Duplexed Parvovirus Vectors

Richard Jude Samulski (Inventor), Douglas M. (Chapel Hill McCarty (Inventor), [No Value] NC (Inventor)

Research output: ResearchPatent

Abstract

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.
LanguageEnglish
Patent number7790154
IPCC12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101)
StatePublished - 1800

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Parvovirus
Genome
Capsid
Terminal Repeat Sequences
Base Pairing

Keywords

    Cite this

    Samulski, R. J., McCarty, D. M. C. H., & NC, . N. V. (1800). IPC No. C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101). Duplexed Parvovirus Vectors (Patent No. 7790154.)

    Duplexed Parvovirus Vectors. / Samulski, Richard Jude (Inventor); McCarty, Douglas M. (Chapel Hill (Inventor); NC, [No Value] (Inventor).

    IPC No.: C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101). Patent No.: 7790154.

    Research output: ResearchPatent

    Samulski, RJ, McCarty, DMCH & NC, NV 1800, Duplexed Parvovirus Vectors, Patent No. 7790154, IPC No. C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101).
    Samulski RJ, McCarty DMCH, NC NV, inventors. Duplexed Parvovirus Vectors. C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101). 1800
    Samulski, Richard Jude (Inventor) ; McCarty, Douglas M. (Chapel Hill (Inventor) ; NC, [No Value] (Inventor). / Duplexed Parvovirus Vectors. IPC No.: C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101). Patent No.: 7790154.
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    abstract = "The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.",
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    author = "Samulski, {Richard Jude} and McCarty, {Douglas M. (Chapel Hill} and NC, {[No Value]}",
    note = "Status: published applicationnumber: 11/655,520 usclass: 424/93.1 ; 424/93.2; 424/93.21; 424/93.6; 435/455; 435/456; 435/91.4; 435/91.41; 435/91.42 applicationnumber: 11/655,520; 7790154; C12N 15/86 (20060101); C12N 15/00 (20060101); C12N 15/64 (20060101); A61K 48/00 (20060101)",
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    TY - PAT

    T1 - Duplexed Parvovirus Vectors

    AU - Samulski,Richard Jude

    AU - McCarty,Douglas M. (Chapel Hill

    AU - NC,[No Value]

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    PY - 1800

    Y1 - 1800

    N2 - The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

    AB - The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

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