Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos

M. Larissa Avilés-Santa, Cynthia M. Pérez, Neil Schneiderman, Peter J. Savage, Robert C. Kaplan, Yanping Teng, Erick L. Suárez, Jianwen Cai, Aida L. Giachello, Gregory A. Talavera, Catherine C. Cowie

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A1c (HbA1c) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG = 5.6–7.0 mmol/L, 2hPG = 7.8–11.1 mmol/L, and HbA1c = 5.7%–6.4% (39–46 mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG < 5.6 mmol/L and 2hPG < 7.8 mmol/L and HbA1c < 5.7% (39 mmol/mol)]. Approximately 36% of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1%, HbA1c was 45.6%, and that of HbA1c + FPG was 62.2%. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG = 7.8–11.1 mmol/L, FPG = 5.6–7.0 mmol/L + HbA1c = 5.7%–6.4%, or those who met the three prediabetes criteria. Assessing FPG, HbA1c, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.

LanguageEnglish (US)
Pages110-118
Number of pages9
JournalPreventive Medicine
Volume95
DOIs
StatePublished - Feb 1 2017

Fingerprint

Prediabetic State
Hispanic Americans
Fasting
Glucose
Health
Hemoglobin A
Aptitude
Diabetes Complications
Diabetes Mellitus
Cross-Sectional Studies

Keywords

  • Hispanics
  • Hypertension
  • Latinos
  • LDL cholesterol
  • Obesity
  • Prediabetic state
  • Triglycerides

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Avilés-Santa, M. L., Pérez, C. M., Schneiderman, N., Savage, P. J., Kaplan, R. C., Teng, Y., ... Cowie, C. C. (2017). Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos. Preventive Medicine, 95, 110-118. DOI: 10.1016/j.ypmed.2016.12.009

Detecting prediabetes among Hispanics/Latinos from diverse heritage groups : Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos. / Avilés-Santa, M. Larissa; Pérez, Cynthia M.; Schneiderman, Neil; Savage, Peter J.; Kaplan, Robert C.; Teng, Yanping; Suárez, Erick L.; Cai, Jianwen; Giachello, Aida L.; Talavera, Gregory A.; Cowie, Catherine C.

In: Preventive Medicine, Vol. 95, 01.02.2017, p. 110-118.

Research output: Contribution to journalArticle

Avilés-Santa, ML, Pérez, CM, Schneiderman, N, Savage, PJ, Kaplan, RC, Teng, Y, Suárez, EL, Cai, J, Giachello, AL, Talavera, GA & Cowie, CC 2017, 'Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos' Preventive Medicine, vol 95, pp. 110-118. DOI: 10.1016/j.ypmed.2016.12.009
Avilés-Santa, M. Larissa ; Pérez, Cynthia M. ; Schneiderman, Neil ; Savage, Peter J. ; Kaplan, Robert C. ; Teng, Yanping ; Suárez, Erick L. ; Cai, Jianwen ; Giachello, Aida L. ; Talavera, Gregory A. ; Cowie, Catherine C./ Detecting prediabetes among Hispanics/Latinos from diverse heritage groups : Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos. In: Preventive Medicine. 2017 ; Vol. 95. pp. 110-118
@article{1930eafa851240f5b729cc874e4b72a2,
title = "Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos",
abstract = "The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A1c (HbA1c) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG = 5.6–7.0 mmol/L, 2hPG = 7.8–11.1 mmol/L, and HbA1c = 5.7{\%}–6.4{\%} (39–46 mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG < 5.6 mmol/L and 2hPG < 7.8 mmol/L and HbA1c < 5.7{\%} (39 mmol/mol)]. Approximately 36{\%} of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1{\%}, HbA1c was 45.6{\%}, and that of HbA1c + FPG was 62.2{\%}. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG = 7.8–11.1 mmol/L, FPG = 5.6–7.0 mmol/L + HbA1c = 5.7{\%}–6.4{\%}, or those who met the three prediabetes criteria. Assessing FPG, HbA1c, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.",
keywords = "Hispanics, Hypertension, Latinos, LDL cholesterol, Obesity, Prediabetic state, Triglycerides",
author = "Avil{\'e}s-Santa, {M. Larissa} and P{\'e}rez, {Cynthia M.} and Neil Schneiderman and Savage, {Peter J.} and Kaplan, {Robert C.} and Yanping Teng and Su{\'a}rez, {Erick L.} and Jianwen Cai and Giachello, {Aida L.} and Talavera, {Gregory A.} and Cowie, {Catherine C.}",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.ypmed.2016.12.009",
language = "English (US)",
volume = "95",
pages = "110--118",
journal = "Preventive Medicine",
issn = "0091-7435",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Detecting prediabetes among Hispanics/Latinos from diverse heritage groups

T2 - Preventive Medicine

AU - Avilés-Santa,M. Larissa

AU - Pérez,Cynthia M.

AU - Schneiderman,Neil

AU - Savage,Peter J.

AU - Kaplan,Robert C.

AU - Teng,Yanping

AU - Suárez,Erick L.

AU - Cai,Jianwen

AU - Giachello,Aida L.

AU - Talavera,Gregory A.

AU - Cowie,Catherine C.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A1c (HbA1c) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG = 5.6–7.0 mmol/L, 2hPG = 7.8–11.1 mmol/L, and HbA1c = 5.7%–6.4% (39–46 mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG < 5.6 mmol/L and 2hPG < 7.8 mmol/L and HbA1c < 5.7% (39 mmol/mol)]. Approximately 36% of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1%, HbA1c was 45.6%, and that of HbA1c + FPG was 62.2%. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG = 7.8–11.1 mmol/L, FPG = 5.6–7.0 mmol/L + HbA1c = 5.7%–6.4%, or those who met the three prediabetes criteria. Assessing FPG, HbA1c, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.

AB - The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A1c (HbA1c) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG = 5.6–7.0 mmol/L, 2hPG = 7.8–11.1 mmol/L, and HbA1c = 5.7%–6.4% (39–46 mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG < 5.6 mmol/L and 2hPG < 7.8 mmol/L and HbA1c < 5.7% (39 mmol/mol)]. Approximately 36% of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1%, HbA1c was 45.6%, and that of HbA1c + FPG was 62.2%. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG = 7.8–11.1 mmol/L, FPG = 5.6–7.0 mmol/L + HbA1c = 5.7%–6.4%, or those who met the three prediabetes criteria. Assessing FPG, HbA1c, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.

KW - Hispanics

KW - Hypertension

KW - Latinos

KW - LDL cholesterol

KW - Obesity

KW - Prediabetic state

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=85007124586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007124586&partnerID=8YFLogxK

U2 - 10.1016/j.ypmed.2016.12.009

DO - 10.1016/j.ypmed.2016.12.009

M3 - Article

VL - 95

SP - 110

EP - 118

JO - Preventive Medicine

JF - Preventive Medicine

SN - 0091-7435

ER -