Chronic norovirus infection in primary immune deficiency disorders: an international case series

M. C. Rolfes, P. Sriaroon, B. J. Dávila Saldaña, C. C. Dvorak, H. Chapdelaine, R. M. Ferdman, K. Chen, S. Jolles, N. C. Patel, Y. J. Kim, Teresa K Tarrant, T. Martelius, M. Seppanen, A. Y. Joshi

Research output: Contribution to journalArticle

Abstract

Objective: Predictive factors associated with clinical outcomes of chronic norovirus infection (CNI) in primary immunodeficiency diseases (PIDD) are lacking. Method: We sought to characterize CNI using a multi-institutional cohort of patients with PIDD and CNI using the Clinical Immunology Society's CIS-PIDD Listserv e-mail group. Results: Thirty-four subjects (21 males and 13 females) were reported from centers across North America, Europe, and Asia. All subjects were receiving high doses (median IgG dose: 1200 mg/kg/month) of supplemental immunoglobulin therapy. Fifty-three percent had a complete absence of B cells (median B-cell count 0; range 0–139 cells/μL). Common Variable Immune Deficiency (CVID) subjects manifested a unique phenotype with B-cell lymphopenia, non O+ blood type, and villous atrophy (logistic regression model, P = 0.01). Five subjects died, all of whom had no evidence of villous atrophy. Conclusion: While Norovirus (NoV) is thought to replicate in B cells, in this PIDD cohort of CNI, B-cell lymphopenia was common, indicating that the presence of B lymphocytes is not essential for CNI.

LanguageEnglish (US)
Pages69-73
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Norovirus
Immune System Diseases
B-Lymphocytes
Infection
Lymphopenia
Atrophy
Chronic Disease
Northern Asia
Logistic Models
Common Variable Immunodeficiency
Passive Immunization
Postal Service
North America
Allergy and Immunology
Cell Count
Immunoglobulin G
Phenotype

Keywords

  • CVID, SCID, transplant, immunocompromised
  • Chronic gastroenteritis
  • Norovirus
  • Primary immunodeficiency diseases PIDD

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Rolfes, M. C., Sriaroon, P., Dávila Saldaña, B. J., Dvorak, C. C., Chapdelaine, H., Ferdman, R. M., ... Joshi, A. Y. (2019). Chronic norovirus infection in primary immune deficiency disorders: an international case series. Diagnostic Microbiology and Infectious Disease, 93(1), 69-73. https://doi.org/10.1016/j.diagmicrobio.2018.08.002

Chronic norovirus infection in primary immune deficiency disorders : an international case series. / Rolfes, M. C.; Sriaroon, P.; Dávila Saldaña, B. J.; Dvorak, C. C.; Chapdelaine, H.; Ferdman, R. M.; Chen, K.; Jolles, S.; Patel, N. C.; Kim, Y. J.; Tarrant, Teresa K; Martelius, T.; Seppanen, M.; Joshi, A. Y.

In: Diagnostic Microbiology and Infectious Disease, Vol. 93, No. 1, 01.01.2019, p. 69-73.

Research output: Contribution to journalArticle

Rolfes, MC, Sriaroon, P, Dávila Saldaña, BJ, Dvorak, CC, Chapdelaine, H, Ferdman, RM, Chen, K, Jolles, S, Patel, NC, Kim, YJ, Tarrant, TK, Martelius, T, Seppanen, M & Joshi, AY 2019, 'Chronic norovirus infection in primary immune deficiency disorders: an international case series', Diagnostic Microbiology and Infectious Disease, vol. 93, no. 1, pp. 69-73. https://doi.org/10.1016/j.diagmicrobio.2018.08.002
Rolfes, M. C. ; Sriaroon, P. ; Dávila Saldaña, B. J. ; Dvorak, C. C. ; Chapdelaine, H. ; Ferdman, R. M. ; Chen, K. ; Jolles, S. ; Patel, N. C. ; Kim, Y. J. ; Tarrant, Teresa K ; Martelius, T. ; Seppanen, M. ; Joshi, A. Y. / Chronic norovirus infection in primary immune deficiency disorders : an international case series. In: Diagnostic Microbiology and Infectious Disease. 2019 ; Vol. 93, No. 1. pp. 69-73.
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