Abstract
Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this review, we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.
| Language | English (US) |
|---|---|
| Article number | a028241 |
| Journal | Cold Spring Harbor Perspectives in Biology |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2017 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cilia and mucociliary clearance. / Bustamante-Marin, Ximena M.; Ostrowski, Lawrence E.
In: Cold Spring Harbor Perspectives in Biology, Vol. 9, No. 4, a028241, 01.04.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cilia and mucociliary clearance
AU - Bustamante-Marin,Ximena M.
AU - Ostrowski,Lawrence E.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this review, we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.
AB - Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this review, we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.
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UR - http://www.scopus.com/inward/citedby.url?scp=85017182500&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a028241
DO - 10.1101/cshperspect.a028241
M3 - Article
VL - 9
JO - Cold Spring Harbor perspectives in biology
T2 - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 4
M1 - a028241
ER -