Deregulated miRNAs in human cervical cancer: Functional importance and potential clinical use

Jing Li, Qiuli Liu, Leslie H. Clark, Haifeng Qiu, Victoria L. Bae-Jump, Chunxiao Zhou

Research output: Contribution to journalReview article

  • 5 Citations

Abstract

Cervical cancer (CC) is one of the most common malignancies affecting women worldwide. While the morbidity and mortality associated with CC are decreasing in western countries, they both remain high in developing countries. Unfortunately, many issues about molecular mechanisms of CC are not clear yet. miRNAs are a group of small noncoding RNAs that could post-transcriptionally modulate the expression of specific genes and participate in the initiation and progression of multiple diseases including CC. In the last decade, mounting evidences suggest an association between miRNAs and human papillomavirus infection, as well as variations in biologic behavior, treatment response and prognosis in CC. Herein, we highlight the latest findings in this area and the potential applications.

LanguageEnglish (US)
Pages743-753
Number of pages11
JournalFuture Oncology
Volume13
Issue number8
DOIs
StatePublished - Apr 1 2017

Fingerprint

MicroRNAs
Uterine Cervical Neoplasms
Small Untranslated RNA
Papillomavirus Infections
Developing Countries
Disease Progression
Morbidity
Gene Expression
Mortality
Neoplasms
Therapeutics

Keywords

  • cervical cancer
  • HPV infection
  • miRNA
  • prognosis
  • susceptibility

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Deregulated miRNAs in human cervical cancer : Functional importance and potential clinical use. / Li, Jing; Liu, Qiuli; Clark, Leslie H.; Qiu, Haifeng; Bae-Jump, Victoria L.; Zhou, Chunxiao.

In: Future Oncology, Vol. 13, No. 8, 01.04.2017, p. 743-753.

Research output: Contribution to journalReview article

Li, Jing ; Liu, Qiuli ; Clark, Leslie H. ; Qiu, Haifeng ; Bae-Jump, Victoria L. ; Zhou, Chunxiao. / Deregulated miRNAs in human cervical cancer : Functional importance and potential clinical use. In: Future Oncology. 2017 ; Vol. 13, No. 8. pp. 743-753
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