Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS)

Michelle L. Meyer, Priya Palta, Hirofumi Tanaka, Jennifer A. Deal, Jacqueline Wright, David S. Knopman, Michael E. Griswold, Thomas H. Mosley, Gerardo Heiss

Research output: Contribution to journalArticle

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Abstract

Background: The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. Objective: The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study. Methods: We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment. Results: Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants <75th percentile (conditional odds ratio (OR); 95 confidence interval (CI): 1.27 (1.02, 1.56) and 1.28 (1.04, 1.57), respectively) and those with central pulse pressure ≥75th percentile had a higher prevalence of MCI (OR 1.27 (95 CI: 1.03, 1.58)) and dementia (OR 1.76 (95 CI: 1.06, 2.92) compared to participants <75th percentile. Also among whites, those with pulse pressure amplification ≤25th percentile had a higher prevalence of dementia compared to participants >25th percentile (OR 1.65; (95 CI: 1.01, 2.70). Weaker associations were seen among black participants. Conclusion: Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness and pressure pulsatility predict MCI and dementia among older adults.

LanguageEnglish (US)
Pages195-204
Number of pages10
JournalJournal of Alzheimer's Disease
Volume57
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Vascular Stiffness
Dementia
Atherosclerosis
Arterial Pressure
Blood Pressure
Odds Ratio
Confidence Intervals
Pulse Wave Analysis
Thigh
Cognitive Dysfunction
Population
Logistic Models

Keywords

  • Alzheimer's disease
  • brain
  • cognition
  • dementia
  • mild cognitive impairment
  • pulse wave velocity

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia : The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS). / Meyer, Michelle L.; Palta, Priya; Tanaka, Hirofumi; Deal, Jennifer A.; Wright, Jacqueline; Knopman, David S.; Griswold, Michael E.; Mosley, Thomas H.; Heiss, Gerardo.

In: Journal of Alzheimer's Disease, Vol. 57, No. 1, 2017, p. 195-204.

Research output: Contribution to journalArticle

Meyer, Michelle L. ; Palta, Priya ; Tanaka, Hirofumi ; Deal, Jennifer A. ; Wright, Jacqueline ; Knopman, David S. ; Griswold, Michael E. ; Mosley, Thomas H. ; Heiss, Gerardo. / Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia : The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS). In: Journal of Alzheimer's Disease. 2017 ; Vol. 57, No. 1. pp. 195-204
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abstract = "Background: The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. Objective: The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study. Methods: We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment. Results: Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants <75th percentile (conditional odds ratio (OR); 95 confidence interval (CI): 1.27 (1.02, 1.56) and 1.28 (1.04, 1.57), respectively) and those with central pulse pressure ≥75th percentile had a higher prevalence of MCI (OR 1.27 (95 CI: 1.03, 1.58)) and dementia (OR 1.76 (95 CI: 1.06, 2.92) compared to participants <75th percentile. Also among whites, those with pulse pressure amplification ≤25th percentile had a higher prevalence of dementia compared to participants >25th percentile (OR 1.65; (95 CI: 1.01, 2.70). Weaker associations were seen among black participants. Conclusion: Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness and pressure pulsatility predict MCI and dementia among older adults.",
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T1 - Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia

T2 - Journal of Alzheimer's Disease

AU - Meyer,Michelle L.

AU - Palta,Priya

AU - Tanaka,Hirofumi

AU - Deal,Jennifer A.

AU - Wright,Jacqueline

AU - Knopman,David S.

AU - Griswold,Michael E.

AU - Mosley,Thomas H.

AU - Heiss,Gerardo

PY - 2017

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N2 - Background: The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. Objective: The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study. Methods: We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment. Results: Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants <75th percentile (conditional odds ratio (OR); 95 confidence interval (CI): 1.27 (1.02, 1.56) and 1.28 (1.04, 1.57), respectively) and those with central pulse pressure ≥75th percentile had a higher prevalence of MCI (OR 1.27 (95 CI: 1.03, 1.58)) and dementia (OR 1.76 (95 CI: 1.06, 2.92) compared to participants <75th percentile. Also among whites, those with pulse pressure amplification ≤25th percentile had a higher prevalence of dementia compared to participants >25th percentile (OR 1.65; (95 CI: 1.01, 2.70). Weaker associations were seen among black participants. Conclusion: Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness and pressure pulsatility predict MCI and dementia among older adults.

AB - Background: The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. Objective: The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study. Methods: We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment. Results: Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants <75th percentile (conditional odds ratio (OR); 95 confidence interval (CI): 1.27 (1.02, 1.56) and 1.28 (1.04, 1.57), respectively) and those with central pulse pressure ≥75th percentile had a higher prevalence of MCI (OR 1.27 (95 CI: 1.03, 1.58)) and dementia (OR 1.76 (95 CI: 1.06, 2.92) compared to participants <75th percentile. Also among whites, those with pulse pressure amplification ≤25th percentile had a higher prevalence of dementia compared to participants >25th percentile (OR 1.65; (95 CI: 1.01, 2.70). Weaker associations were seen among black participants. Conclusion: Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness and pressure pulsatility predict MCI and dementia among older adults.

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KW - brain

KW - cognition

KW - dementia

KW - mild cognitive impairment

KW - pulse wave velocity

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