Cell-Cycle-Dependent Regulation of Cell Adhesions: Adhering to the Schedule: Three papers reveal unexpected properties of adhesion structures as cells progress through the cell cycle

Research output: Contribution to journalReview article

Abstract

Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, paxillin, and zyxin. Re-examining cell-matrix adhesion reveals reticular adhesions, a new class of adhesion. These αVβ5 integrin-mediated adhesions also lack conventional focal adhesion components and anchor mitotic cells to the extracellular matrix. As reviewed here, these studies present insight into how adhesion complexes vary through the cell cycle, and how unconventional adhesions maintain attachment during mitosis while providing spatial memory to guide daughter cell re-spreading after cell division.

LanguageEnglish (US)
Article number1800165
JournalBioEssays
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2019

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Focal Adhesions
Cell adhesion
Cell Adhesion
Appointments and Schedules
Cell Cycle
Adhesion
Cells
Mitosis
Integrins
Cell Division
Zyxin
Talin
Cell-Matrix Junctions
Paxillin
S Phase
Extracellular Matrix
Anchors

Keywords

  • CDK1
  • cell cycle
  • focal adhesions
  • integrin
  • mitosis
  • reticular adhesions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Cell-Cycle-Dependent Regulation of Cell Adhesions: Adhering to the Schedule: Three papers reveal unexpected properties of adhesion structures as cells progress through the cell cycle",
abstract = "Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, paxillin, and zyxin. Re-examining cell-matrix adhesion reveals reticular adhesions, a new class of adhesion. These αVβ5 integrin-mediated adhesions also lack conventional focal adhesion components and anchor mitotic cells to the extracellular matrix. As reviewed here, these studies present insight into how adhesion complexes vary through the cell cycle, and how unconventional adhesions maintain attachment during mitosis while providing spatial memory to guide daughter cell re-spreading after cell division.",
keywords = "CDK1, cell cycle, focal adhesions, integrin, mitosis, reticular adhesions",
author = "Yitong Li and Burridge, {Keith W T}",
year = "2019",
month = "1",
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volume = "41",
journal = "BioEssays",
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N2 - Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, paxillin, and zyxin. Re-examining cell-matrix adhesion reveals reticular adhesions, a new class of adhesion. These αVβ5 integrin-mediated adhesions also lack conventional focal adhesion components and anchor mitotic cells to the extracellular matrix. As reviewed here, these studies present insight into how adhesion complexes vary through the cell cycle, and how unconventional adhesions maintain attachment during mitosis while providing spatial memory to guide daughter cell re-spreading after cell division.

AB - Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, paxillin, and zyxin. Re-examining cell-matrix adhesion reveals reticular adhesions, a new class of adhesion. These αVβ5 integrin-mediated adhesions also lack conventional focal adhesion components and anchor mitotic cells to the extracellular matrix. As reviewed here, these studies present insight into how adhesion complexes vary through the cell cycle, and how unconventional adhesions maintain attachment during mitosis while providing spatial memory to guide daughter cell re-spreading after cell division.

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KW - focal adhesions

KW - integrin

KW - mitosis

KW - reticular adhesions

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