Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection

Daniella M. Cordero, Sheri L. Towe, Nan kuei Chen, Kevin R. Robertson, David J. Madden, Scott A. Huettel, Christina S. Meade

Research output: Contribution to journalArticle

  • 4 Citations

Abstract

This study investigated the association of HIV infection and cocaine dependence with cerebral white matter integrity using diffusion tensor imaging (DTI). One hundred thirty-five participants stratified by HIV and cocaine status (26 HIV+/COC+, 37 HIV+/COC−, 37 HIV−/COC+, and 35 HIV−/COC−) completed a comprehensive substance abuse assessment, neuropsychological testing, and MRI with DTI. Among HIV+ participants, all were receiving HIV care and 46% had an AIDS diagnosis. All COC+ participants were current users and met criteria for cocaine use disorder. We used tract-based spatial statistics (TBSS) to assess the relation of HIV and cocaine to fractional anisotropy (FA) and mean diffusivity (MD). In whole-brain analyses, HIV+ participants had significantly reduced FA and increased MD compared to HIV− participants. The relation of HIV and FA was widespread throughout the brain, whereas the HIV-related MD effects were restricted to the corpus callosum and thalamus. There were no significant cocaine or HIV-by-cocaine effects. These DTI metrics correlated significantly with duration of HIV disease, nadir CD4+ cell count, and AIDS diagnosis, as well as some measures of neuropsychological functioning. These results suggest that HIV is related to white matter integrity throughout the brain, and that HIV-related effects are more pronounced with increasing duration of infection and greater immune compromise. We found no evidence for independent effects of cocaine dependence on white matter integrity, and cocaine dependence did not appear to exacerbate the effects of HIV.

LanguageEnglish (US)
Pages441-450
Number of pages10
JournalJournal of NeuroVirology
Volume23
Issue number3
DOIs
StatePublished - Jun 1 2017

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Cocaine-Related Disorders
HIV Infections
HIV
Cocaine
Diffusion Tensor Imaging
Anisotropy
White Matter
Brain
Acquired Immunodeficiency Syndrome
Corpus Callosum

Keywords

  • Cocaine
  • Diffusion tensor imaging (DTI)
  • HIV infection
  • Magnetic resonance imaging (MRI)
  • Neurocognitive function
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

Cordero, D. M., Towe, S. L., Chen, N. K., Robertson, K. R., Madden, D. J., Huettel, S. A., & Meade, C. S. (2017). Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. Journal of NeuroVirology, 23(3), 441-450. DOI: 10.1007/s13365-017-0512-5

Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. / Cordero, Daniella M.; Towe, Sheri L.; Chen, Nan kuei; Robertson, Kevin R.; Madden, David J.; Huettel, Scott A.; Meade, Christina S.

In: Journal of NeuroVirology, Vol. 23, No. 3, 01.06.2017, p. 441-450.

Research output: Contribution to journalArticle

Cordero, DM, Towe, SL, Chen, NK, Robertson, KR, Madden, DJ, Huettel, SA & Meade, CS 2017, 'Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection' Journal of NeuroVirology, vol 23, no. 3, pp. 441-450. DOI: 10.1007/s13365-017-0512-5
Cordero DM, Towe SL, Chen NK, Robertson KR, Madden DJ, Huettel SA et al. Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. Journal of NeuroVirology. 2017 Jun 1;23(3):441-450. Available from, DOI: 10.1007/s13365-017-0512-5
Cordero, Daniella M. ; Towe, Sheri L. ; Chen, Nan kuei ; Robertson, Kevin R. ; Madden, David J. ; Huettel, Scott A. ; Meade, Christina S./ Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. In: Journal of NeuroVirology. 2017 ; Vol. 23, No. 3. pp. 441-450
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