Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Jae Lee Seung, Rachel J. Steiner, Yu Yang, J. Short Sarah, C. Neale Michael, Andreas Styner Martin, Zhu Hongtu, H. Gilmore John

Research output: Contribution to journalArticle

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Abstract

Previous studies indicate that the microstructure of individual white matter (WM) tracts is related to cognitive function. More recent studies indicate that the microstructure of individual tracts is highly correlated and that a property common across WM is related to overall cognitive function in adults. However, little is known about whether these common WM properties exist in early childhood development or how they are related to cognitive development. In this study, we used diffusion tensor imaging (DTI) to investigate common underlying factors in 12 fiber tracts, their relationship with cognitive function, and their heritability in a longitudinal sample of healthy children at birth (n = 535), 1 y (n = 322), and 2 y (n = 244) of age. Our data show that, in neonates, there is a highly significant correlation between major WM tracts that decreases from birth to 2 y of age. Over the same period, the factor structure increases in complexity, from one factor at birth to three factors at age 2 y, which explain 50% of variance. The identified common factors of DTI metrics in each age group are significantly correlated with general cognitive scores and predict cognitive ability in later childhood. These factors are moderately heritable. These findings illustrate the anatomical differentiation of WM fiber from birth to 2 y of age that correlate with cognitive development. Our results also suggest that the common factor approach is an informative way to study WM development and its relationship with cognition and is a useful approach for future imaging genetic studies.

LanguageEnglish (US)
Pages148-153
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number1
DOIs
StatePublished - Jan 3 2017

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Cognition
Parturition
Diffusion Tensor Imaging
Aptitude
Age Factors
White Matter
Age Groups
Newborn Infant

Keywords

  • Cognition
  • DTI
  • Factoranalysis
  • Heritability
  • Whitematter

ASJC Scopus subject areas

  • General

Cite this

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y. / Seung, Jae Lee; Steiner, Rachel J.; Yang, Yu; Sarah, J. Short; Michael, C. Neale; Martin, Andreas Styner; Hongtu, Zhu; John, H. Gilmore.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 1, 03.01.2017, p. 148-153.

Research output: Contribution to journalArticle

Seung, Jae Lee ; Steiner, Rachel J. ; Yang, Yu ; Sarah, J. Short ; Michael, C. Neale ; Martin, Andreas Styner ; Hongtu, Zhu ; John, H. Gilmore. / Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 1. pp. 148-153.
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