Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study

Yash R. Patel, Taraka V. Gadiraju, R. Curtis Ellison, Steven C. Hunt, John Jeffrey Carr, Gerardo Heiss, Donna K. Arnett, James S. Pankow, J. Michael Gaziano, Luc Djoussé

Research output: Research - peer-reviewArticle

Abstract

Background & aims While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. Methods In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. Results Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57–1.49), 1.34 (0.86–2.08), 1.30 (0.84–2.02), and 0.99 (0.60–1.64) for coffee consumption of almost never, <1/day, 1/day, 2–3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.

LanguageEnglish (US)
Pages18-21
Number of pages4
JournalClinical Nutrition ESPEN
Volume17
DOIs
StatePublished - Feb 1 2017

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National Heart, Lung, and Blood Institute (U.S.)
Coffee
Atherosclerotic Plaques
Coronary Vessels
Calcium
Energy Intake
Coronary Disease
Meta-Analysis
Cardiovascular Diseases
Smoking
Tomography
Alcohols
Prospective Studies
Exercise
Food
Mortality
Surveys and Questionnaires

Keywords

  • Atherosclerosis
  • Coffee consumption
  • Coronary artery calcium
  • Epidemiology
  • Nutrition

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Patel, Y. R., Gadiraju, T. V., Ellison, R. C., Hunt, S. C., Carr, J. J., Heiss, G., ... Djoussé, L. (2017). Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study. Clinical Nutrition ESPEN, 17, 18-21. DOI: 10.1016/j.clnesp.2016.12.003

Coffee consumption and calcified atherosclerotic plaques in the coronary arteries : The NHLBI Family Heart Study. / Patel, Yash R.; Gadiraju, Taraka V.; Ellison, R. Curtis; Hunt, Steven C.; Carr, John Jeffrey; Heiss, Gerardo; Arnett, Donna K.; Pankow, James S.; Gaziano, J. Michael; Djoussé, Luc.

In: Clinical Nutrition ESPEN, Vol. 17, 01.02.2017, p. 18-21.

Research output: Research - peer-reviewArticle

Patel, YR, Gadiraju, TV, Ellison, RC, Hunt, SC, Carr, JJ, Heiss, G, Arnett, DK, Pankow, JS, Gaziano, JM & Djoussé, L 2017, 'Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study' Clinical Nutrition ESPEN, vol 17, pp. 18-21. DOI: 10.1016/j.clnesp.2016.12.003
Patel, Yash R. ; Gadiraju, Taraka V. ; Ellison, R. Curtis ; Hunt, Steven C. ; Carr, John Jeffrey ; Heiss, Gerardo ; Arnett, Donna K. ; Pankow, James S. ; Gaziano, J. Michael ; Djoussé, Luc. / Coffee consumption and calcified atherosclerotic plaques in the coronary arteries : The NHLBI Family Heart Study. In: Clinical Nutrition ESPEN. 2017 ; Vol. 17. pp. 18-21
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