CHAPTER 2: New Screening Approaches for Kinases

D. H. Drewry, B. W. King, C. I. Wells, William J Zuercher

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Kinases are important targets for drug discovery as evidenced by the US FDA approval of over 30 small molecule kinase inhibitors over the last two decades. A wide range of assay technologies have been utilized to quantify inhibitor activity or binding and to assess inhibitor selectivity across the kinome. In this chapter we review some of the modern and perhaps non-traditional methods being used in academic and industrial laboratories, including fragment based approaches DNA encoded library technology (ELT), differential scanning fluorimetry (DSF), chemical proteomics and cellular screening. We highlight the potential advantages offered by each of these methods, along with some of the potential issues and provide illustrative examples.

LanguageEnglish (US)
Title of host publicationTherapies for Retinal Degeneration
Subtitle of host publicationTargeting Common Processes
EditorsRichard A. Ward, Frederick W. Goldberg
PublisherRoyal Society of Chemistry
Pages9-33
Number of pages25
Edition67
DOIs
StatePublished - Jan 1 2019

Publication series

NameRSC Drug Discovery Series
No.67
Volume2019-January
ISSN (Print)2041-3203
ISSN (Electronic)2041-3211

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ASJC Scopus subject areas

  • Drug Discovery

Cite this

Drewry, D. H., King, B. W., Wells, C. I., & Zuercher, W. J. (2019). CHAPTER 2: New Screening Approaches for Kinases. In R. A. Ward, & F. W. Goldberg (Eds.), Therapies for Retinal Degeneration: Targeting Common Processes (67 ed., pp. 9-33). (RSC Drug Discovery Series; Vol. 2019-January, No. 67). Royal Society of Chemistry. https://doi.org/10.1039/9781788013093-00009

CHAPTER 2 : New Screening Approaches for Kinases. / Drewry, D. H.; King, B. W.; Wells, C. I.; Zuercher, William J.

Therapies for Retinal Degeneration: Targeting Common Processes. ed. / Richard A. Ward; Frederick W. Goldberg. 67. ed. Royal Society of Chemistry, 2019. p. 9-33 (RSC Drug Discovery Series; Vol. 2019-January, No. 67).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drewry, DH, King, BW, Wells, CI & Zuercher, WJ 2019, CHAPTER 2: New Screening Approaches for Kinases. in RA Ward & FW Goldberg (eds), Therapies for Retinal Degeneration: Targeting Common Processes. 67 edn, RSC Drug Discovery Series, no. 67, vol. 2019-January, Royal Society of Chemistry, pp. 9-33. https://doi.org/10.1039/9781788013093-00009
Drewry DH, King BW, Wells CI, Zuercher WJ. CHAPTER 2: New Screening Approaches for Kinases. In Ward RA, Goldberg FW, editors, Therapies for Retinal Degeneration: Targeting Common Processes. 67 ed. Royal Society of Chemistry. 2019. p. 9-33. (RSC Drug Discovery Series; 67). https://doi.org/10.1039/9781788013093-00009
Drewry, D. H. ; King, B. W. ; Wells, C. I. ; Zuercher, William J. / CHAPTER 2 : New Screening Approaches for Kinases. Therapies for Retinal Degeneration: Targeting Common Processes. editor / Richard A. Ward ; Frederick W. Goldberg. 67. ed. Royal Society of Chemistry, 2019. pp. 9-33 (RSC Drug Discovery Series; 67).
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