Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity

Suzanne L. Pendl, Andrew P. Salzwedel, Barbara D. Goldman, Lisa F. Barrett, Weili Lin, John H. Gilmore, Wei Gao

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

The hierarchical nature of the brain's functional organization has long been recognized, but when and how this architecture emerges during development remains largely unknown. Here the development of the brain's hierarchical organization was characterized using a modified stepwise functional connectivity approach based on resting-state fMRI in a fully longitudinal sample of infants (N = 28, with scans after birth, and at 1 and 2 years) and adults. Results obtained by placing seeds in early sensory cortices revealed novel hierarchical patterns of adult brain organization ultimately converging in limbic, paralimbic, basal ganglia, and frontoparietal brain regions. These findings are remarkably consistent with predictive coding accounts of neural processing that place these regions at the top of predictive coding hierarchies. Infants gradually developed toward this architecture in a region- and step-dependent manner, and displayed many of the same regions as adults in top hierarchical positions, starting from 1 year of age. The findings further revealed patterns of inter-sensory connectivity likely reflecting the emergence and development of multisensory processing strategies during infancy, the strengths of which were correlated with early cognitive development scores. Hum Brain Mapp 38:2666–2682, 2017.

LanguageEnglish (US)
Pages2666-2682
Number of pages17
JournalHuman Brain Mapping
Volume38
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Brain
Basal Ganglia
Seeds
Magnetic Resonance Imaging
Parturition

Keywords

  • early brain development
  • hierarchical brain organization
  • predictive coding
  • sensory integration
  • stepwise functional connectivity

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Pendl, S. L., Salzwedel, A. P., Goldman, B. D., Barrett, L. F., Lin, W., Gilmore, J. H., & Gao, W. (2017). Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity. Human Brain Mapping, 38(5), 2666-2682. DOI: 10.1002/hbm.23552

Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity. / Pendl, Suzanne L.; Salzwedel, Andrew P.; Goldman, Barbara D.; Barrett, Lisa F.; Lin, Weili; Gilmore, John H.; Gao, Wei.

In: Human Brain Mapping, Vol. 38, No. 5, 01.05.2017, p. 2666-2682.

Research output: Contribution to journalArticle

Pendl, SL, Salzwedel, AP, Goldman, BD, Barrett, LF, Lin, W, Gilmore, JH & Gao, W 2017, 'Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity' Human Brain Mapping, vol 38, no. 5, pp. 2666-2682. DOI: 10.1002/hbm.23552
Pendl SL, Salzwedel AP, Goldman BD, Barrett LF, Lin W, Gilmore JH et al. Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity. Human Brain Mapping. 2017 May 1;38(5):2666-2682. Available from, DOI: 10.1002/hbm.23552
Pendl, Suzanne L. ; Salzwedel, Andrew P. ; Goldman, Barbara D. ; Barrett, Lisa F. ; Lin, Weili ; Gilmore, John H. ; Gao, Wei. / Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity. In: Human Brain Mapping. 2017 ; Vol. 38, No. 5. pp. 2666-2682
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