Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas sp.)

Peter Kochunov, Hsiao Ying Wey, Peter T. Fox, Jack L. Lancaster, Michael D. Davis, Danny J.J. Wang, Ai Ling Lin, Raul A. Bastarrachea, Marcia C.R. Andrade, Vicki Mattern, Patrice Frost, Paul B. Higgins, Anthony G. Comuzzie, Venkata S. Voruganti

Research output: Contribution to journalArticle

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Abstract

Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38.9 mg/dL and declined to 133.4 ± 22.0 mg/dL, at the end of the experiment. Regional CBF changes consisted of four clusters: cerebral cortex, thalamus, hypothalamus, and mesencephalon. Increases in the hypothalamic blood flow occurred concurrently with the regulatory response to systemic glucose change, whereas CBF declined for other clusters. The return to baseline of hypothalamic blood flow was observed while CBF was still increasing in other brain regions. The spatial pattern of extra-hypothalamic CBF changes was correlated with the patterns of several cerebral networks including the default mode network. These findings suggest that hypothalamic blood flow response to systemic glucose levels can potentially be explained by regulatory activity. The response of extra-hypothalamic clusters followed a different time course and its spatial pattern resembled that of the default-mode network.

LanguageEnglish (US)
Article number49
JournalFrontiers in Neuroscience
Volume11
Issue numberFEB
DOIs
StatePublished - Feb 14 2017

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Cerebrovascular Circulation
Papio hamadryas
Primates
Glucose
Blood Glucose
Papio
Magnetic Resonance Angiography
Regional Blood Flow
Mesencephalon
Thalamus
Cerebral Cortex
General Anesthesia
Hypothalamus
Insulin
Brain

Keywords

  • Arterial spin labeling
  • Cerebral blood flow
  • Default state network
  • Hyperglycemic challenge
  • Perfusion imaging
  • Resting state network

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas sp.). / Kochunov, Peter; Wey, Hsiao Ying; Fox, Peter T.; Lancaster, Jack L.; Davis, Michael D.; Wang, Danny J.J.; Lin, Ai Ling; Bastarrachea, Raul A.; Andrade, Marcia C.R.; Mattern, Vicki; Frost, Patrice; Higgins, Paul B.; Comuzzie, Anthony G.; Voruganti, Venkata S.

In: Frontiers in Neuroscience, Vol. 11, No. FEB, 49, 14.02.2017.

Research output: Contribution to journalArticle

Kochunov, P, Wey, HY, Fox, PT, Lancaster, JL, Davis, MD, Wang, DJJ, Lin, AL, Bastarrachea, RA, Andrade, MCR, Mattern, V, Frost, P, Higgins, PB, Comuzzie, AG & Voruganti, VS 2017, 'Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas sp.)' Frontiers in Neuroscience, vol 11, no. FEB, 49. DOI: 10.3389/fnins.2017.00049
Kochunov P, Wey HY, Fox PT, Lancaster JL, Davis MD, Wang DJJ et al. Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas sp.). Frontiers in Neuroscience. 2017 Feb 14;11(FEB). 49. Available from, DOI: 10.3389/fnins.2017.00049
Kochunov, Peter ; Wey, Hsiao Ying ; Fox, Peter T. ; Lancaster, Jack L. ; Davis, Michael D. ; Wang, Danny J.J. ; Lin, Ai Ling ; Bastarrachea, Raul A. ; Andrade, Marcia C.R. ; Mattern, Vicki ; Frost, Patrice ; Higgins, Paul B. ; Comuzzie, Anthony G. ; Voruganti, Venkata S./ Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas sp.). In: Frontiers in Neuroscience. 2017 ; Vol. 11, No. FEB.
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