Construction and characterisation of a heparan sulphate heptasaccharide microarray

Jianhong Yang, Po Hung Hsieh, Xinyue Liu, Wen Zhou, Xing Zhang, Jing Zhao, Yongmei Xu, Fuming Zhang, Robert J. Linhardt, Jian Liu

Research output: Contribution to journalArticle

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Abstract

A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

LanguageEnglish (US)
Pages1743-1746
Number of pages4
JournalChemical Communications
Volume53
Issue number10
DOIs
StatePublished - Jan 1 2017

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Heparitin Sulfate
Microarrays
Sulfotransferases
Antithrombins
Polysaccharides
Carrier Proteins
Sulfates
Proteins

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Yang, J., Hsieh, P. H., Liu, X., Zhou, W., Zhang, X., Zhao, J., ... Liu, J. (2017). Construction and characterisation of a heparan sulphate heptasaccharide microarray. Chemical Communications, 53(10), 1743-1746. DOI: 10.1039/c6cc08204a

Construction and characterisation of a heparan sulphate heptasaccharide microarray. / Yang, Jianhong; Hsieh, Po Hung; Liu, Xinyue; Zhou, Wen; Zhang, Xing; Zhao, Jing; Xu, Yongmei; Zhang, Fuming; Linhardt, Robert J.; Liu, Jian.

In: Chemical Communications, Vol. 53, No. 10, 01.01.2017, p. 1743-1746.

Research output: Contribution to journalArticle

Yang, J, Hsieh, PH, Liu, X, Zhou, W, Zhang, X, Zhao, J, Xu, Y, Zhang, F, Linhardt, RJ & Liu, J 2017, 'Construction and characterisation of a heparan sulphate heptasaccharide microarray' Chemical Communications, vol. 53, no. 10, pp. 1743-1746. DOI: 10.1039/c6cc08204a
Yang J, Hsieh PH, Liu X, Zhou W, Zhang X, Zhao J et al. Construction and characterisation of a heparan sulphate heptasaccharide microarray. Chemical Communications. 2017 Jan 1;53(10):1743-1746. Available from, DOI: 10.1039/c6cc08204a
Yang, Jianhong ; Hsieh, Po Hung ; Liu, Xinyue ; Zhou, Wen ; Zhang, Xing ; Zhao, Jing ; Xu, Yongmei ; Zhang, Fuming ; Linhardt, Robert J. ; Liu, Jian. / Construction and characterisation of a heparan sulphate heptasaccharide microarray. In: Chemical Communications. 2017 ; Vol. 53, No. 10. pp. 1743-1746
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