Contrasting regulation of catecholamine neurotransmission in the behaving Brain: Pharmacological insights from an electrochemical perspective

Megan E. Fox, R. Mark Wightman

Research output: Contribution to journalArticle

  • 4 Citations

Abstract

Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated inboth neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.

LanguageEnglish (US)
Pages12-32
Number of pages21
JournalPharmacological reviews
Volume69
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Synaptic Transmission
Catecholamines
Pharmacology
Brain
Electrochemistry
Neurodegenerative Diseases
Dopamine
Norepinephrine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

@article{c3bb33b58da342e28d99df097a6c2704,
title = "Contrasting regulation of catecholamine neurotransmission in the behaving Brain: Pharmacological insights from an electrochemical perspective",
abstract = "Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated inboth neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.",
author = "Fox, {Megan E.} and Wightman, {R. Mark}",
year = "2017",
month = "1",
day = "1",
doi = "10.1124/pr.116.012948",
language = "English (US)",
volume = "69",
pages = "12--32",
journal = "Pharmacological Reviews",
issn = "0031-6997",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "1",

}

TY - JOUR

T1 - Contrasting regulation of catecholamine neurotransmission in the behaving Brain

T2 - Pharmacological Reviews

AU - Fox,Megan E.

AU - Wightman,R. Mark

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated inboth neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.

AB - Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated inboth neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.

UR - http://www.scopus.com/inward/record.url?scp=85006056279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006056279&partnerID=8YFLogxK

U2 - 10.1124/pr.116.012948

DO - 10.1124/pr.116.012948

M3 - Article

VL - 69

SP - 12

EP - 32

JO - Pharmacological Reviews

JF - Pharmacological Reviews

SN - 0031-6997

IS - 1

ER -