Examination of cocaine dose in a preclinical model of natural reward devaluation by cocaine

Research output: Research - peer-reviewArticle

Abstract

In a preclinical model of natural reward devaluation by cocaine, taste cues elicit aversive taste reactivity when they predict impending but delayed cocaine self-administration. Here, we investigated this negative affective state as a function of cocaine dose. Male, Sprague-Dawley rats were given 45 brief intraoral infusions of a 0.15% saccharin solution before 2 h cocaine self-administration for 14 days. Rats were video recorded; taste reactivity and patterns of self-administration were quantified on the first and last days. On day 14, a significant decrease in appetitive taste reactivity and increase in aversive taste reactivity was observed (compared with day 1) that did not vary as a function of cocaine dose. In contrast, patterns of cocaine self-administration (i.e. the total number of lever presses and load-up behavior) varied as a function of dose across days. Further, load-up behavior was positively correlated with aversive taste reactivity (i.e. gapes) on day 14 across all doses tested. Collectively, these findings indicate that the emergence of negative affect in this preclinical model is not dependent on cocaine dose.

LanguageEnglish (US)
Pages398-402
Number of pages5
JournalBehavioural Pharmacology
Volume26
Issue number4
DOIs
StatePublished - Jul 22 2015

Fingerprint

Reward
Cocaine
Self Administration
Saccharin
Cues
Sprague Dawley Rats

Keywords

  • aversion
  • behavior
  • cocaine
  • rat

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Examination of cocaine dose in a preclinical model of natural reward devaluation by cocaine. / Green, Jennifer L.; Dykstra, Linda A.; Carelli, Regina M.

In: Behavioural Pharmacology, Vol. 26, No. 4, 22.07.2015, p. 398-402.

Research output: Research - peer-reviewArticle

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