Cortical gray and subcortical white matter associations in Parkinson's disease

Nicholas W. Sterling, Guangwei Du, Mechelle M. Lewis, Steven Swavely, Lan Kong, Martin Styner, Xuemei Huang

Research output: Research - peer-reviewArticle

Abstract

Cortical atrophy has been documented in both Parkinson's disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline and 18 and 36 months, from which cortical volumes and underlying subcortical white matter axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these, underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (ps ≤ 0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (ps ≤ 0.0013) in 2 subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.

LanguageEnglish (US)
Pages100-108
Number of pages9
JournalNeurobiology of Aging
Volume49
DOIs
StatePublished - Jan 1 2017

Fingerprint

Parkinson Disease
White Matter
Anisotropy
Atrophy
Gray Matter

Keywords

  • Cortical atrophy
  • Diffusion-tensor imaging
  • Myelin
  • Parkinson's disease
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Sterling, N. W., Du, G., Lewis, M. M., Swavely, S., Kong, L., Styner, M., & Huang, X. (2017). Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiology of Aging, 49, 100-108. DOI: 10.1016/j.neurobiolaging.2016.09.015

Cortical gray and subcortical white matter associations in Parkinson's disease. / Sterling, Nicholas W.; Du, Guangwei; Lewis, Mechelle M.; Swavely, Steven; Kong, Lan; Styner, Martin; Huang, Xuemei.

In: Neurobiology of Aging, Vol. 49, 01.01.2017, p. 100-108.

Research output: Research - peer-reviewArticle

Sterling, NW, Du, G, Lewis, MM, Swavely, S, Kong, L, Styner, M & Huang, X 2017, 'Cortical gray and subcortical white matter associations in Parkinson's disease' Neurobiology of Aging, vol 49, pp. 100-108. DOI: 10.1016/j.neurobiolaging.2016.09.015
Sterling NW, Du G, Lewis MM, Swavely S, Kong L, Styner M et al. Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiology of Aging. 2017 Jan 1;49:100-108. Available from, DOI: 10.1016/j.neurobiolaging.2016.09.015
Sterling, Nicholas W. ; Du, Guangwei ; Lewis, Mechelle M. ; Swavely, Steven ; Kong, Lan ; Styner, Martin ; Huang, Xuemei. / Cortical gray and subcortical white matter associations in Parkinson's disease. In: Neurobiology of Aging. 2017 ; Vol. 49. pp. 100-108
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