Duplexed Parvovirus Vectors

Richard Jude Samulski (Inventor), Douglas M. McCarty (Inventor)

Research output: ResearchPatent

Abstract

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.
LanguageEnglish
Patent number8361457
IPCC12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101)
StatePublished - 1800

Fingerprint

Parvovirus
Genome
Capsid
Terminal Repeat Sequences
Base Pairing

Cite this

Samulski, R. J., & McCarty, D. M. (1800). IPC No. C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101). Duplexed Parvovirus Vectors (Patent No. 8361457.)

Duplexed Parvovirus Vectors. / Samulski, Richard Jude (Inventor); McCarty, Douglas M. (Inventor).

IPC No.: C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101). Patent No.: 8361457.

Research output: ResearchPatent

Samulski, RJ & McCarty, DM 1800, Duplexed Parvovirus Vectors, Patent No. 8361457, IPC No. C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101).
Samulski RJ, McCarty DM, inventors. Duplexed Parvovirus Vectors. C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101). 1800
Samulski, Richard Jude (Inventor) ; McCarty, Douglas M. (Inventor). / Duplexed Parvovirus Vectors. IPC No.: C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101). Patent No.: 8361457.
@misc{33f335e8d48e42a8a60587225a7a45b8,
title = "Duplexed Parvovirus Vectors",
abstract = "The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.",
author = "Samulski, {Richard Jude} and McCarty, {Douglas M.}",
note = "Status: published applicationnumber: 12/848,756 usclass: 424/93.1 ; 424/93.2; 424/93.21; 424/93.6; 435/455; 435/456; 435/91.4; 435/91.41; 435/91.42 applicationnumber: 12/848,756; 8361457; C12N 15/86 (20060101); C12N 15/00 (20060101); A61K 48/00 (20060101); C12N 15/64 (20060101)",
year = "1800",
type = "Patent",

}

TY - PAT

T1 - Duplexed Parvovirus Vectors

AU - Samulski,Richard Jude

AU - McCarty,Douglas M.

N1 - Status: published applicationnumber: 12/848,756 usclass: 424/93.1 ; 424/93.2; 424/93.21; 424/93.6; 435/455; 435/456; 435/91.4; 435/91.41; 435/91.42 applicationnumber: 12/848,756

PY - 1800

Y1 - 1800

N2 - The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

AB - The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

M3 - Patent

M1 - 8361457

ER -