count
Marital Status
Hematologic Tests
Activities of Daily Living
Cross-Sectional Studies
Odds Ratio
Databases
Inflammation
Therapeutics

Keywords

  • Frailty
  • Inflammatory markers
  • Lymphocyte monocyte ratio (LMR)
  • Neutrophil lymphocyte ratio (NLR)
  • Older adults with cancer

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Nishijima, T. F., Deal, A. M., Williams, G. R., Guerard, E. J., Nyrop, K. A., & Muss, H. B. (2017). Frailty and inflammatory markers in older adults with cancer. Aging, 9(3), 650-664. DOI: 10.18632/aging.101162

Frailty and inflammatory markers in older adults with cancer. / Nishijima, Tomohiro F.; Deal, Allison M.; Williams, Grant R.; Guerard, Emily J.; Nyrop, Kirsten A.; Muss, Hyman B.

In: Aging, Vol. 9, No. 3, 2017, p. 650-664.

Research output: Research - peer-reviewArticle

Nishijima, TF, Deal, AM, Williams, GR, Guerard, EJ, Nyrop, KA & Muss, HB 2017, 'Frailty and inflammatory markers in older adults with cancer' Aging, vol 9, no. 3, pp. 650-664. DOI: 10.18632/aging.101162
Nishijima TF, Deal AM, Williams GR, Guerard EJ, Nyrop KA, Muss HB. Frailty and inflammatory markers in older adults with cancer. Aging. 2017;9(3):650-664. Available from, DOI: 10.18632/aging.101162
Nishijima, Tomohiro F. ; Deal, Allison M. ; Williams, Grant R. ; Guerard, Emily J. ; Nyrop, Kirsten A. ; Muss, Hyman B./ Frailty and inflammatory markers in older adults with cancer. In: Aging. 2017 ; Vol. 9, No. 3. pp. 650-664
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