Disposable dosators for pulmonary insufflation of therapeutic agents to small animals

Phillip G. Durham, Shumaila N. Hanif, Lucia Garcia Contreras, Ellen F. Young, Miriam S. Braunstein, Anthony J. Hickey

Research output: Contribution to journalArticle

Abstract

Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration. While solutions exist to expose animals by passive inhalation to dry powder aerosols, most require masses of powder in large excess of the dose delivered. This precludes conducting early feasibility studies as insufficient drug is available at the research or early development stage to support the dose delivery requirements for conventional aerosol delivery systems. When designing an aerosol drug product, aerodynamic performance can relate directly to delivery efficiency and efficacy. Dispersion of powder into an aerosol requires energy input sufficient to overcome interparticulate forces, and particle engineering approaches can substantially improve aerosol performance. We have developed a dispersion system (dosator) which can aerosolize engineered dry powder aerosols efficiently for the purpose of direct pulmonary insufflation, dispersion into an exposure system or generation for analytical purposes.

LanguageEnglish (US)
Article numbere55356
JournalJournal of Visualized Experiments
Volume2017
Issue number121
DOIs
StatePublished - Mar 30 2017

Fingerprint

Insufflation
Aerosols
Animals
Powders
Lung
Therapeutics
Pharmaceutical Preparations
Feasibility Studies
Drug products
Inhalation
Particles (particulate matter)
Aerodynamics
Animal Models
Testing
Research

Keywords

  • Aerodynamic
  • Aerosol
  • Animal model
  • Dispersion
  • Dosator
  • Intrapulmonary
  • Issue 121
  • Medicine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Durham, P. G., Hanif, S. N., Contreras, L. G., Young, E. F., Braunstein, M. S., & Hickey, A. J. (2017). Disposable dosators for pulmonary insufflation of therapeutic agents to small animals. Journal of Visualized Experiments, 2017(121), [e55356]. DOI: 10.3791/55356

Disposable dosators for pulmonary insufflation of therapeutic agents to small animals. / Durham, Phillip G.; Hanif, Shumaila N.; Contreras, Lucia Garcia; Young, Ellen F.; Braunstein, Miriam S.; Hickey, Anthony J.

In: Journal of Visualized Experiments, Vol. 2017, No. 121, e55356, 30.03.2017.

Research output: Contribution to journalArticle

Durham, PG, Hanif, SN, Contreras, LG, Young, EF, Braunstein, MS & Hickey, AJ 2017, 'Disposable dosators for pulmonary insufflation of therapeutic agents to small animals' Journal of Visualized Experiments, vol 2017, no. 121, e55356. DOI: 10.3791/55356
Durham PG, Hanif SN, Contreras LG, Young EF, Braunstein MS, Hickey AJ. Disposable dosators for pulmonary insufflation of therapeutic agents to small animals. Journal of Visualized Experiments. 2017 Mar 30;2017(121). e55356. Available from, DOI: 10.3791/55356
Durham, Phillip G. ; Hanif, Shumaila N. ; Contreras, Lucia Garcia ; Young, Ellen F. ; Braunstein, Miriam S. ; Hickey, Anthony J./ Disposable dosators for pulmonary insufflation of therapeutic agents to small animals. In: Journal of Visualized Experiments. 2017 ; Vol. 2017, No. 121.
@article{c21fa641606e49bb8e77db6520019a99,
title = "Disposable dosators for pulmonary insufflation of therapeutic agents to small animals",
abstract = "Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration. While solutions exist to expose animals by passive inhalation to dry powder aerosols, most require masses of powder in large excess of the dose delivered. This precludes conducting early feasibility studies as insufficient drug is available at the research or early development stage to support the dose delivery requirements for conventional aerosol delivery systems. When designing an aerosol drug product, aerodynamic performance can relate directly to delivery efficiency and efficacy. Dispersion of powder into an aerosol requires energy input sufficient to overcome interparticulate forces, and particle engineering approaches can substantially improve aerosol performance. We have developed a dispersion system (dosator) which can aerosolize engineered dry powder aerosols efficiently for the purpose of direct pulmonary insufflation, dispersion into an exposure system or generation for analytical purposes.",
keywords = "Aerodynamic, Aerosol, Animal model, Dispersion, Dosator, Intrapulmonary, Issue 121, Medicine",
author = "Durham, {Phillip G.} and Hanif, {Shumaila N.} and Contreras, {Lucia Garcia} and Young, {Ellen F.} and Braunstein, {Miriam S.} and Hickey, {Anthony J.}",
year = "2017",
month = "3",
day = "30",
doi = "10.3791/55356",
language = "English (US)",
volume = "2017",
journal = "Journal of Visualized Experiments",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "121",

}

TY - JOUR

T1 - Disposable dosators for pulmonary insufflation of therapeutic agents to small animals

AU - Durham,Phillip G.

AU - Hanif,Shumaila N.

AU - Contreras,Lucia Garcia

AU - Young,Ellen F.

AU - Braunstein,Miriam S.

AU - Hickey,Anthony J.

PY - 2017/3/30

Y1 - 2017/3/30

N2 - Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration. While solutions exist to expose animals by passive inhalation to dry powder aerosols, most require masses of powder in large excess of the dose delivered. This precludes conducting early feasibility studies as insufficient drug is available at the research or early development stage to support the dose delivery requirements for conventional aerosol delivery systems. When designing an aerosol drug product, aerodynamic performance can relate directly to delivery efficiency and efficacy. Dispersion of powder into an aerosol requires energy input sufficient to overcome interparticulate forces, and particle engineering approaches can substantially improve aerosol performance. We have developed a dispersion system (dosator) which can aerosolize engineered dry powder aerosols efficiently for the purpose of direct pulmonary insufflation, dispersion into an exposure system or generation for analytical purposes.

AB - Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration. While solutions exist to expose animals by passive inhalation to dry powder aerosols, most require masses of powder in large excess of the dose delivered. This precludes conducting early feasibility studies as insufficient drug is available at the research or early development stage to support the dose delivery requirements for conventional aerosol delivery systems. When designing an aerosol drug product, aerodynamic performance can relate directly to delivery efficiency and efficacy. Dispersion of powder into an aerosol requires energy input sufficient to overcome interparticulate forces, and particle engineering approaches can substantially improve aerosol performance. We have developed a dispersion system (dosator) which can aerosolize engineered dry powder aerosols efficiently for the purpose of direct pulmonary insufflation, dispersion into an exposure system or generation for analytical purposes.

KW - Aerodynamic

KW - Aerosol

KW - Animal model

KW - Dispersion

KW - Dosator

KW - Intrapulmonary

KW - Issue 121

KW - Medicine

UR - http://www.scopus.com/inward/record.url?scp=85017119092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017119092&partnerID=8YFLogxK

U2 - 10.3791/55356

DO - 10.3791/55356

M3 - Article

VL - 2017

JO - Journal of Visualized Experiments

T2 - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

IS - 121

M1 - e55356

ER -