Cilia and mucociliary clearance

Ximena M. Bustamante-Marin, Lawrence E. Ostrowski

Research output: Contribution to journalArticle

  • 9 Citations

Abstract

Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this review, we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.

LanguageEnglish (US)
Article numbera028241
JournalCold Spring Harbor Perspectives in Biology
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2017

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Mucociliary Clearance
Cilia
Bridge clearances
Health
Pulmonary diseases
Pathogens
Liquids
Dyskinesias
Organelles
Lung Diseases
Chronic Disease
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cilia and mucociliary clearance. / Bustamante-Marin, Ximena M.; Ostrowski, Lawrence E.

In: Cold Spring Harbor Perspectives in Biology, Vol. 9, No. 4, a028241, 01.04.2017.

Research output: Contribution to journalArticle

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