Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence, Carrie Sougnez, Lee Lichtenstein, Kristian Cibulskis, Eric Lander, Stacey B. Gabriel, Gad Getz, Adrian Ally, Miruna Balasundaram, Inanc Birol, Reanne Bowlby, Denise Brooks, Yaron S.N. Butterfield, Rebecca Carlsen, Dean Cheng, Andy Chu, Noreen Dhalla, Ranabir Guin, Robert A. Holt, Steven J.M. Jones & 291 others Darlene Lee, Haiyan I. Li, Marco A. Marra, Michael Mayo, Richard A. Moore, Andrew J. Mungall, A. Gordon Robertson, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Alexei Protopopov, Netty Santoso, Semin Lee, Michael Parfenov, Jianhua Zhang, Harshad S. Mahadeshwar, Jiabin Tang, Xiaojia Ren, Sahil Seth, Psalm Haseley, Dong Zeng, Lixing Yang, Andrew W. Xu, Xingzhi Song, Angeliki Pantazi, Christopher A. Bristow, Angela Hadjipanayis, Jonathan Seidman, Lynda Chin, Peter J. Park, Raju Kucherlapati, Rehan Akbani, Tod Casasent, Wenbin Liu, Yiling Lu, Gordon Mills, Thomas Motter, John Weinstein, Lixia Diao, Jing Wang, You Hong Fan, Jinze Liu, Kai Wang, J. Todd Auman, Saianand Balu, Thomas Bodenheimer, Elizabeth Buda, D. Neil Hayes, Katherine A. Hoadley, Alan P. Hoyle, Stuart R. Jefferys, Corbin D. Jones, Patrick K. Kimes, Yufeng Liu, J. S. Marron, Shaowu Meng, Piotr A. Mieczkowski, Lisle E. Mose, Joel S. Parker, Charles M. Perou, Jan F. Prins, Jeffrey Roach, Yan Shi, Janae V. Simons, Darshan Singh, Matthew G. Soloway, Donghui Tan, Umadevi Veluvolu, Vonn Walter, Scot Waring, Matthew D. Wilkerson, Junyuan Wu, Ni Zhao, Andrew D. Cherniack, Peter S. Hammerman, Aaron D. Tward, Chandra Sekhar Pedamallu, Gordon Saksena, Joonil Jung, Akinyemi I. Ojesina, Scott L. Carter, Travis I. Zack, Steven E. Schumacher, Rameen Beroukhim, Samuel S. Freeman, Matthew Meyerson, Juok Cho, Michael S. Noble, Daniel DiCara, Hailei Zhang, David I. Heiman, Nils Gehlenborg, Doug Voet, Pei Lin, Scott Frazer, Petar Stojanov, Yingchun Liu, Lihua Zou, Jaegil Kim, Donna Muzny, Harsha Vardhan Doddapaneni, Christie Kovar, Jeff Reid, Donna Morton, Yi Han, Walker Hale, Hsu Chao, Kyle Chang, Jennifer A. Drummond, Richard A. Gibbs, Nipun Kakkar, David Wheeler, Liu Xi, Giovanni Ciriello, Marc Ladanyi, William Lee, Ricardo Ramirez, Chris Sander, Ronglai Shen, Rileen Sinha, Nils Weinhold, Barry S. Taylor, B. Arman Aksoy, Gideon Dresdner, Jianjiong Gao, Benjamin Gross, Anders Jacobsen, Boris Reva, Nikolaus Schultz, S. Onur Sumer, Yichao Sun, Timothy A. Chan, Luc G. Morris, Joshua Stuart, Stephen Benz, Sam Ng, Christopher Benz, Christina Yau, Stephen B. Baylin, Leslie Cope, Ludmila Danilova, James G. Herman, Moiz Bootwalla, Dennis T. Maglinte, Peter W. Laird, Timothy Triche, Daniel J. Weisenberger, David J. Van Den Berg, Nishant Agrawal, Justin Bishop, Paul C. Boutros, Jeff P. Bruce, Lauren Averett Byers, Joseph Califano, Thomas E. Carey, Zhong Chen, Hui Cheng, Simion I. Chiosea, Ezra Cohen, Brenda Diergaarde, Ann Marie Egloff, Adel K. El-Naggar, Robert L. Ferris, Mitchell J. Frederick, Jennifer R. Grandis, Yan Guo, Robert I. Haddad, Thomas Harris, Angela B.Y. Hui, J. Jack Lee, Scott M. Lippman, Fei Fei Liu, Jonathan B. McHugh, Jeff Myers, Patrick Kwok Shing Ng, Bayardo Perez-Ordonez, Curtis R. Pickering, Michael Prystowsky, Marjorie Romkes, Anthony D. Saleh, Maureen A. Sartor, Raja Seethala, Tanguy Y. Seiwert, Han Si, Carter Van Waes, Daryl M. Waggott, Maciej Wiznerowicz, Wendell G. Yarbrough, Jiexin Zhang, Zhixiang Zuo, Ken Burnett, Daniel Crain, Johanna Gardner, Kevin Lau, David Mallery, Scott Morris, Joseph Paulauskis, Robert Penny, Candace Shelton, Troy Shelton, Mark Sherman, Peggy Yena, Aaron D. Black, Jay Bowen, Jessica Frick, Julie M. Gastier-Foster, Hollie A. Harper, Kristen Leraas, Tara M. Lichtenberg, Nilsa C. Ramirez, Lisa Wise, Erik Zmuda, Julien Baboud, Mark A. Jensen, Ari B. Kahn, Todd D. Pihl, David A. Pot, Deepak Srinivasan, Jessica S. Walton, Yunhu Wan, Robert A. Burton, Tanja Davidsen, John A. Demchok, Greg Eley, Martin L. Ferguson, Kenna R. Mills Shaw, Bradley A. Ozenberger, Margi Sheth, Heidi J. Sofia, Roy Tarnuzzer, Zhining Wang, Liming Yang, Jean Claude Zenklusen, Charles Saller, Katherine Tarvin, Chu Chen, Roni Bollag, Paul Weinberger, Wojciech Golusiński, Paweł Golusiński, Matthew Ibbs, Konstanty Korski, Andrzej Mackiewicz, Wiktoria Suchorska, Bartosz Szybiak, Erin Curley, Christina Beard, Colleen Mitchell, George Sandusky, Julie Ahn, Zubair Khan, Jonathan Irish, John Waldron, William N. William, Sophie Egea, Carmen Gomez-Fernandez, Lynn Herbert, Carol R. Bradford, Douglas B. Chepeha, Andrea S. Haddad, Tamara R. Jones, Christine M. Komarck, Mayya Malakh, Jeffrey S. Moyer, Ariane Nguyen, Lisa A. Peterson, Mark E. Prince, Laura S. Rozek, Evan G. Taylor, Heather M. Walline, Gregory T. Wolf, Lori Boice, Bhishamjit S. Chera, William K. Funkhouser, Margaret L. Gulley, Trevor G. Hackman, Michele C. Hayward, Mei Huang, W. Kimryn Rathmell, Ashley H. Salazar, William W. Shockley, Carol G. Shores, Leigh Thorne, Mark C. Weissler, Sylvia Wrenn, Adam M. Zanation, Brandee T. Brown, Michelle Pham,

Research output: Research - peer-reviewArticle

  • 646 Citations

Abstract

The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.

LanguageEnglish (US)
Pages576-582
Number of pages7
JournalNature
Volume517
Issue number7536
DOIs
StatePublished - Jan 29 2015

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Mutation
Neoplasms
Carcinoma, squamous cell of head and neck
TNF Receptor-Associated Factor 3
cdc Genes
Atlases
Oncogenes
Chromatin
Mouth
Oxidative Stress
Smoking
Genome
Genes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Lawrence, M. S., Sougnez, C., Lichtenstein, L., Cibulskis, K., Lander, E., Gabriel, S. B., ... The Cancer Genome Atlas Network (2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576-582. DOI: 10.1038/nature14129

Comprehensive genomic characterization of head and neck squamous cell carcinomas. / Lawrence, Michael S.; Sougnez, Carrie; Lichtenstein, Lee; Cibulskis, Kristian; Lander, Eric; Gabriel, Stacey B.; Getz, Gad; Ally, Adrian; Balasundaram, Miruna; Birol, Inanc; Bowlby, Reanne; Brooks, Denise; Butterfield, Yaron S.N.; Carlsen, Rebecca; Cheng, Dean; Chu, Andy; Dhalla, Noreen; Guin, Ranabir; Holt, Robert A.; Jones, Steven J.M.; Lee, Darlene; Li, Haiyan I.; Marra, Marco A.; Mayo, Michael; Moore, Richard A.; Mungall, Andrew J.; Robertson, A. Gordon; Schein, Jacqueline E.; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Wong, Tina; Protopopov, Alexei; Santoso, Netty; Lee, Semin; Parfenov, Michael; Zhang, Jianhua; Mahadeshwar, Harshad S.; Tang, Jiabin; Ren, Xiaojia; Seth, Sahil; Haseley, Psalm; Zeng, Dong; Yang, Lixing; Xu, Andrew W.; Song, Xingzhi; Pantazi, Angeliki; Bristow, Christopher A.; Hadjipanayis, Angela; Seidman, Jonathan; Chin, Lynda; Park, Peter J.; Kucherlapati, Raju; Akbani, Rehan; Casasent, Tod; Liu, Wenbin; Lu, Yiling; Mills, Gordon; Motter, Thomas; Weinstein, John; Diao, Lixia; Wang, Jing; Hong Fan, You; Liu, Jinze; Wang, Kai; Auman, J. Todd; Balu, Saianand; Bodenheimer, Thomas; Buda, Elizabeth; Hayes, D. Neil; Hoadley, Katherine A.; Hoyle, Alan P.; Jefferys, Stuart R.; Jones, Corbin D.; Kimes, Patrick K.; Liu, Yufeng; Marron, J. S.; Meng, Shaowu; Mieczkowski, Piotr A.; Mose, Lisle E.; Parker, Joel S.; Perou, Charles M.; Prins, Jan F.; Roach, Jeffrey; Shi, Yan; Simons, Janae V.; Singh, Darshan; Soloway, Matthew G.; Tan, Donghui; Veluvolu, Umadevi; Walter, Vonn; Waring, Scot; Wilkerson, Matthew D.; Wu, Junyuan; Zhao, Ni; Cherniack, Andrew D.; Hammerman, Peter S.; Tward, Aaron D.; Pedamallu, Chandra Sekhar; Saksena, Gordon; Jung, Joonil; Ojesina, Akinyemi I.; Carter, Scott L.; Zack, Travis I.; Schumacher, Steven E.; Beroukhim, Rameen; Freeman, Samuel S.; Meyerson, Matthew; Cho, Juok; Noble, Michael S.; DiCara, Daniel; Zhang, Hailei; Heiman, David I.; Gehlenborg, Nils; Voet, Doug; Lin, Pei; Frazer, Scott; Stojanov, Petar; Liu, Yingchun; Zou, Lihua; Kim, Jaegil; Muzny, Donna; Doddapaneni, Harsha Vardhan; Kovar, Christie; Reid, Jeff; Morton, Donna; Han, Yi; Hale, Walker; Chao, Hsu; Chang, Kyle; Drummond, Jennifer A.; Gibbs, Richard A.; Kakkar, Nipun; Wheeler, David; Xi, Liu; Ciriello, Giovanni; Ladanyi, Marc; Lee, William; Ramirez, Ricardo; Sander, Chris; Shen, Ronglai; Sinha, Rileen; Weinhold, Nils; Taylor, Barry S.; Aksoy, B. Arman; Dresdner, Gideon; Gao, Jianjiong; Gross, Benjamin; Jacobsen, Anders; Reva, Boris; Schultz, Nikolaus; Sumer, S. Onur; Sun, Yichao; Chan, Timothy A.; Morris, Luc G.; Stuart, Joshua; Benz, Stephen; Ng, Sam; Benz, Christopher; Yau, Christina; Baylin, Stephen B.; Cope, Leslie; Danilova, Ludmila; Herman, James G.; Bootwalla, Moiz; Maglinte, Dennis T.; Laird, Peter W.; Triche, Timothy; Weisenberger, Daniel J.; Van Den Berg, David J.; Agrawal, Nishant; Bishop, Justin; Boutros, Paul C.; Bruce, Jeff P.; Byers, Lauren Averett; Califano, Joseph; Carey, Thomas E.; Chen, Zhong; Cheng, Hui; Chiosea, Simion I.; Cohen, Ezra; Diergaarde, Brenda; Egloff, Ann Marie; El-Naggar, Adel K.; Ferris, Robert L.; Frederick, Mitchell J.; Grandis, Jennifer R.; Guo, Yan; Haddad, Robert I.; Harris, Thomas; Hui, Angela B.Y.; Lee, J. Jack; Lippman, Scott M.; Liu, Fei Fei; McHugh, Jonathan B.; Myers, Jeff; Ng, Patrick Kwok Shing; Perez-Ordonez, Bayardo; Pickering, Curtis R.; Prystowsky, Michael; Romkes, Marjorie; Saleh, Anthony D.; Sartor, Maureen A.; Seethala, Raja; Seiwert, Tanguy Y.; Si, Han; Van Waes, Carter; Waggott, Daryl M.; Wiznerowicz, Maciej; Yarbrough, Wendell G.; Zhang, Jiexin; Zuo, Zhixiang; Burnett, Ken; Crain, Daniel; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; Sherman, Mark; Yena, Peggy; Black, Aaron D.; Bowen, Jay; Frick, Jessica; Gastier-Foster, Julie M.; Harper, Hollie A.; Leraas, Kristen; Lichtenberg, Tara M.; Ramirez, Nilsa C.; Wise, Lisa; Zmuda, Erik; Baboud, Julien; Jensen, Mark A.; Kahn, Ari B.; Pihl, Todd D.; Pot, David A.; Srinivasan, Deepak; Walton, Jessica S.; Wan, Yunhu; Burton, Robert A.; Davidsen, Tanja; Demchok, John A.; Eley, Greg; Ferguson, Martin L.; Mills Shaw, Kenna R.; Ozenberger, Bradley A.; Sheth, Margi; Sofia, Heidi J.; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zenklusen, Jean Claude; Saller, Charles; Tarvin, Katherine; Chen, Chu; Bollag, Roni; Weinberger, Paul; Golusiński, Wojciech; Golusiński, Paweł; Ibbs, Matthew; Korski, Konstanty; Mackiewicz, Andrzej; Suchorska, Wiktoria; Szybiak, Bartosz; Curley, Erin; Beard, Christina; Mitchell, Colleen; Sandusky, George; Ahn, Julie; Khan, Zubair; Irish, Jonathan; Waldron, John; William, William N.; Egea, Sophie; Gomez-Fernandez, Carmen; Herbert, Lynn; Bradford, Carol R.; Chepeha, Douglas B.; Haddad, Andrea S.; Jones, Tamara R.; Komarck, Christine M.; Malakh, Mayya; Moyer, Jeffrey S.; Nguyen, Ariane; Peterson, Lisa A.; Prince, Mark E.; Rozek, Laura S.; Taylor, Evan G.; Walline, Heather M.; Wolf, Gregory T.; Boice, Lori; Chera, Bhishamjit S.; Funkhouser, William K.; Gulley, Margaret L.; Hackman, Trevor G.; Hayward, Michele C.; Huang, Mei; Rathmell, W. Kimryn; Salazar, Ashley H.; Shockley, William W.; Shores, Carol G.; Thorne, Leigh; Weissler, Mark C.; Wrenn, Sylvia; Zanation, Adam M.; Brown, Brandee T.; Pham, Michelle; The Cancer Genome Atlas Network.

In: Nature, Vol. 517, No. 7536, 29.01.2015, p. 576-582.

Research output: Research - peer-reviewArticle

Lawrence, MS, Sougnez, C, Lichtenstein, L, Cibulskis, K, Lander, E, Gabriel, SB, Getz, G, Ally, A, Balasundaram, M, Birol, I, Bowlby, R, Brooks, D, Butterfield, YSN, Carlsen, R, Cheng, D, Chu, A, Dhalla, N, Guin, R, Holt, RA, Jones, SJM, Lee, D, Li, HI, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Robertson, AG, Schein, JE, Sipahimalani, P, Tam, A, Thiessen, N, Wong, T, Protopopov, A, Santoso, N, Lee, S, Parfenov, M, Zhang, J, Mahadeshwar, HS, Tang, J, Ren, X, Seth, S, Haseley, P, Zeng, D, Yang, L, Xu, AW, Song, X, Pantazi, A, Bristow, CA, Hadjipanayis, A, Seidman, J, Chin, L, Park, PJ, Kucherlapati, R, Akbani, R, Casasent, T, Liu, W, Lu, Y, Mills, G, Motter, T, Weinstein, J, Diao, L, Wang, J, Hong Fan, Y, Liu, J, Wang, K, Auman, JT, Balu, S, Bodenheimer, T, Buda, E, Hayes, DN, Hoadley, KA, Hoyle, AP, Jefferys, SR, Jones, CD, Kimes, PK, Liu, Y, Marron, JS, Meng, S, Mieczkowski, PA, Mose, LE, Parker, JS, Perou, CM, Prins, JF, Roach, J, Shi, Y, Simons, JV, Singh, D, Soloway, MG, Tan, D, Veluvolu, U, Walter, V, Waring, S, Wilkerson, MD, Wu, J, Zhao, N, Cherniack, AD, Hammerman, PS, Tward, AD, Pedamallu, CS, Saksena, G, Jung, J, Ojesina, AI, Carter, SL, Zack, TI, Schumacher, SE, Beroukhim, R, Freeman, SS, Meyerson, M, Cho, J, Noble, MS, DiCara, D, Zhang, H, Heiman, DI, Gehlenborg, N, Voet, D, Lin, P, Frazer, S, Stojanov, P, Liu, Y, Zou, L, Kim, J, Muzny, D, Doddapaneni, HV, Kovar, C, Reid, J, Morton, D, Han, Y, Hale, W, Chao, H, Chang, K, Drummond, JA, Gibbs, RA, Kakkar, N, Wheeler, D, Xi, L, Ciriello, G, Ladanyi, M, Lee, W, Ramirez, R, Sander, C, Shen, R, Sinha, R, Weinhold, N, Taylor, BS, Aksoy, BA, Dresdner, G, Gao, J, Gross, B, Jacobsen, A, Reva, B, Schultz, N, Sumer, SO, Sun, Y, Chan, TA, Morris, LG, Stuart, J, Benz, S, Ng, S, Benz, C, Yau, C, Baylin, SB, Cope, L, Danilova, L, Herman, JG, Bootwalla, M, Maglinte, DT, Laird, PW, Triche, T, Weisenberger, DJ, Van Den Berg, DJ, Agrawal, N, Bishop, J, Boutros, PC, Bruce, JP, Byers, LA, Califano, J, Carey, TE, Chen, Z, Cheng, H, Chiosea, SI, Cohen, E, Diergaarde, B, Egloff, AM, El-Naggar, AK, Ferris, RL, Frederick, MJ, Grandis, JR, Guo, Y, Haddad, RI, Harris, T, Hui, ABY, Lee, JJ, Lippman, SM, Liu, FF, McHugh, JB, Myers, J, Ng, PKS, Perez-Ordonez, B, Pickering, CR, Prystowsky, M, Romkes, M, Saleh, AD, Sartor, MA, Seethala, R, Seiwert, TY, Si, H, Van Waes, C, Waggott, DM, Wiznerowicz, M, Yarbrough, WG, Zhang, J, Zuo, Z, Burnett, K, Crain, D, Gardner, J, Lau, K, Mallery, D, Morris, S, Paulauskis, J, Penny, R, Shelton, C, Shelton, T, Sherman, M, Yena, P, Black, AD, Bowen, J, Frick, J, Gastier-Foster, JM, Harper, HA, Leraas, K, Lichtenberg, TM, Ramirez, NC, Wise, L, Zmuda, E, Baboud, J, Jensen, MA, Kahn, AB, Pihl, TD, Pot, DA, Srinivasan, D, Walton, JS, Wan, Y, Burton, RA, Davidsen, T, Demchok, JA, Eley, G, Ferguson, ML, Mills Shaw, KR, Ozenberger, BA, Sheth, M, Sofia, HJ, Tarnuzzer, R, Wang, Z, Yang, L, Zenklusen, JC, Saller, C, Tarvin, K, Chen, C, Bollag, R, Weinberger, P, Golusiński, W, Golusiński, P, Ibbs, M, Korski, K, Mackiewicz, A, Suchorska, W, Szybiak, B, Curley, E, Beard, C, Mitchell, C, Sandusky, G, Ahn, J, Khan, Z, Irish, J, Waldron, J, William, WN, Egea, S, Gomez-Fernandez, C, Herbert, L, Bradford, CR, Chepeha, DB, Haddad, AS, Jones, TR, Komarck, CM, Malakh, M, Moyer, JS, Nguyen, A, Peterson, LA, Prince, ME, Rozek, LS, Taylor, EG, Walline, HM, Wolf, GT, Boice, L, Chera, BS, Funkhouser, WK, Gulley, ML, Hackman, TG, Hayward, MC, Huang, M, Rathmell, WK, Salazar, AH, Shockley, WW, Shores, CG, Thorne, L, Weissler, MC, Wrenn, S, Zanation, AM, Brown, BT, Pham, M & The Cancer Genome Atlas Network 2015, 'Comprehensive genomic characterization of head and neck squamous cell carcinomas' Nature, vol 517, no. 7536, pp. 576-582. DOI: 10.1038/nature14129
Lawrence MS, Sougnez C, Lichtenstein L, Cibulskis K, Lander E, Gabriel SB et al. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015 Jan 29;517(7536):576-582. Available from, DOI: 10.1038/nature14129
Lawrence, Michael S. ; Sougnez, Carrie ; Lichtenstein, Lee ; Cibulskis, Kristian ; Lander, Eric ; Gabriel, Stacey B. ; Getz, Gad ; Ally, Adrian ; Balasundaram, Miruna ; Birol, Inanc ; Bowlby, Reanne ; Brooks, Denise ; Butterfield, Yaron S.N. ; Carlsen, Rebecca ; Cheng, Dean ; Chu, Andy ; Dhalla, Noreen ; Guin, Ranabir ; Holt, Robert A. ; Jones, Steven J.M. ; Lee, Darlene ; Li, Haiyan I. ; Marra, Marco A. ; Mayo, Michael ; Moore, Richard A. ; Mungall, Andrew J. ; Robertson, A. Gordon ; Schein, Jacqueline E. ; Sipahimalani, Payal ; Tam, Angela ; Thiessen, Nina ; Wong, Tina ; Protopopov, Alexei ; Santoso, Netty ; Lee, Semin ; Parfenov, Michael ; Zhang, Jianhua ; Mahadeshwar, Harshad S. ; Tang, Jiabin ; Ren, Xiaojia ; Seth, Sahil ; Haseley, Psalm ; Zeng, Dong ; Yang, Lixing ; Xu, Andrew W. ; Song, Xingzhi ; Pantazi, Angeliki ; Bristow, Christopher A. ; Hadjipanayis, Angela ; Seidman, Jonathan ; Chin, Lynda ; Park, Peter J. ; Kucherlapati, Raju ; Akbani, Rehan ; Casasent, Tod ; Liu, Wenbin ; Lu, Yiling ; Mills, Gordon ; Motter, Thomas ; Weinstein, John ; Diao, Lixia ; Wang, Jing ; Hong Fan, You ; Liu, Jinze ; Wang, Kai ; Auman, J. Todd ; Balu, Saianand ; Bodenheimer, Thomas ; Buda, Elizabeth ; Hayes, D. Neil ; Hoadley, Katherine A. ; Hoyle, Alan P. ; Jefferys, Stuart R. ; Jones, Corbin D. ; Kimes, Patrick K. ; Liu, Yufeng ; Marron, J. S. ; Meng, Shaowu ; Mieczkowski, Piotr A. ; Mose, Lisle E. ; Parker, Joel S. ; Perou, Charles M. ; Prins, Jan F. ; Roach, Jeffrey ; Shi, Yan ; Simons, Janae V. ; Singh, Darshan ; Soloway, Matthew G. ; Tan, Donghui ; Veluvolu, Umadevi ; Walter, Vonn ; Waring, Scot ; Wilkerson, Matthew D. ; Wu, Junyuan ; Zhao, Ni ; Cherniack, Andrew D. ; Hammerman, Peter S. ; Tward, Aaron D. ; Pedamallu, Chandra Sekhar ; Saksena, Gordon ; Jung, Joonil ; Ojesina, Akinyemi I. ; Carter, Scott L. ; Zack, Travis I. ; Schumacher, Steven E. ; Beroukhim, Rameen ; Freeman, Samuel S. ; Meyerson, Matthew ; Cho, Juok ; Noble, Michael S. ; DiCara, Daniel ; Zhang, Hailei ; Heiman, David I. ; Gehlenborg, Nils ; Voet, Doug ; Lin, Pei ; Frazer, Scott ; Stojanov, Petar ; Liu, Yingchun ; Zou, Lihua ; Kim, Jaegil ; Muzny, Donna ; Doddapaneni, Harsha Vardhan ; Kovar, Christie ; Reid, Jeff ; Morton, Donna ; Han, Yi ; Hale, Walker ; Chao, Hsu ; Chang, Kyle ; Drummond, Jennifer A. ; Gibbs, Richard A. ; Kakkar, Nipun ; Wheeler, David ; Xi, Liu ; Ciriello, Giovanni ; Ladanyi, Marc ; Lee, William ; Ramirez, Ricardo ; Sander, Chris ; Shen, Ronglai ; Sinha, Rileen ; Weinhold, Nils ; Taylor, Barry S. ; Aksoy, B. Arman ; Dresdner, Gideon ; Gao, Jianjiong ; Gross, Benjamin ; Jacobsen, Anders ; Reva, Boris ; Schultz, Nikolaus ; Sumer, S. Onur ; Sun, Yichao ; Chan, Timothy A. ; Morris, Luc G. ; Stuart, Joshua ; Benz, Stephen ; Ng, Sam ; Benz, Christopher ; Yau, Christina ; Baylin, Stephen B. ; Cope, Leslie ; Danilova, Ludmila ; Herman, James G. ; Bootwalla, Moiz ; Maglinte, Dennis T. ; Laird, Peter W. ; Triche, Timothy ; Weisenberger, Daniel J. ; Van Den Berg, David J. ; Agrawal, Nishant ; Bishop, Justin ; Boutros, Paul C. ; Bruce, Jeff P. ; Byers, Lauren Averett ; Califano, Joseph ; Carey, Thomas E. ; Chen, Zhong ; Cheng, Hui ; Chiosea, Simion I. ; Cohen, Ezra ; Diergaarde, Brenda ; Egloff, Ann Marie ; El-Naggar, Adel K. ; Ferris, Robert L. ; Frederick, Mitchell J. ; Grandis, Jennifer R. ; Guo, Yan ; Haddad, Robert I. ; Harris, Thomas ; Hui, Angela B.Y. ; Lee, J. Jack ; Lippman, Scott M. ; Liu, Fei Fei ; McHugh, Jonathan B. ; Myers, Jeff ; Ng, Patrick Kwok Shing ; Perez-Ordonez, Bayardo ; Pickering, Curtis R. ; Prystowsky, Michael ; Romkes, Marjorie ; Saleh, Anthony D. ; Sartor, Maureen A. ; Seethala, Raja ; Seiwert, Tanguy Y. ; Si, Han ; Van Waes, Carter ; Waggott, Daryl M. ; Wiznerowicz, Maciej ; Yarbrough, Wendell G. ; Zhang, Jiexin ; Zuo, Zhixiang ; Burnett, Ken ; Crain, Daniel ; Gardner, Johanna ; Lau, Kevin ; Mallery, David ; Morris, Scott ; Paulauskis, Joseph ; Penny, Robert ; Shelton, Candace ; Shelton, Troy ; Sherman, Mark ; Yena, Peggy ; Black, Aaron D. ; Bowen, Jay ; Frick, Jessica ; Gastier-Foster, Julie M. ; Harper, Hollie A. ; Leraas, Kristen ; Lichtenberg, Tara M. ; Ramirez, Nilsa C. ; Wise, Lisa ; Zmuda, Erik ; Baboud, Julien ; Jensen, Mark A. ; Kahn, Ari B. ; Pihl, Todd D. ; Pot, David A. ; Srinivasan, Deepak ; Walton, Jessica S. ; Wan, Yunhu ; Burton, Robert A. ; Davidsen, Tanja ; Demchok, John A. ; Eley, Greg ; Ferguson, Martin L. ; Mills Shaw, Kenna R. ; Ozenberger, Bradley A. ; Sheth, Margi ; Sofia, Heidi J. ; Tarnuzzer, Roy ; Wang, Zhining ; Yang, Liming ; Zenklusen, Jean Claude ; Saller, Charles ; Tarvin, Katherine ; Chen, Chu ; Bollag, Roni ; Weinberger, Paul ; Golusiński, Wojciech ; Golusiński, Paweł ; Ibbs, Matthew ; Korski, Konstanty ; Mackiewicz, Andrzej ; Suchorska, Wiktoria ; Szybiak, Bartosz ; Curley, Erin ; Beard, Christina ; Mitchell, Colleen ; Sandusky, George ; Ahn, Julie ; Khan, Zubair ; Irish, Jonathan ; Waldron, John ; William, William N. ; Egea, Sophie ; Gomez-Fernandez, Carmen ; Herbert, Lynn ; Bradford, Carol R. ; Chepeha, Douglas B. ; Haddad, Andrea S. ; Jones, Tamara R. ; Komarck, Christine M. ; Malakh, Mayya ; Moyer, Jeffrey S. ; Nguyen, Ariane ; Peterson, Lisa A. ; Prince, Mark E. ; Rozek, Laura S. ; Taylor, Evan G. ; Walline, Heather M. ; Wolf, Gregory T. ; Boice, Lori ; Chera, Bhishamjit S. ; Funkhouser, William K. ; Gulley, Margaret L. ; Hackman, Trevor G. ; Hayward, Michele C. ; Huang, Mei ; Rathmell, W. Kimryn ; Salazar, Ashley H. ; Shockley, William W. ; Shores, Carol G. ; Thorne, Leigh ; Weissler, Mark C. ; Wrenn, Sylvia ; Zanation, Adam M. ; Brown, Brandee T. ; Pham, Michelle ; The Cancer Genome Atlas Network. / Comprehensive genomic characterization of head and neck squamous cell carcinomas. In: Nature. 2015 ; Vol. 517, No. 7536. pp. 576-582
@article{d0cccd967cce475298be5ce28ab499bb,
title = "Comprehensive genomic characterization of head and neck squamous cell carcinomas",
abstract = "The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.",
author = "Lawrence, {Michael S.} and Carrie Sougnez and Lee Lichtenstein and Kristian Cibulskis and Eric Lander and Gabriel, {Stacey B.} and Gad Getz and Adrian Ally and Miruna Balasundaram and Inanc Birol and Reanne Bowlby and Denise Brooks and Butterfield, {Yaron S.N.} and Rebecca Carlsen and Dean Cheng and Andy Chu and Noreen Dhalla and Ranabir Guin and Holt, {Robert A.} and Jones, {Steven J.M.} and Darlene Lee and Li, {Haiyan I.} and Marra, {Marco A.} and Michael Mayo and Moore, {Richard A.} and Mungall, {Andrew J.} and Robertson, {A. Gordon} and Schein, {Jacqueline E.} and Payal Sipahimalani and Angela Tam and Nina Thiessen and Tina Wong and Alexei Protopopov and Netty Santoso and Semin Lee and Michael Parfenov and Jianhua Zhang and Mahadeshwar, {Harshad S.} and Jiabin Tang and Xiaojia Ren and Sahil Seth and Psalm Haseley and Dong Zeng and Lixing Yang and Xu, {Andrew W.} and Xingzhi Song and Angeliki Pantazi and Bristow, {Christopher A.} and Angela Hadjipanayis and Jonathan Seidman and Lynda Chin and Park, {Peter J.} and Raju Kucherlapati and Rehan Akbani and Tod Casasent and Wenbin Liu and Yiling Lu and Gordon Mills and Thomas Motter and John Weinstein and Lixia Diao and Jing Wang and {Hong Fan}, You and Jinze Liu and Kai Wang and Auman, {J. Todd} and Saianand Balu and Thomas Bodenheimer and Elizabeth Buda and Hayes, {D. Neil} and Hoadley, {Katherine A.} and Hoyle, {Alan P.} and Jefferys, {Stuart R.} and Jones, {Corbin D.} and Kimes, {Patrick K.} and Yufeng Liu and Marron, {J. S.} and Shaowu Meng and Mieczkowski, {Piotr A.} and Mose, {Lisle E.} and Parker, {Joel S.} and Perou, {Charles M.} and Prins, {Jan F.} and Jeffrey Roach and Yan Shi and Simons, {Janae V.} and Darshan Singh and Soloway, {Matthew G.} and Donghui Tan and Umadevi Veluvolu and Vonn Walter and Scot Waring and Wilkerson, {Matthew D.} and Junyuan Wu and Ni Zhao and Cherniack, {Andrew D.} and Hammerman, {Peter S.} and Tward, {Aaron D.} and Pedamallu, {Chandra Sekhar} and Gordon Saksena and Joonil Jung and Ojesina, {Akinyemi I.} and Carter, {Scott L.} and Zack, {Travis I.} and Schumacher, {Steven E.} and Rameen Beroukhim and Freeman, {Samuel S.} and Matthew Meyerson and Juok Cho and Noble, {Michael S.} and Daniel DiCara and Hailei Zhang and Heiman, {David I.} and Nils Gehlenborg and Doug Voet and Pei Lin and Scott Frazer and Petar Stojanov and Yingchun Liu and Lihua Zou and Jaegil Kim and Donna Muzny and Doddapaneni, {Harsha Vardhan} and Christie Kovar and Jeff Reid and Donna Morton and Yi Han and Walker Hale and Hsu Chao and Kyle Chang and Drummond, {Jennifer A.} and Gibbs, {Richard A.} and Nipun Kakkar and David Wheeler and Liu Xi and Giovanni Ciriello and Marc Ladanyi and William Lee and Ricardo Ramirez and Chris Sander and Ronglai Shen and Rileen Sinha and Nils Weinhold and Taylor, {Barry S.} and Aksoy, {B. Arman} and Gideon Dresdner and Jianjiong Gao and Benjamin Gross and Anders Jacobsen and Boris Reva and Nikolaus Schultz and Sumer, {S. Onur} and Yichao Sun and Chan, {Timothy A.} and Morris, {Luc G.} and Joshua Stuart and Stephen Benz and Sam Ng and Christopher Benz and Christina Yau and Baylin, {Stephen B.} and Leslie Cope and Ludmila Danilova and Herman, {James G.} and Moiz Bootwalla and Maglinte, {Dennis T.} and Laird, {Peter W.} and Timothy Triche and Weisenberger, {Daniel J.} and {Van Den Berg}, {David J.} and Nishant Agrawal and Justin Bishop and Boutros, {Paul C.} and Bruce, {Jeff P.} and Byers, {Lauren Averett} and Joseph Califano and Carey, {Thomas E.} and Zhong Chen and Hui Cheng and Chiosea, {Simion I.} and Ezra Cohen and Brenda Diergaarde and Egloff, {Ann Marie} and El-Naggar, {Adel K.} and Ferris, {Robert L.} and Frederick, {Mitchell J.} and Grandis, {Jennifer R.} and Yan Guo and Haddad, {Robert I.} and Thomas Harris and Hui, {Angela B.Y.} and Lee, {J. Jack} and Lippman, {Scott M.} and Liu, {Fei Fei} and McHugh, {Jonathan B.} and Jeff Myers and Ng, {Patrick Kwok Shing} and Bayardo Perez-Ordonez and Pickering, {Curtis R.} and Michael Prystowsky and Marjorie Romkes and Saleh, {Anthony D.} and Sartor, {Maureen A.} and Raja Seethala and Seiwert, {Tanguy Y.} and Han Si and {Van Waes}, Carter and Waggott, {Daryl M.} and Maciej Wiznerowicz and Yarbrough, {Wendell G.} and Jiexin Zhang and Zhixiang Zuo and Ken Burnett and Daniel Crain and Johanna Gardner and Kevin Lau and David Mallery and Scott Morris and Joseph Paulauskis and Robert Penny and Candace Shelton and Troy Shelton and Mark Sherman and Peggy Yena and Black, {Aaron D.} and Jay Bowen and Jessica Frick and Gastier-Foster, {Julie M.} and Harper, {Hollie A.} and Kristen Leraas and Lichtenberg, {Tara M.} and Ramirez, {Nilsa C.} and Lisa Wise and Erik Zmuda and Julien Baboud and Jensen, {Mark A.} and Kahn, {Ari B.} and Pihl, {Todd D.} and Pot, {David A.} and Deepak Srinivasan and Walton, {Jessica S.} and Yunhu Wan and Burton, {Robert A.} and Tanja Davidsen and Demchok, {John A.} and Greg Eley and Ferguson, {Martin L.} and {Mills Shaw}, {Kenna R.} and Ozenberger, {Bradley A.} and Margi Sheth and Sofia, {Heidi J.} and Roy Tarnuzzer and Zhining Wang and Liming Yang and Zenklusen, {Jean Claude} and Charles Saller and Katherine Tarvin and Chu Chen and Roni Bollag and Paul Weinberger and Wojciech Golusiński and Paweł Golusiński and Matthew Ibbs and Konstanty Korski and Andrzej Mackiewicz and Wiktoria Suchorska and Bartosz Szybiak and Erin Curley and Christina Beard and Colleen Mitchell and George Sandusky and Julie Ahn and Zubair Khan and Jonathan Irish and John Waldron and William, {William N.} and Sophie Egea and Carmen Gomez-Fernandez and Lynn Herbert and Bradford, {Carol R.} and Chepeha, {Douglas B.} and Haddad, {Andrea S.} and Jones, {Tamara R.} and Komarck, {Christine M.} and Mayya Malakh and Moyer, {Jeffrey S.} and Ariane Nguyen and Peterson, {Lisa A.} and Prince, {Mark E.} and Rozek, {Laura S.} and Taylor, {Evan G.} and Walline, {Heather M.} and Wolf, {Gregory T.} and Lori Boice and Chera, {Bhishamjit S.} and Funkhouser, {William K.} and Gulley, {Margaret L.} and Hackman, {Trevor G.} and Hayward, {Michele C.} and Mei Huang and Rathmell, {W. Kimryn} and Salazar, {Ashley H.} and Shockley, {William W.} and Shores, {Carol G.} and Leigh Thorne and Weissler, {Mark C.} and Sylvia Wrenn and Zanation, {Adam M.} and Brown, {Brandee T.} and Michelle Pham and {The Cancer Genome Atlas Network}",
year = "2015",
month = "1",
doi = "10.1038/nature14129",
volume = "517",
pages = "576--582",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7536",

}

TY - JOUR

T1 - Comprehensive genomic characterization of head and neck squamous cell carcinomas

AU - Lawrence,Michael S.

AU - Sougnez,Carrie

AU - Lichtenstein,Lee

AU - Cibulskis,Kristian

AU - Lander,Eric

AU - Gabriel,Stacey B.

AU - Getz,Gad

AU - Ally,Adrian

AU - Balasundaram,Miruna

AU - Birol,Inanc

AU - Bowlby,Reanne

AU - Brooks,Denise

AU - Butterfield,Yaron S.N.

AU - Carlsen,Rebecca

AU - Cheng,Dean

AU - Chu,Andy

AU - Dhalla,Noreen

AU - Guin,Ranabir

AU - Holt,Robert A.

AU - Jones,Steven J.M.

AU - Lee,Darlene

AU - Li,Haiyan I.

AU - Marra,Marco A.

AU - Mayo,Michael

AU - Moore,Richard A.

AU - Mungall,Andrew J.

AU - Robertson,A. Gordon

AU - Schein,Jacqueline E.

AU - Sipahimalani,Payal

AU - Tam,Angela

AU - Thiessen,Nina

AU - Wong,Tina

AU - Protopopov,Alexei

AU - Santoso,Netty

AU - Lee,Semin

AU - Parfenov,Michael

AU - Zhang,Jianhua

AU - Mahadeshwar,Harshad S.

AU - Tang,Jiabin

AU - Ren,Xiaojia

AU - Seth,Sahil

AU - Haseley,Psalm

AU - Zeng,Dong

AU - Yang,Lixing

AU - Xu,Andrew W.

AU - Song,Xingzhi

AU - Pantazi,Angeliki

AU - Bristow,Christopher A.

AU - Hadjipanayis,Angela

AU - Seidman,Jonathan

AU - Chin,Lynda

AU - Park,Peter J.

AU - Kucherlapati,Raju

AU - Akbani,Rehan

AU - Casasent,Tod

AU - Liu,Wenbin

AU - Lu,Yiling

AU - Mills,Gordon

AU - Motter,Thomas

AU - Weinstein,John

AU - Diao,Lixia

AU - Wang,Jing

AU - Hong Fan,You

AU - Liu,Jinze

AU - Wang,Kai

AU - Auman,J. Todd

AU - Balu,Saianand

AU - Bodenheimer,Thomas

AU - Buda,Elizabeth

AU - Hayes,D. Neil

AU - Hoadley,Katherine A.

AU - Hoyle,Alan P.

AU - Jefferys,Stuart R.

AU - Jones,Corbin D.

AU - Kimes,Patrick K.

AU - Liu,Yufeng

AU - Marron,J. S.

AU - Meng,Shaowu

AU - Mieczkowski,Piotr A.

AU - Mose,Lisle E.

AU - Parker,Joel S.

AU - Perou,Charles M.

AU - Prins,Jan F.

AU - Roach,Jeffrey

AU - Shi,Yan

AU - Simons,Janae V.

AU - Singh,Darshan

AU - Soloway,Matthew G.

AU - Tan,Donghui

AU - Veluvolu,Umadevi

AU - Walter,Vonn

AU - Waring,Scot

AU - Wilkerson,Matthew D.

AU - Wu,Junyuan

AU - Zhao,Ni

AU - Cherniack,Andrew D.

AU - Hammerman,Peter S.

AU - Tward,Aaron D.

AU - Pedamallu,Chandra Sekhar

AU - Saksena,Gordon

AU - Jung,Joonil

AU - Ojesina,Akinyemi I.

AU - Carter,Scott L.

AU - Zack,Travis I.

AU - Schumacher,Steven E.

AU - Beroukhim,Rameen

AU - Freeman,Samuel S.

AU - Meyerson,Matthew

AU - Cho,Juok

AU - Noble,Michael S.

AU - DiCara,Daniel

AU - Zhang,Hailei

AU - Heiman,David I.

AU - Gehlenborg,Nils

AU - Voet,Doug

AU - Lin,Pei

AU - Frazer,Scott

AU - Stojanov,Petar

AU - Liu,Yingchun

AU - Zou,Lihua

AU - Kim,Jaegil

AU - Muzny,Donna

AU - Doddapaneni,Harsha Vardhan

AU - Kovar,Christie

AU - Reid,Jeff

AU - Morton,Donna

AU - Han,Yi

AU - Hale,Walker

AU - Chao,Hsu

AU - Chang,Kyle

AU - Drummond,Jennifer A.

AU - Gibbs,Richard A.

AU - Kakkar,Nipun

AU - Wheeler,David

AU - Xi,Liu

AU - Ciriello,Giovanni

AU - Ladanyi,Marc

AU - Lee,William

AU - Ramirez,Ricardo

AU - Sander,Chris

AU - Shen,Ronglai

AU - Sinha,Rileen

AU - Weinhold,Nils

AU - Taylor,Barry S.

AU - Aksoy,B. Arman

AU - Dresdner,Gideon

AU - Gao,Jianjiong

AU - Gross,Benjamin

AU - Jacobsen,Anders

AU - Reva,Boris

AU - Schultz,Nikolaus

AU - Sumer,S. Onur

AU - Sun,Yichao

AU - Chan,Timothy A.

AU - Morris,Luc G.

AU - Stuart,Joshua

AU - Benz,Stephen

AU - Ng,Sam

AU - Benz,Christopher

AU - Yau,Christina

AU - Baylin,Stephen B.

AU - Cope,Leslie

AU - Danilova,Ludmila

AU - Herman,James G.

AU - Bootwalla,Moiz

AU - Maglinte,Dennis T.

AU - Laird,Peter W.

AU - Triche,Timothy

AU - Weisenberger,Daniel J.

AU - Van Den Berg,David J.

AU - Agrawal,Nishant

AU - Bishop,Justin

AU - Boutros,Paul C.

AU - Bruce,Jeff P.

AU - Byers,Lauren Averett

AU - Califano,Joseph

AU - Carey,Thomas E.

AU - Chen,Zhong

AU - Cheng,Hui

AU - Chiosea,Simion I.

AU - Cohen,Ezra

AU - Diergaarde,Brenda

AU - Egloff,Ann Marie

AU - El-Naggar,Adel K.

AU - Ferris,Robert L.

AU - Frederick,Mitchell J.

AU - Grandis,Jennifer R.

AU - Guo,Yan

AU - Haddad,Robert I.

AU - Harris,Thomas

AU - Hui,Angela B.Y.

AU - Lee,J. Jack

AU - Lippman,Scott M.

AU - Liu,Fei Fei

AU - McHugh,Jonathan B.

AU - Myers,Jeff

AU - Ng,Patrick Kwok Shing

AU - Perez-Ordonez,Bayardo

AU - Pickering,Curtis R.

AU - Prystowsky,Michael

AU - Romkes,Marjorie

AU - Saleh,Anthony D.

AU - Sartor,Maureen A.

AU - Seethala,Raja

AU - Seiwert,Tanguy Y.

AU - Si,Han

AU - Van Waes,Carter

AU - Waggott,Daryl M.

AU - Wiznerowicz,Maciej

AU - Yarbrough,Wendell G.

AU - Zhang,Jiexin

AU - Zuo,Zhixiang

AU - Burnett,Ken

AU - Crain,Daniel

AU - Gardner,Johanna

AU - Lau,Kevin

AU - Mallery,David

AU - Morris,Scott

AU - Paulauskis,Joseph

AU - Penny,Robert

AU - Shelton,Candace

AU - Shelton,Troy

AU - Sherman,Mark

AU - Yena,Peggy

AU - Black,Aaron D.

AU - Bowen,Jay

AU - Frick,Jessica

AU - Gastier-Foster,Julie M.

AU - Harper,Hollie A.

AU - Leraas,Kristen

AU - Lichtenberg,Tara M.

AU - Ramirez,Nilsa C.

AU - Wise,Lisa

AU - Zmuda,Erik

AU - Baboud,Julien

AU - Jensen,Mark A.

AU - Kahn,Ari B.

AU - Pihl,Todd D.

AU - Pot,David A.

AU - Srinivasan,Deepak

AU - Walton,Jessica S.

AU - Wan,Yunhu

AU - Burton,Robert A.

AU - Davidsen,Tanja

AU - Demchok,John A.

AU - Eley,Greg

AU - Ferguson,Martin L.

AU - Mills Shaw,Kenna R.

AU - Ozenberger,Bradley A.

AU - Sheth,Margi

AU - Sofia,Heidi J.

AU - Tarnuzzer,Roy

AU - Wang,Zhining

AU - Yang,Liming

AU - Zenklusen,Jean Claude

AU - Saller,Charles

AU - Tarvin,Katherine

AU - Chen,Chu

AU - Bollag,Roni

AU - Weinberger,Paul

AU - Golusiński,Wojciech

AU - Golusiński,Paweł

AU - Ibbs,Matthew

AU - Korski,Konstanty

AU - Mackiewicz,Andrzej

AU - Suchorska,Wiktoria

AU - Szybiak,Bartosz

AU - Curley,Erin

AU - Beard,Christina

AU - Mitchell,Colleen

AU - Sandusky,George

AU - Ahn,Julie

AU - Khan,Zubair

AU - Irish,Jonathan

AU - Waldron,John

AU - William,William N.

AU - Egea,Sophie

AU - Gomez-Fernandez,Carmen

AU - Herbert,Lynn

AU - Bradford,Carol R.

AU - Chepeha,Douglas B.

AU - Haddad,Andrea S.

AU - Jones,Tamara R.

AU - Komarck,Christine M.

AU - Malakh,Mayya

AU - Moyer,Jeffrey S.

AU - Nguyen,Ariane

AU - Peterson,Lisa A.

AU - Prince,Mark E.

AU - Rozek,Laura S.

AU - Taylor,Evan G.

AU - Walline,Heather M.

AU - Wolf,Gregory T.

AU - Boice,Lori

AU - Chera,Bhishamjit S.

AU - Funkhouser,William K.

AU - Gulley,Margaret L.

AU - Hackman,Trevor G.

AU - Hayward,Michele C.

AU - Huang,Mei

AU - Rathmell,W. Kimryn

AU - Salazar,Ashley H.

AU - Shockley,William W.

AU - Shores,Carol G.

AU - Thorne,Leigh

AU - Weissler,Mark C.

AU - Wrenn,Sylvia

AU - Zanation,Adam M.

AU - Brown,Brandee T.

AU - Pham,Michelle

AU - The Cancer Genome Atlas Network

PY - 2015/1/29

Y1 - 2015/1/29

N2 - The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.

AB - The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.

UR - http://www.scopus.com/inward/record.url?scp=84923197605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923197605&partnerID=8YFLogxK

U2 - 10.1038/nature14129

DO - 10.1038/nature14129

M3 - Article

VL - 517

SP - 576

EP - 582

JO - Nature

T2 - Nature

JF - Nature

SN - 0028-0836

IS - 7536

ER -