Chimeric Vectors

Dawn E. Bowles (Inventor), Chengwen Li (Inventor), Joseph E. Rabinowitz (Inventor), Josh Grieger (Inventor), Mavis Agbandje-McKenna (Inventor), Richard Jude Samulski (Inventor)

Research output: ResearchPatent

Abstract

The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
LanguageEnglish
Patent number7892809
IPCC12N 7/01 (20060101)
StatePublished - 1800

Fingerprint

Protoparvovirus
capsid
Parvoviridae
amino acids

Cite this

Bowles, D. E., Li, C., Rabinowitz, J. E., Grieger, J., Agbandje-McKenna, M., & Samulski, R. J. (1800). IPC No. C12N 7/01 (20060101). Chimeric Vectors (Patent No. 7892809.)

Chimeric Vectors. / Bowles, Dawn E. (Inventor); Li, Chengwen (Inventor); Rabinowitz, Joseph E. (Inventor); Grieger, Josh (Inventor); Agbandje-McKenna, Mavis (Inventor); Samulski, Richard Jude (Inventor).

IPC No.: C12N 7/01 (20060101). Patent No.: 7892809.

Research output: ResearchPatent

Bowles, DE, Li, C, Rabinowitz, JE, Grieger, J, Agbandje-McKenna, M & Samulski, RJ 1800, Chimeric Vectors, Patent No. 7892809, IPC No. C12N 7/01 (20060101).
Bowles DE, Li C, Rabinowitz JE, Grieger J, Agbandje-McKenna M, Samulski RJ, inventors. Chimeric Vectors. C12N 7/01 (20060101). 1800
Bowles, Dawn E. (Inventor) ; Li, Chengwen (Inventor) ; Rabinowitz, Joseph E. (Inventor) ; Grieger, Josh (Inventor) ; Agbandje-McKenna, Mavis (Inventor) ; Samulski, Richard Jude (Inventor). / Chimeric Vectors. IPC No.: C12N 7/01 (20060101). Patent No.: 7892809.
@misc{84fdd10258b54d828cfa9f881d865b28,
title = "Chimeric Vectors",
abstract = "The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.",
author = "Bowles, {Dawn E.} and Chengwen Li and Rabinowitz, {Joseph E.} and Josh Grieger and Mavis Agbandje-McKenna and Samulski, {Richard Jude}",
note = "Status: published applicationnumber: 11/793,430 usclass: 435/235.1 ; 435/320.1; 536/24.5 applicationnumber: 11/793,430; 7892809; C12N 7/01 (20060101)",
year = "1800",
type = "Patent",

}

TY - PAT

T1 - Chimeric Vectors

AU - Bowles,Dawn E.

AU - Li,Chengwen

AU - Rabinowitz,Joseph E.

AU - Grieger,Josh

AU - Agbandje-McKenna,Mavis

AU - Samulski,Richard Jude

N1 - Status: published applicationnumber: 11/793,430 usclass: 435/235.1 ; 435/320.1; 536/24.5 applicationnumber: 11/793,430

PY - 1800

Y1 - 1800

N2 - The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

AB - The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

M3 - Patent

M1 - 7892809

ER -