Concordance of haemoglobin A1c, blood pressure and C-reactive protein between children and their parents in Chinese households

F. Dong, A. G. Howard, A. H. Herring, L. S. Adair, A. L. Thompson, B. M. Popkin, A. E. Aiello, B. Zhang, P. Gordon-Larsen

Research output: Contribution to journalArticle

Abstract

Background: China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown. Objectives: The objective of the study is to examine the parent–child association for haemoglobin A1c (HbA1c), blood pressure (BP) and C-reactive protein (CRP) in a large, geographically diverse Chinese sample. Methods: In 940 parent–child pairs (children aged 7–17 years) who participated in the 2009 China Health and Nutrition Survey, we measured each individual's HbA1c and CRP using fasting blood and BP. We used sex-specific random-effects linear regression to examine the parent–child association for these risk factors, accounting for within-family clustering. Results: Child's HbA1c was positively associated with parental HbA1c. Beta coefficients ranged from 0.06 (95% CI 0.03–0.12) for father–daughter to 0.43 (95% CI 0.28–0.58) for mother–son pairs. We also detected a positive mother–daughter association for BP and positive father–child associations for CRP. Conclusion: The statistically significant parent–child association for HbA1c, BP and CRP in Chinese families suggests that household-based interventions could be useful for confronting the high rates of diabetes, hypertension and inflammation in China.

LanguageEnglish (US)
Pages422-430
Number of pages9
JournalPediatric Obesity
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2017

Fingerprint

C-Reactive Protein
Hemoglobins
Parents
Blood Pressure
Nuclear Family
China
Fathers
Hemoglobin C
Mothers
Hypertension
Inflammation
Nutrition Surveys
Health Surveys
Cluster Analysis
Linear Models
Fasting

Keywords

  • Cardiometabolic risk factors
  • China
  • household structure
  • parent–offspring association
  • urbanization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Concordance of haemoglobin A1c, blood pressure and C-reactive protein between children and their parents in Chinese households. / Dong, F.; Howard, A. G.; Herring, A. H.; Adair, L. S.; Thompson, A. L.; Popkin, B. M.; Aiello, A. E.; Zhang, B.; Gordon-Larsen, P.

In: Pediatric Obesity, Vol. 12, No. 5, 01.10.2017, p. 422-430.

Research output: Contribution to journalArticle

@article{4afb2618902b404bb55f029fea8a7a00,
title = "Concordance of haemoglobin A1c, blood pressure and C-reactive protein between children and their parents in Chinese households",
abstract = "Background: China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown. Objectives: The objective of the study is to examine the parent–child association for haemoglobin A1c (HbA1c), blood pressure (BP) and C-reactive protein (CRP) in a large, geographically diverse Chinese sample. Methods: In 940 parent–child pairs (children aged 7–17 years) who participated in the 2009 China Health and Nutrition Survey, we measured each individual's HbA1c and CRP using fasting blood and BP. We used sex-specific random-effects linear regression to examine the parent–child association for these risk factors, accounting for within-family clustering. Results: Child's HbA1c was positively associated with parental HbA1c. Beta coefficients ranged from 0.06 (95{\%} CI 0.03–0.12) for father–daughter to 0.43 (95{\%} CI 0.28–0.58) for mother–son pairs. We also detected a positive mother–daughter association for BP and positive father–child associations for CRP. Conclusion: The statistically significant parent–child association for HbA1c, BP and CRP in Chinese families suggests that household-based interventions could be useful for confronting the high rates of diabetes, hypertension and inflammation in China.",
keywords = "Cardiometabolic risk factors, China, household structure, parent–offspring association, urbanization",
author = "F. Dong and Howard, {A. G.} and Herring, {A. H.} and Adair, {L. S.} and Thompson, {A. L.} and Popkin, {B. M.} and Aiello, {A. E.} and B. Zhang and P. Gordon-Larsen",
year = "2017",
month = "10",
day = "1",
doi = "10.1111/ijpo.12160",
language = "English (US)",
volume = "12",
pages = "422--430",
journal = "Pediatric obesity",
issn = "2047-6302",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "5",

}

TY - JOUR

T1 - Concordance of haemoglobin A1c, blood pressure and C-reactive protein between children and their parents in Chinese households

AU - Dong,F.

AU - Howard,A. G.

AU - Herring,A. H.

AU - Adair,L. S.

AU - Thompson,A. L.

AU - Popkin,B. M.

AU - Aiello,A. E.

AU - Zhang,B.

AU - Gordon-Larsen,P.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown. Objectives: The objective of the study is to examine the parent–child association for haemoglobin A1c (HbA1c), blood pressure (BP) and C-reactive protein (CRP) in a large, geographically diverse Chinese sample. Methods: In 940 parent–child pairs (children aged 7–17 years) who participated in the 2009 China Health and Nutrition Survey, we measured each individual's HbA1c and CRP using fasting blood and BP. We used sex-specific random-effects linear regression to examine the parent–child association for these risk factors, accounting for within-family clustering. Results: Child's HbA1c was positively associated with parental HbA1c. Beta coefficients ranged from 0.06 (95% CI 0.03–0.12) for father–daughter to 0.43 (95% CI 0.28–0.58) for mother–son pairs. We also detected a positive mother–daughter association for BP and positive father–child associations for CRP. Conclusion: The statistically significant parent–child association for HbA1c, BP and CRP in Chinese families suggests that household-based interventions could be useful for confronting the high rates of diabetes, hypertension and inflammation in China.

AB - Background: China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown. Objectives: The objective of the study is to examine the parent–child association for haemoglobin A1c (HbA1c), blood pressure (BP) and C-reactive protein (CRP) in a large, geographically diverse Chinese sample. Methods: In 940 parent–child pairs (children aged 7–17 years) who participated in the 2009 China Health and Nutrition Survey, we measured each individual's HbA1c and CRP using fasting blood and BP. We used sex-specific random-effects linear regression to examine the parent–child association for these risk factors, accounting for within-family clustering. Results: Child's HbA1c was positively associated with parental HbA1c. Beta coefficients ranged from 0.06 (95% CI 0.03–0.12) for father–daughter to 0.43 (95% CI 0.28–0.58) for mother–son pairs. We also detected a positive mother–daughter association for BP and positive father–child associations for CRP. Conclusion: The statistically significant parent–child association for HbA1c, BP and CRP in Chinese families suggests that household-based interventions could be useful for confronting the high rates of diabetes, hypertension and inflammation in China.

KW - Cardiometabolic risk factors

KW - China

KW - household structure

KW - parent–offspring association

KW - urbanization

UR - http://www.scopus.com/inward/record.url?scp=84973560623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973560623&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12160

DO - 10.1111/ijpo.12160

M3 - Article

VL - 12

SP - 422

EP - 430

JO - Pediatric obesity

T2 - Pediatric obesity

JF - Pediatric obesity

SN - 2047-6302

IS - 5

ER -