Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers

Dhiren R. Thakker (Inventor), Peter D. Ward (Inventor)

Research output: ResearchPatent

Abstract

Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.
LanguageEnglish
Patent number7713949
IPCA01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101)
StatePublished - 1800

Fingerprint

permeability
method
inhibitor
drug

Keywords

    Cite this

    Thakker, D. R., & Ward, P. D. (1800). IPC No. A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101). Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers (Patent No. 7713949.)

    Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers. / Thakker, Dhiren R. (Inventor); Ward, Peter D. (Inventor).

    IPC No.: A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101). Patent No.: 7713949.

    Research output: ResearchPatent

    Thakker, DR & Ward, PD 1800, Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers, Patent No. 7713949, IPC No. A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101).
    Thakker DR, Ward PD, inventors. Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers. A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101). 1800
    Thakker, Dhiren R. (Inventor) ; Ward, Peter D. (Inventor). / Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers. IPC No.: A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101). Patent No.: 7713949.
    @misc{e89e98d4fabc4e14a35e8406ad9bb4d4,
    title = "Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers",
    abstract = "Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.",
    keywords = "514/75,76,642,946",
    author = "Thakker, {Dhiren R.} and Ward, {Peter D.}",
    note = "Status: published applicationnumber: 09/974,519 usclass: 514/75 ; 514/642; 514/76; 514/946 applicationnumber: 09/974,519; 7713949; A01N 57/00 (20060101); A01K 31/14 (20060101); A01N 57/26 (20060101); A61K 31/685 (20060101); A61K 31/66 (20060101); A01N 33/12 (20060101)",
    year = "1800",
    type = "Patent",

    }

    TY - PAT

    T1 - Compositions and Methods for Enhancing Paracellular Permeability across Epithelial and Endothelial Barriers

    AU - Thakker,Dhiren R.

    AU - Ward,Peter D.

    N1 - Status: published applicationnumber: 09/974,519 usclass: 514/75 ; 514/642; 514/76; 514/946 applicationnumber: 09/974,519

    PY - 1800

    Y1 - 1800

    N2 - Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.

    AB - Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.

    KW - 514/75,76,642,946

    M3 - Patent

    M1 - 7713949

    ER -