Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility

Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, Anne Z. Steiner

Research output: Research - peer-reviewArticle

  • 2 Citations

Abstract

Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30–44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24–0.90), but there was no correlation with TSH (r 0.02–0.15) or AMH (r −0.01 to −0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.

LanguageEnglish (US)
Pages53-59
Number of pages7
JournalReproductive Toxicology
Volume69
DOIs
StatePublished - Apr 1 2017

Fingerprint

Fertility
Thyroid Gland
Ovarian Reserve
Anti-Mullerian Hormone
Thyroid Hormones
Thyrotropin
Thyroxine
perfluorooctanoic acid
Endocrine Disruptors
Triiodothyronine
Proportional Hazards Models
Infertility
Pregnancy
Serum
perfluorooctane sulfonic acid
perfluorohexanesulfonic acid
perfluorononanoic acid

Keywords

  • Endocrine disrupting chemicals
  • Fecundability
  • Ovarian reserve
  • Perfluorinated chemicals
  • Thyroid hormones

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility. / Crawford, Natalie M.; Fenton, Suzanne E.; Strynar, Mark; Hines, Erin P.; Pritchard, David A.; Steiner, Anne Z.

In: Reproductive Toxicology, Vol. 69, 01.04.2017, p. 53-59.

Research output: Research - peer-reviewArticle

Crawford, Natalie M. ; Fenton, Suzanne E. ; Strynar, Mark ; Hines, Erin P. ; Pritchard, David A. ; Steiner, Anne Z./ Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility. In: Reproductive Toxicology. 2017 ; Vol. 69. pp. 53-59
@article{cc07e0fd5f7a4e46b9d9deccd3ce10f1,
title = "Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility",
abstract = "Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30–44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24–0.90), but there was no correlation with TSH (r 0.02–0.15) or AMH (r −0.01 to −0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.",
keywords = "Endocrine disrupting chemicals, Fecundability, Ovarian reserve, Perfluorinated chemicals, Thyroid hormones",
author = "Crawford, {Natalie M.} and Fenton, {Suzanne E.} and Mark Strynar and Hines, {Erin P.} and Pritchard, {David A.} and Steiner, {Anne Z.}",
year = "2017",
month = "4",
doi = "10.1016/j.reprotox.2017.01.006",
volume = "69",
pages = "53--59",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility

AU - Crawford,Natalie M.

AU - Fenton,Suzanne E.

AU - Strynar,Mark

AU - Hines,Erin P.

AU - Pritchard,David A.

AU - Steiner,Anne Z.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30–44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24–0.90), but there was no correlation with TSH (r 0.02–0.15) or AMH (r −0.01 to −0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.

AB - Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30–44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24–0.90), but there was no correlation with TSH (r 0.02–0.15) or AMH (r −0.01 to −0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.

KW - Endocrine disrupting chemicals

KW - Fecundability

KW - Ovarian reserve

KW - Perfluorinated chemicals

KW - Thyroid hormones

UR - http://www.scopus.com/inward/record.url?scp=85012248746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012248746&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2017.01.006

DO - 10.1016/j.reprotox.2017.01.006

M3 - Article

VL - 69

SP - 53

EP - 59

JO - Reproductive Toxicology

T2 - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -