Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision

Xin Wang, Hong Xie, Andrew S. Cotton, Kristopher R. Brickman, Terrence J. Lewis, John T. Wall, Marijo B. Tamburrino, William R. Bauer, Kenny Law, Samuel A. McLean, Israel Liberzon

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Abstract

Mild traumatic brain injury (mTBI) patients frequently experience emotion dysregulation symptoms, including post-traumatic stress. Although mTBI likely affects cortical activation and structure, resulting in cognitive symptoms after mTBI, early effects of mTBI on cortical emotion processing circuits have rarely been examined. To assess early mTBI effects on cortical functional and structural components of emotion processing, we assessed cortical activation to fearful faces within the first 2 weeks after motor vehicle collision (MVC) in survivors who did and did not experience mTBI. We also examined the thicknesses of cortical regions with altered activation. MVC survivors with mTBI (n = 21) had significantly less activation in left superior parietal gyrus (SPG) (-5.9, -81.8, 33.8; p = 10-3.623), left medial orbitofrontal gyrus (mOFG) (-4.7, 36.1, -19.3; p = 10-3.231), and left and right lateral orbitofrontal gyri (lOFG) (left: -16.0, 41.4, -16.6; p = 10-2.573; right: 18.7, 22.7, -17.7; p = 10-2.764) than MVC survivors without mTBI (n = 23). SPG activation in mTBI survivors within 2 weeks after MVC was negatively correlated with subsequent post-traumatic stress symptom severity at 3 months (r = -0.68, p = 0.03). Finally, the SPG region was thinner in the mTBI survivors than in the non-mTBI survivors (F = 11.07, p = 0.002). These results suggest that early differences in activation and structure in cortical emotion processing circuits in trauma survivors who sustain mTBI may contribute to the development of emotion-related symptoms.

LanguageEnglish (US)
Pages273-280
Number of pages8
JournalJournal of Neurotrauma
Volume34
Issue number2
DOIs
StatePublished - Jan 15 2017

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Brain Concussion
Motor Vehicles
Emotions
Survivors
Prefrontal Cortex
Neurobehavioral Manifestations
Parietal Lobe

Keywords

  • human studies
  • MRI, TBI

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Wang, X., Xie, H., Cotton, A. S., Brickman, K. R., Lewis, T. J., Wall, J. T., ... Liberzon, I. (2017). Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision. Journal of Neurotrauma, 34(2), 273-280. https://doi.org/10.1089/neu.2015.4392

Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision. / Wang, Xin; Xie, Hong; Cotton, Andrew S.; Brickman, Kristopher R.; Lewis, Terrence J.; Wall, John T.; Tamburrino, Marijo B.; Bauer, William R.; Law, Kenny; McLean, Samuel A.; Liberzon, Israel.

In: Journal of Neurotrauma, Vol. 34, No. 2, 15.01.2017, p. 273-280.

Research output: Contribution to journalArticle

Wang, X, Xie, H, Cotton, AS, Brickman, KR, Lewis, TJ, Wall, JT, Tamburrino, MB, Bauer, WR, Law, K, McLean, SA & Liberzon, I 2017, 'Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision' Journal of Neurotrauma, vol. 34, no. 2, pp. 273-280. https://doi.org/10.1089/neu.2015.4392
Wang, Xin ; Xie, Hong ; Cotton, Andrew S. ; Brickman, Kristopher R. ; Lewis, Terrence J. ; Wall, John T. ; Tamburrino, Marijo B. ; Bauer, William R. ; Law, Kenny ; McLean, Samuel A. ; Liberzon, Israel. / Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision. In: Journal of Neurotrauma. 2017 ; Vol. 34, No. 2. pp. 273-280.
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