Disrupted functional connectome in antisocial personality disorder

Weixiong Jiang, Feng Shi, Jian Liao, Huasheng Liu, Tao Wang, Celina Shen, Hui Shen, Dewen Hu, Wei Wang, Dinggang Shen

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.

LanguageEnglish (US)
Pages1071-1084
Number of pages14
JournalBrain Imaging and Behavior
Volume11
Issue number4
DOIs
StatePublished - Aug 1 2017

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Connectome
Antisocial Personality Disorder
Brain
Aptitude
Neuroimaging
Cognition

Keywords

  • Antisocial personality disorder
  • Brain connectome
  • Functional connectivity
  • Modularity
  • Topological organization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Disrupted functional connectome in antisocial personality disorder. / Jiang, Weixiong; Shi, Feng; Liao, Jian; Liu, Huasheng; Wang, Tao; Shen, Celina; Shen, Hui; Hu, Dewen; Wang, Wei; Shen, Dinggang.

In: Brain Imaging and Behavior, Vol. 11, No. 4, 01.08.2017, p. 1071-1084.

Research output: Contribution to journalArticle

Jiang, W, Shi, F, Liao, J, Liu, H, Wang, T, Shen, C, Shen, H, Hu, D, Wang, W & Shen, D 2017, 'Disrupted functional connectome in antisocial personality disorder' Brain Imaging and Behavior, vol. 11, no. 4, pp. 1071-1084. https://doi.org/10.1007/s11682-016-9572-z
Jiang, Weixiong ; Shi, Feng ; Liao, Jian ; Liu, Huasheng ; Wang, Tao ; Shen, Celina ; Shen, Hui ; Hu, Dewen ; Wang, Wei ; Shen, Dinggang. / Disrupted functional connectome in antisocial personality disorder. In: Brain Imaging and Behavior. 2017 ; Vol. 11, No. 4. pp. 1071-1084.
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