Direct C-H Cyanation of Arenes via Organic Photoredox Catalysis

Joshua B. McManus, David A. Nicewicz

Research output: Contribution to journalArticle

  • 22 Citations

Abstract

Methods for the direct C-H functionalization of aromatic compounds are in demand for a variety of applications, including the synthesis of agrochemicals, pharmaceuticals, and materials. Herein, we disclose the construction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. The reaction proceeds at room temperature under mild conditions and has proven to be compatible with a variety of electron-donating and -withdrawing groups, halogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceutical agents.

LanguageEnglish (US)
Pages2880-2883
Number of pages4
JournalJournal of the American chemical society
Volume139
Issue number8
DOIs
StatePublished - Mar 1 2017

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Catalysis
Drug products
Agrochemicals
Nitriles
Halogens
Aromatic compounds
Cyanides
Atmosphere
Pharmaceutical Preparations
Nitrogen
Electrons
Oxygen
Catalysts
Temperature
trimethylsilyl cyanide

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Direct C-H Cyanation of Arenes via Organic Photoredox Catalysis. / McManus, Joshua B.; Nicewicz, David A.

In: Journal of the American chemical society, Vol. 139, No. 8, 01.03.2017, p. 2880-2883.

Research output: Contribution to journalArticle

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