Contrast enhanced superharmonic imaging for acoustic angiography using reduced form-factor lateral mode transmitters for intravascular and intracavity applications

Zhuochen Wang, K. Heath Martin, Wenbin Huang, Paul A. Dayton, Xiaoning Jiang

Research output: Research - peer-reviewArticle

  • 4 Citations

Abstract

Techniques to image the microvasculature may play an important role in imaging tumor-related angiogenesis and vasa vasorum associated with vulnerable atherosclerotic plaques. However, the microvasculature associated with these pathologies is difficult to detect using traditional B-mode ultrasound or even harmonic imaging due to small vessel size and poor differentiation from surrounding tissue. Acoustic angiography, a microvascular imaging technique that utilizes superharmonic imaging (detection of higher order harmonics of microbubble response), can yield a much higher contrast-to-tissue ratio than second harmonic imaging methods. In this paper, two dual-frequency transducers using lateral mode transmitters were developed for superharmonic detection and acoustic angiography imaging in intracavity applications. A single element dual-frequency intravascular ultrasound transducer was developed for concept validation, which achieved larger signal amplitude, better contrast-to-noise ratio (CNR), and pulselength compared to the previous work. A dual-frequency [Pb(Mg1/3Nb2/3)O3]-x[PbTiO3] array transducer was then developed for superharmonic imaging with dynamic focusing. The axial and lateral sizes of the microbubbles in a 200-μm tube were measured to be 269 and 200μm, respectively. The maximum CNR was calculated to be 22 dB. These results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices.

LanguageEnglish (US)
Article number7604089
Pages311-319
Number of pages9
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume64
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

superharmonics
angiography
transmitters
form factors
transducers
acoustics
Angiography
Transmitters
Acoustics
Imaging techniques
harmonics
Transducers
angiogenesis
pathology
imaging techniques
vessels
tumors
tubes
low frequencies
requirements

Keywords

  • Dual frequency
  • lateral mode transducer
  • superharmonic
  • ultrasound transducer

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

Cite this

Contrast enhanced superharmonic imaging for acoustic angiography using reduced form-factor lateral mode transmitters for intravascular and intracavity applications. / Wang, Zhuochen; Martin, K. Heath; Huang, Wenbin; Dayton, Paul A.; Jiang, Xiaoning.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 64, No. 2, 7604089, 01.02.2017, p. 311-319.

Research output: Research - peer-reviewArticle

@article{d23a3a173c3c4e2298f9f6d38924f3da,
title = "Contrast enhanced superharmonic imaging for acoustic angiography using reduced form-factor lateral mode transmitters for intravascular and intracavity applications",
abstract = "Techniques to image the microvasculature may play an important role in imaging tumor-related angiogenesis and vasa vasorum associated with vulnerable atherosclerotic plaques. However, the microvasculature associated with these pathologies is difficult to detect using traditional B-mode ultrasound or even harmonic imaging due to small vessel size and poor differentiation from surrounding tissue. Acoustic angiography, a microvascular imaging technique that utilizes superharmonic imaging (detection of higher order harmonics of microbubble response), can yield a much higher contrast-to-tissue ratio than second harmonic imaging methods. In this paper, two dual-frequency transducers using lateral mode transmitters were developed for superharmonic detection and acoustic angiography imaging in intracavity applications. A single element dual-frequency intravascular ultrasound transducer was developed for concept validation, which achieved larger signal amplitude, better contrast-to-noise ratio (CNR), and pulselength compared to the previous work. A dual-frequency [Pb(Mg1/3Nb2/3)O3]-x[PbTiO3] array transducer was then developed for superharmonic imaging with dynamic focusing. The axial and lateral sizes of the microbubbles in a 200-μm tube were measured to be 269 and 200μm, respectively. The maximum CNR was calculated to be 22 dB. These results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices.",
keywords = "Dual frequency, lateral mode transducer, superharmonic, ultrasound transducer",
author = "Zhuochen Wang and Martin, {K. Heath} and Wenbin Huang and Dayton, {Paul A.} and Xiaoning Jiang",
year = "2017",
month = "2",
doi = "10.1109/TUFFC.2016.2619687",
volume = "64",
pages = "311--319",
journal = "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control",
issn = "0885-3010",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "2",

}

TY - JOUR

T1 - Contrast enhanced superharmonic imaging for acoustic angiography using reduced form-factor lateral mode transmitters for intravascular and intracavity applications

AU - Wang,Zhuochen

AU - Martin,K. Heath

AU - Huang,Wenbin

AU - Dayton,Paul A.

AU - Jiang,Xiaoning

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Techniques to image the microvasculature may play an important role in imaging tumor-related angiogenesis and vasa vasorum associated with vulnerable atherosclerotic plaques. However, the microvasculature associated with these pathologies is difficult to detect using traditional B-mode ultrasound or even harmonic imaging due to small vessel size and poor differentiation from surrounding tissue. Acoustic angiography, a microvascular imaging technique that utilizes superharmonic imaging (detection of higher order harmonics of microbubble response), can yield a much higher contrast-to-tissue ratio than second harmonic imaging methods. In this paper, two dual-frequency transducers using lateral mode transmitters were developed for superharmonic detection and acoustic angiography imaging in intracavity applications. A single element dual-frequency intravascular ultrasound transducer was developed for concept validation, which achieved larger signal amplitude, better contrast-to-noise ratio (CNR), and pulselength compared to the previous work. A dual-frequency [Pb(Mg1/3Nb2/3)O3]-x[PbTiO3] array transducer was then developed for superharmonic imaging with dynamic focusing. The axial and lateral sizes of the microbubbles in a 200-μm tube were measured to be 269 and 200μm, respectively. The maximum CNR was calculated to be 22 dB. These results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices.

AB - Techniques to image the microvasculature may play an important role in imaging tumor-related angiogenesis and vasa vasorum associated with vulnerable atherosclerotic plaques. However, the microvasculature associated with these pathologies is difficult to detect using traditional B-mode ultrasound or even harmonic imaging due to small vessel size and poor differentiation from surrounding tissue. Acoustic angiography, a microvascular imaging technique that utilizes superharmonic imaging (detection of higher order harmonics of microbubble response), can yield a much higher contrast-to-tissue ratio than second harmonic imaging methods. In this paper, two dual-frequency transducers using lateral mode transmitters were developed for superharmonic detection and acoustic angiography imaging in intracavity applications. A single element dual-frequency intravascular ultrasound transducer was developed for concept validation, which achieved larger signal amplitude, better contrast-to-noise ratio (CNR), and pulselength compared to the previous work. A dual-frequency [Pb(Mg1/3Nb2/3)O3]-x[PbTiO3] array transducer was then developed for superharmonic imaging with dynamic focusing. The axial and lateral sizes of the microbubbles in a 200-μm tube were measured to be 269 and 200μm, respectively. The maximum CNR was calculated to be 22 dB. These results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices.

KW - Dual frequency

KW - lateral mode transducer

KW - superharmonic

KW - ultrasound transducer

UR - http://www.scopus.com/inward/record.url?scp=85012868727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012868727&partnerID=8YFLogxK

U2 - 10.1109/TUFFC.2016.2619687

DO - 10.1109/TUFFC.2016.2619687

M3 - Article

VL - 64

SP - 311

EP - 319

JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

T2 - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

SN - 0885-3010

IS - 2

M1 - 7604089

ER -