Bioactive chemical constituents from the root bark of Morus australis

Yu Ren Liao, Ping Chung Kuo, Wei Jern Tsai, Guan Jhong Huang, Kuo Hsiung Lee, Tian Shung Wu

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50 values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50 values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.

LanguageEnglish (US)
Pages309-313
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number2
DOIs
StatePublished - Jan 15 2017

Fingerprint

Morus
Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
Platelets
Agglomeration
Benzene Derivatives
Platelet Activating Factor
Benzene
Nitric Oxide
RAW 264.7 Cells

Keywords

  • Anti-platelet aggregation
  • Morus australis
  • NO inhibitory activity
  • Pyranoflavonoid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Bioactive chemical constituents from the root bark of Morus australis. / Liao, Yu Ren; Kuo, Ping Chung; Tsai, Wei Jern; Huang, Guan Jhong; Lee, Kuo Hsiung; Wu, Tian Shung.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 27, No. 2, 15.01.2017, p. 309-313.

Research output: Research - peer-reviewArticle

Liao, Yu Ren ; Kuo, Ping Chung ; Tsai, Wei Jern ; Huang, Guan Jhong ; Lee, Kuo Hsiung ; Wu, Tian Shung. / Bioactive chemical constituents from the root bark of Morus australis. In: Bioorganic and Medicinal Chemistry Letters. 2017 ; Vol. 27, No. 2. pp. 309-313
@article{1aa9d47b54ce4b49b1feef6251374090,
title = "Bioactive chemical constituents from the root bark of Morus australis",
abstract = "Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50 values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50 values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.",
keywords = "Anti-platelet aggregation, Morus australis, NO inhibitory activity, Pyranoflavonoid",
author = "Liao, {Yu Ren} and Kuo, {Ping Chung} and Tsai, {Wei Jern} and Huang, {Guan Jhong} and Lee, {Kuo Hsiung} and Wu, {Tian Shung}",
year = "2017",
month = "1",
doi = "10.1016/j.bmcl.2016.11.046",
volume = "27",
pages = "309--313",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Bioactive chemical constituents from the root bark of Morus australis

AU - Liao,Yu Ren

AU - Kuo,Ping Chung

AU - Tsai,Wei Jern

AU - Huang,Guan Jhong

AU - Lee,Kuo Hsiung

AU - Wu,Tian Shung

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50 values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50 values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.

AB - Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50 values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50 values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.

KW - Anti-platelet aggregation

KW - Morus australis

KW - NO inhibitory activity

KW - Pyranoflavonoid

UR - http://www.scopus.com/inward/record.url?scp=85006943654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006943654&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2016.11.046

DO - 10.1016/j.bmcl.2016.11.046

M3 - Article

VL - 27

SP - 309

EP - 313

JO - Bioorganic and Medicinal Chemistry Letters

T2 - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 2

ER -