Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants

Erik A. Jensen, Kevin C. Dysart, Marie G. Gantz, Benjamin Carper, Rosemary D. Higgins, Martin Keszler, Matthew M. Laughon, Brenda B. Poindexter, Barbara J. Stoll, Michele C. Walsh, Barbara Schmidt, Michael S. Caplan, Richard A. Polin, Abbot R. Laptook, Martin Keszler, Angelita M. Hensman, Kristin M. Basso, Elisa Vieira, Emily Little, Avroy A. Fanaroff & 136 others Anna Marie Hibbs, Nancy S. Newman, William E. Truog, Howard W. Kilbride, Eugenia K. Pallotto, Cheri Gauldin, Anne Holmes, Kathy Johnson, Allison Knutson, Kurt Schibler, Edward F. Donovan, Barbara Alexander, Cathy Grisby, Jody Hessling, Estelle E. Fischer, Lenora D. Jackson, Kristin Kirker, Greg Muthig, Ronald N. Goldberg, C. Michael Cotten, Kimberley A. Fisher, Kathy J. Auten, Katherine A. Foy, Sandra Grimes, Joanne Finkle, Matthew M. Laughon, Carl L. Bose, Janice Bernhardt, Gennie Bose, David P. Carlton, Ellen C. Hale, Stephanie Wilson Archer, Brenda B. Poindexter, Gregory M. Sokol, Leslie Dawn Wilson, Dianne E. Herron, Pablo J. Sánchez, Leif D. Nelin, Sudarshan R. Jadcherla, Patricia Luzader, Christine A. Fortney, Gail E. Besner, Nehal A. Parikh, Abhik Das, Dennis Wallace, Jeanette O.Donnell Auman, Margaret M. Crawford, Carolyn M. Petrie Huitema, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, Marian M. Adams, David K. Stevenson, M. Bethany Ball, Andrew W. Palmquist, Melinda S. Proud, Ivan D. Frantz, John M. Fiascone, Brenda L. MacKinnon, Ellen Nylen, Waldemar A. Carlo, Namasivayam Ambalavanan, Monica V. Collins, Shirley S. Cosby, Uday Devaskar, Meena Garg, Teresa Chanlaw, Rachel Geller, Edward F. Bell, Dan L. Ellsbury, John A. Widness, Karen J. Johnson, Donia B. Campbell, Kristi L. Watterberg, Robin K. Ohls, Conra Backstrom Lacy, Rebecca A. Montman, Sandra Brown, Theresa Wussow, Carol Hartenberger, Barbara Schmidt, Haresh Kirpalani, Sara B. DeMauro, Aasma S. Chaudhary, Soraya Abbasi, Toni Mancini, Dara M. Cucinotta, Carl T. D'Angio, Ronnie Guillet, Satyan Lakshminrusimha, Ann Marie Reynolds, Linda J. Reubens, Rosemary Jensen, Deana Maffett, Holly I.M. Wadkins, Michael G. Sacilowski, Ashley Williams, Stephanie Guilford, Cassandra A. Horihan, Kathleen A. Kennedy, Jon E. Tyson, Katrina Burson, Beverly Foley Harris, Georgia E. McDavid, Patti L. Pierce Tate, Sharon L. Wright, Pablo J. Sánchez, Luc P. Brion, Lijun Chen, Alicia Guzman, Melissa H. Leps, Nancy A. Miller, Janet S. Morgan, Diana M. Vasil, Lizette E. Torres, Roger G. Faix, Bradley A. Yoder, Karen A. Osborne, Karie Bird, Jill Burnett, Jennifer J. Jensen, Cynthia Spencer, Kimberlee Weaver-Lewis, Karen Zanetti, Seetha Shankaran, John Barks, Rebecca Bara, Mary Johnson, Mary Christensen, Stephanie Wiggins, Richard A. Ehrenkranz, Harris Jacobs, Patricia Cervone, Monica Konstantino, Jo Ann Poulsen, Janet Taft,

Research output: Research - peer-reviewArticle

  • 2 Citations

Abstract

Objective To assess the association between prophylactic indomethacin and bronchopulmonary dysplasia (BPD) in a recent, large cohort of extremely preterm infants. Study design Retrospective cohort study using prospectively collected data for infants with gestational ages < 29 weeks or birth weights of 401-1000 g born between 2008 and 2012 at participating hospitals of the National Institute of Child Health and Human Development Neonatal Research Network. Infants treated with indomethacin in the first 24 hours of life were compared with those who were not. Study outcomes were BPD, defined as use of supplemental oxygen at 36 weeks postmenstrual age among survivors to that time point, death, and the composite of death or BPD. Prespecified subgroup analyses were performed. Results Prophylactic indomethacin use varied by hospital. Treatment of a patent ductus arteriosus after the first day of life was less common among 2587 infants who received prophylactic indomethacin compared with 5244 who did not (21.0% vs 36.1%, P < .001). After adjustment for potential confounders, use of prophylactic indomethacin was not associated with higher or lower odds of BPD (OR 0.89, 95% CI 0.72-1.10), death (OR 0.80, 95% CI 0.64-1.01), or death or BPD (OR 0.87, 95% CI 0.71-1.05). The only evidence of subgroup effects associated with prophylactic indomethacin were lower odds of death among infants with birth weights above the 10th percentile and those who were not treated for a patent ductus arteriosus after the first day of life. Conclusions Prophylactic indomethacin was not associated with either reduced or increased risk for BPD or death. Trial registration ClinicalTrials.gov: NCT00063063

LanguageEnglish (US)
Pages34-40.e2
JournalJournal of Pediatrics
Volume186
DOIs
StatePublished - Jul 1 2017

Fingerprint

Extremely Premature Infants
Bronchopulmonary Dysplasia
Indomethacin
Patent Ductus Arteriosus
Birth Weight
National Institute of Child Health and Human Development (U.S.)
Gestational Age
Survivors
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)
Oxygen
Research
Therapeutics
Infant Death

Keywords

  • bronchopulmonary dysplasia
  • extreme prematurity
  • indomethacin
  • prophylaxis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Jensen, E. A., Dysart, K. C., Gantz, M. G., Carper, B., Higgins, R. D., Keszler, M., ... Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2017). Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. Journal of Pediatrics, 186, 34-40.e2. DOI: 10.1016/j.jpeds.2017.02.003

Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. / Jensen, Erik A.; Dysart, Kevin C.; Gantz, Marie G.; Carper, Benjamin; Higgins, Rosemary D.; Keszler, Martin; Laughon, Matthew M.; Poindexter, Brenda B.; Stoll, Barbara J.; Walsh, Michele C.; Schmidt, Barbara; Caplan, Michael S.; Polin, Richard A.; Laptook, Abbot R.; Keszler, Martin; Hensman, Angelita M.; Basso, Kristin M.; Vieira, Elisa; Little, Emily; Fanaroff, Avroy A.; Hibbs, Anna Marie; Newman, Nancy S.; Truog, William E.; Kilbride, Howard W.; Pallotto, Eugenia K.; Gauldin, Cheri; Holmes, Anne; Johnson, Kathy; Knutson, Allison; Schibler, Kurt; Donovan, Edward F.; Alexander, Barbara; Grisby, Cathy; Hessling, Jody; Fischer, Estelle E.; Jackson, Lenora D.; Kirker, Kristin; Muthig, Greg; Goldberg, Ronald N.; Cotten, C. Michael; Fisher, Kimberley A.; Auten, Kathy J.; Foy, Katherine A.; Grimes, Sandra; Finkle, Joanne; Laughon, Matthew M.; Bose, Carl L.; Bernhardt, Janice; Bose, Gennie; Carlton, David P.; Hale, Ellen C.; Archer, Stephanie Wilson; Poindexter, Brenda B.; Sokol, Gregory M.; Wilson, Leslie Dawn; Herron, Dianne E.; Sánchez, Pablo J.; Nelin, Leif D.; Jadcherla, Sudarshan R.; Luzader, Patricia; Fortney, Christine A.; Besner, Gail E.; Parikh, Nehal A.; Das, Abhik; Wallace, Dennis; Auman, Jeanette O.Donnell; Crawford, Margaret M.; Petrie Huitema, Carolyn M.; Zaterka-Baxter, Kristin M.; Van Meurs, Krisa P.; Adams, Marian M.; Stevenson, David K.; Ball, M. Bethany; Palmquist, Andrew W.; Proud, Melinda S.; Frantz, Ivan D.; Fiascone, John M.; MacKinnon, Brenda L.; Nylen, Ellen; Carlo, Waldemar A.; Ambalavanan, Namasivayam; Collins, Monica V.; Cosby, Shirley S.; Devaskar, Uday; Garg, Meena; Chanlaw, Teresa; Geller, Rachel; Bell, Edward F.; Ellsbury, Dan L.; Widness, John A.; Johnson, Karen J.; Campbell, Donia B.; Watterberg, Kristi L.; Ohls, Robin K.; Lacy, Conra Backstrom; Montman, Rebecca A.; Brown, Sandra; Wussow, Theresa; Hartenberger, Carol; Schmidt, Barbara; Kirpalani, Haresh; DeMauro, Sara B.; Chaudhary, Aasma S.; Abbasi, Soraya; Mancini, Toni; Cucinotta, Dara M.; D'Angio, Carl T.; Guillet, Ronnie; Lakshminrusimha, Satyan; Reynolds, Ann Marie; Reubens, Linda J.; Jensen, Rosemary; Maffett, Deana; Wadkins, Holly I.M.; Sacilowski, Michael G.; Williams, Ashley; Guilford, Stephanie; Horihan, Cassandra A.; Kennedy, Kathleen A.; Tyson, Jon E.; Burson, Katrina; Harris, Beverly Foley; McDavid, Georgia E.; Pierce Tate, Patti L.; Wright, Sharon L.; Sánchez, Pablo J.; Brion, Luc P.; Chen, Lijun; Guzman, Alicia; Leps, Melissa H.; Miller, Nancy A.; Morgan, Janet S.; Vasil, Diana M.; Torres, Lizette E.; Faix, Roger G.; Yoder, Bradley A.; Osborne, Karen A.; Bird, Karie; Burnett, Jill; Jensen, Jennifer J.; Spencer, Cynthia; Weaver-Lewis, Kimberlee; Zanetti, Karen; Shankaran, Seetha; Barks, John; Bara, Rebecca; Johnson, Mary; Christensen, Mary; Wiggins, Stephanie; Ehrenkranz, Richard A.; Jacobs, Harris; Cervone, Patricia; Konstantino, Monica; Poulsen, Jo Ann; Taft, Janet; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

In: Journal of Pediatrics, Vol. 186, 01.07.2017, p. 34-40.e2.

Research output: Research - peer-reviewArticle

Jensen, EA, Dysart, KC, Gantz, MG, Carper, B, Higgins, RD, Keszler, M, Laughon, MM, Poindexter, BB, Stoll, BJ, Walsh, MC, Schmidt, B, Caplan, MS, Polin, RA, Laptook, AR, Keszler, M, Hensman, AM, Basso, KM, Vieira, E, Little, E, Fanaroff, AA, Hibbs, AM, Newman, NS, Truog, WE, Kilbride, HW, Pallotto, EK, Gauldin, C, Holmes, A, Johnson, K, Knutson, A, Schibler, K, Donovan, EF, Alexander, B, Grisby, C, Hessling, J, Fischer, EE, Jackson, LD, Kirker, K, Muthig, G, Goldberg, RN, Cotten, CM, Fisher, KA, Auten, KJ, Foy, KA, Grimes, S, Finkle, J, Laughon, MM, Bose, CL, Bernhardt, J, Bose, G, Carlton, DP, Hale, EC, Archer, SW, Poindexter, BB, Sokol, GM, Wilson, LD, Herron, DE, Sánchez, PJ, Nelin, LD, Jadcherla, SR, Luzader, P, Fortney, CA, Besner, GE, Parikh, NA, Das, A, Wallace, D, Auman, JOD, Crawford, MM, Petrie Huitema, CM, Zaterka-Baxter, KM, Van Meurs, KP, Adams, MM, Stevenson, DK, Ball, MB, Palmquist, AW, Proud, MS, Frantz, ID, Fiascone, JM, MacKinnon, BL, Nylen, E, Carlo, WA, Ambalavanan, N, Collins, MV, Cosby, SS, Devaskar, U, Garg, M, Chanlaw, T, Geller, R, Bell, EF, Ellsbury, DL, Widness, JA, Johnson, KJ, Campbell, DB, Watterberg, KL, Ohls, RK, Lacy, CB, Montman, RA, Brown, S, Wussow, T, Hartenberger, C, Schmidt, B, Kirpalani, H, DeMauro, SB, Chaudhary, AS, Abbasi, S, Mancini, T, Cucinotta, DM, D'Angio, CT, Guillet, R, Lakshminrusimha, S, Reynolds, AM, Reubens, LJ, Jensen, R, Maffett, D, Wadkins, HIM, Sacilowski, MG, Williams, A, Guilford, S, Horihan, CA, Kennedy, KA, Tyson, JE, Burson, K, Harris, BF, McDavid, GE, Pierce Tate, PL, Wright, SL, Sánchez, PJ, Brion, LP, Chen, L, Guzman, A, Leps, MH, Miller, NA, Morgan, JS, Vasil, DM, Torres, LE, Faix, RG, Yoder, BA, Osborne, KA, Bird, K, Burnett, J, Jensen, JJ, Spencer, C, Weaver-Lewis, K, Zanetti, K, Shankaran, S, Barks, J, Bara, R, Johnson, M, Christensen, M, Wiggins, S, Ehrenkranz, RA, Jacobs, H, Cervone, P, Konstantino, M, Poulsen, JA, Taft, J & Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network 2017, 'Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants' Journal of Pediatrics, vol 186, pp. 34-40.e2. DOI: 10.1016/j.jpeds.2017.02.003
Jensen EA, Dysart KC, Gantz MG, Carper B, Higgins RD, Keszler M et al. Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. Journal of Pediatrics. 2017 Jul 1;186:34-40.e2. Available from, DOI: 10.1016/j.jpeds.2017.02.003
Jensen, Erik A. ; Dysart, Kevin C. ; Gantz, Marie G. ; Carper, Benjamin ; Higgins, Rosemary D. ; Keszler, Martin ; Laughon, Matthew M. ; Poindexter, Brenda B. ; Stoll, Barbara J. ; Walsh, Michele C. ; Schmidt, Barbara ; Caplan, Michael S. ; Polin, Richard A. ; Laptook, Abbot R. ; Keszler, Martin ; Hensman, Angelita M. ; Basso, Kristin M. ; Vieira, Elisa ; Little, Emily ; Fanaroff, Avroy A. ; Hibbs, Anna Marie ; Newman, Nancy S. ; Truog, William E. ; Kilbride, Howard W. ; Pallotto, Eugenia K. ; Gauldin, Cheri ; Holmes, Anne ; Johnson, Kathy ; Knutson, Allison ; Schibler, Kurt ; Donovan, Edward F. ; Alexander, Barbara ; Grisby, Cathy ; Hessling, Jody ; Fischer, Estelle E. ; Jackson, Lenora D. ; Kirker, Kristin ; Muthig, Greg ; Goldberg, Ronald N. ; Cotten, C. Michael ; Fisher, Kimberley A. ; Auten, Kathy J. ; Foy, Katherine A. ; Grimes, Sandra ; Finkle, Joanne ; Laughon, Matthew M. ; Bose, Carl L. ; Bernhardt, Janice ; Bose, Gennie ; Carlton, David P. ; Hale, Ellen C. ; Archer, Stephanie Wilson ; Poindexter, Brenda B. ; Sokol, Gregory M. ; Wilson, Leslie Dawn ; Herron, Dianne E. ; Sánchez, Pablo J. ; Nelin, Leif D. ; Jadcherla, Sudarshan R. ; Luzader, Patricia ; Fortney, Christine A. ; Besner, Gail E. ; Parikh, Nehal A. ; Das, Abhik ; Wallace, Dennis ; Auman, Jeanette O.Donnell ; Crawford, Margaret M. ; Petrie Huitema, Carolyn M. ; Zaterka-Baxter, Kristin M. ; Van Meurs, Krisa P. ; Adams, Marian M. ; Stevenson, David K. ; Ball, M. Bethany ; Palmquist, Andrew W. ; Proud, Melinda S. ; Frantz, Ivan D. ; Fiascone, John M. ; MacKinnon, Brenda L. ; Nylen, Ellen ; Carlo, Waldemar A. ; Ambalavanan, Namasivayam ; Collins, Monica V. ; Cosby, Shirley S. ; Devaskar, Uday ; Garg, Meena ; Chanlaw, Teresa ; Geller, Rachel ; Bell, Edward F. ; Ellsbury, Dan L. ; Widness, John A. ; Johnson, Karen J. ; Campbell, Donia B. ; Watterberg, Kristi L. ; Ohls, Robin K. ; Lacy, Conra Backstrom ; Montman, Rebecca A. ; Brown, Sandra ; Wussow, Theresa ; Hartenberger, Carol ; Schmidt, Barbara ; Kirpalani, Haresh ; DeMauro, Sara B. ; Chaudhary, Aasma S. ; Abbasi, Soraya ; Mancini, Toni ; Cucinotta, Dara M. ; D'Angio, Carl T. ; Guillet, Ronnie ; Lakshminrusimha, Satyan ; Reynolds, Ann Marie ; Reubens, Linda J. ; Jensen, Rosemary ; Maffett, Deana ; Wadkins, Holly I.M. ; Sacilowski, Michael G. ; Williams, Ashley ; Guilford, Stephanie ; Horihan, Cassandra A. ; Kennedy, Kathleen A. ; Tyson, Jon E. ; Burson, Katrina ; Harris, Beverly Foley ; McDavid, Georgia E. ; Pierce Tate, Patti L. ; Wright, Sharon L. ; Sánchez, Pablo J. ; Brion, Luc P. ; Chen, Lijun ; Guzman, Alicia ; Leps, Melissa H. ; Miller, Nancy A. ; Morgan, Janet S. ; Vasil, Diana M. ; Torres, Lizette E. ; Faix, Roger G. ; Yoder, Bradley A. ; Osborne, Karen A. ; Bird, Karie ; Burnett, Jill ; Jensen, Jennifer J. ; Spencer, Cynthia ; Weaver-Lewis, Kimberlee ; Zanetti, Karen ; Shankaran, Seetha ; Barks, John ; Bara, Rebecca ; Johnson, Mary ; Christensen, Mary ; Wiggins, Stephanie ; Ehrenkranz, Richard A. ; Jacobs, Harris ; Cervone, Patricia ; Konstantino, Monica ; Poulsen, Jo Ann ; Taft, Janet ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. / Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. In: Journal of Pediatrics. 2017 ; Vol. 186. pp. 34-40.e2
@article{bf9b87885a0a46f5988220d7142b1d1d,
title = "Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants",
abstract = "Objective To assess the association between prophylactic indomethacin and bronchopulmonary dysplasia (BPD) in a recent, large cohort of extremely preterm infants. Study design Retrospective cohort study using prospectively collected data for infants with gestational ages < 29 weeks or birth weights of 401-1000 g born between 2008 and 2012 at participating hospitals of the National Institute of Child Health and Human Development Neonatal Research Network. Infants treated with indomethacin in the first 24 hours of life were compared with those who were not. Study outcomes were BPD, defined as use of supplemental oxygen at 36 weeks postmenstrual age among survivors to that time point, death, and the composite of death or BPD. Prespecified subgroup analyses were performed. Results Prophylactic indomethacin use varied by hospital. Treatment of a patent ductus arteriosus after the first day of life was less common among 2587 infants who received prophylactic indomethacin compared with 5244 who did not (21.0% vs 36.1%, P < .001). After adjustment for potential confounders, use of prophylactic indomethacin was not associated with higher or lower odds of BPD (OR 0.89, 95% CI 0.72-1.10), death (OR 0.80, 95% CI 0.64-1.01), or death or BPD (OR 0.87, 95% CI 0.71-1.05). The only evidence of subgroup effects associated with prophylactic indomethacin were lower odds of death among infants with birth weights above the 10th percentile and those who were not treated for a patent ductus arteriosus after the first day of life. Conclusions Prophylactic indomethacin was not associated with either reduced or increased risk for BPD or death. Trial registration ClinicalTrials.gov: NCT00063063",
keywords = "bronchopulmonary dysplasia, extreme prematurity, indomethacin, prophylaxis",
author = "Jensen, {Erik A.} and Dysart, {Kevin C.} and Gantz, {Marie G.} and Benjamin Carper and Higgins, {Rosemary D.} and Martin Keszler and Laughon, {Matthew M.} and Poindexter, {Brenda B.} and Stoll, {Barbara J.} and Walsh, {Michele C.} and Barbara Schmidt and Caplan, {Michael S.} and Polin, {Richard A.} and Laptook, {Abbot R.} and Martin Keszler and Hensman, {Angelita M.} and Basso, {Kristin M.} and Elisa Vieira and Emily Little and Fanaroff, {Avroy A.} and Hibbs, {Anna Marie} and Newman, {Nancy S.} and Truog, {William E.} and Kilbride, {Howard W.} and Pallotto, {Eugenia K.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Allison Knutson and Kurt Schibler and Donovan, {Edward F.} and Barbara Alexander and Cathy Grisby and Jody Hessling and Fischer, {Estelle E.} and Jackson, {Lenora D.} and Kristin Kirker and Greg Muthig and Goldberg, {Ronald N.} and Cotten, {C. Michael} and Fisher, {Kimberley A.} and Auten, {Kathy J.} and Foy, {Katherine A.} and Sandra Grimes and Joanne Finkle and Laughon, {Matthew M.} and Bose, {Carl L.} and Janice Bernhardt and Gennie Bose and Carlton, {David P.} and Hale, {Ellen C.} and Archer, {Stephanie Wilson} and Poindexter, {Brenda B.} and Sokol, {Gregory M.} and Wilson, {Leslie Dawn} and Herron, {Dianne E.} and Sánchez, {Pablo J.} and Nelin, {Leif D.} and Jadcherla, {Sudarshan R.} and Patricia Luzader and Fortney, {Christine A.} and Besner, {Gail E.} and Parikh, {Nehal A.} and Abhik Das and Dennis Wallace and Auman, {Jeanette O.Donnell} and Crawford, {Margaret M.} and {Petrie Huitema}, {Carolyn M.} and Zaterka-Baxter, {Kristin M.} and {Van Meurs}, {Krisa P.} and Adams, {Marian M.} and Stevenson, {David K.} and Ball, {M. Bethany} and Palmquist, {Andrew W.} and Proud, {Melinda S.} and Frantz, {Ivan D.} and Fiascone, {John M.} and MacKinnon, {Brenda L.} and Ellen Nylen and Carlo, {Waldemar A.} and Namasivayam Ambalavanan and Collins, {Monica V.} and Cosby, {Shirley S.} and Uday Devaskar and Meena Garg and Teresa Chanlaw and Rachel Geller and Bell, {Edward F.} and Ellsbury, {Dan L.} and Widness, {John A.} and Johnson, {Karen J.} and Campbell, {Donia B.} and Watterberg, {Kristi L.} and Ohls, {Robin K.} and Lacy, {Conra Backstrom} and Montman, {Rebecca A.} and Sandra Brown and Theresa Wussow and Carol Hartenberger and Barbara Schmidt and Haresh Kirpalani and DeMauro, {Sara B.} and Chaudhary, {Aasma S.} and Soraya Abbasi and Toni Mancini and Cucinotta, {Dara M.} and D'Angio, {Carl T.} and Ronnie Guillet and Satyan Lakshminrusimha and Reynolds, {Ann Marie} and Reubens, {Linda J.} and Rosemary Jensen and Deana Maffett and Wadkins, {Holly I.M.} and Sacilowski, {Michael G.} and Ashley Williams and Stephanie Guilford and Horihan, {Cassandra A.} and Kennedy, {Kathleen A.} and Tyson, {Jon E.} and Katrina Burson and Harris, {Beverly Foley} and McDavid, {Georgia E.} and {Pierce Tate}, {Patti L.} and Wright, {Sharon L.} and Sánchez, {Pablo J.} and Brion, {Luc P.} and Lijun Chen and Alicia Guzman and Leps, {Melissa H.} and Miller, {Nancy A.} and Morgan, {Janet S.} and Vasil, {Diana M.} and Torres, {Lizette E.} and Faix, {Roger G.} and Yoder, {Bradley A.} and Osborne, {Karen A.} and Karie Bird and Jill Burnett and Jensen, {Jennifer J.} and Cynthia Spencer and Kimberlee Weaver-Lewis and Karen Zanetti and Seetha Shankaran and John Barks and Rebecca Bara and Mary Johnson and Mary Christensen and Stephanie Wiggins and Ehrenkranz, {Richard A.} and Harris Jacobs and Patricia Cervone and Monica Konstantino and Poulsen, {Jo Ann} and Janet Taft and {Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network}",
year = "2017",
month = "7",
doi = "10.1016/j.jpeds.2017.02.003",
volume = "186",
pages = "34--40.e2",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

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TY - JOUR

T1 - Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants

AU - Jensen,Erik A.

AU - Dysart,Kevin C.

AU - Gantz,Marie G.

AU - Carper,Benjamin

AU - Higgins,Rosemary D.

AU - Keszler,Martin

AU - Laughon,Matthew M.

AU - Poindexter,Brenda B.

AU - Stoll,Barbara J.

AU - Walsh,Michele C.

AU - Schmidt,Barbara

AU - Caplan,Michael S.

AU - Polin,Richard A.

AU - Laptook,Abbot R.

AU - Keszler,Martin

AU - Hensman,Angelita M.

AU - Basso,Kristin M.

AU - Vieira,Elisa

AU - Little,Emily

AU - Fanaroff,Avroy A.

AU - Hibbs,Anna Marie

AU - Newman,Nancy S.

AU - Truog,William E.

AU - Kilbride,Howard W.

AU - Pallotto,Eugenia K.

AU - Gauldin,Cheri

AU - Holmes,Anne

AU - Johnson,Kathy

AU - Knutson,Allison

AU - Schibler,Kurt

AU - Donovan,Edward F.

AU - Alexander,Barbara

AU - Grisby,Cathy

AU - Hessling,Jody

AU - Fischer,Estelle E.

AU - Jackson,Lenora D.

AU - Kirker,Kristin

AU - Muthig,Greg

AU - Goldberg,Ronald N.

AU - Cotten,C. Michael

AU - Fisher,Kimberley A.

AU - Auten,Kathy J.

AU - Foy,Katherine A.

AU - Grimes,Sandra

AU - Finkle,Joanne

AU - Laughon,Matthew M.

AU - Bose,Carl L.

AU - Bernhardt,Janice

AU - Bose,Gennie

AU - Carlton,David P.

AU - Hale,Ellen C.

AU - Archer,Stephanie Wilson

AU - Poindexter,Brenda B.

AU - Sokol,Gregory M.

AU - Wilson,Leslie Dawn

AU - Herron,Dianne E.

AU - Sánchez,Pablo J.

AU - Nelin,Leif D.

AU - Jadcherla,Sudarshan R.

AU - Luzader,Patricia

AU - Fortney,Christine A.

AU - Besner,Gail E.

AU - Parikh,Nehal A.

AU - Das,Abhik

AU - Wallace,Dennis

AU - Auman,Jeanette O.Donnell

AU - Crawford,Margaret M.

AU - Petrie Huitema,Carolyn M.

AU - Zaterka-Baxter,Kristin M.

AU - Van Meurs,Krisa P.

AU - Adams,Marian M.

AU - Stevenson,David K.

AU - Ball,M. Bethany

AU - Palmquist,Andrew W.

AU - Proud,Melinda S.

AU - Frantz,Ivan D.

AU - Fiascone,John M.

AU - MacKinnon,Brenda L.

AU - Nylen,Ellen

AU - Carlo,Waldemar A.

AU - Ambalavanan,Namasivayam

AU - Collins,Monica V.

AU - Cosby,Shirley S.

AU - Devaskar,Uday

AU - Garg,Meena

AU - Chanlaw,Teresa

AU - Geller,Rachel

AU - Bell,Edward F.

AU - Ellsbury,Dan L.

AU - Widness,John A.

AU - Johnson,Karen J.

AU - Campbell,Donia B.

AU - Watterberg,Kristi L.

AU - Ohls,Robin K.

AU - Lacy,Conra Backstrom

AU - Montman,Rebecca A.

AU - Brown,Sandra

AU - Wussow,Theresa

AU - Hartenberger,Carol

AU - Schmidt,Barbara

AU - Kirpalani,Haresh

AU - DeMauro,Sara B.

AU - Chaudhary,Aasma S.

AU - Abbasi,Soraya

AU - Mancini,Toni

AU - Cucinotta,Dara M.

AU - D'Angio,Carl T.

AU - Guillet,Ronnie

AU - Lakshminrusimha,Satyan

AU - Reynolds,Ann Marie

AU - Reubens,Linda J.

AU - Jensen,Rosemary

AU - Maffett,Deana

AU - Wadkins,Holly I.M.

AU - Sacilowski,Michael G.

AU - Williams,Ashley

AU - Guilford,Stephanie

AU - Horihan,Cassandra A.

AU - Kennedy,Kathleen A.

AU - Tyson,Jon E.

AU - Burson,Katrina

AU - Harris,Beverly Foley

AU - McDavid,Georgia E.

AU - Pierce Tate,Patti L.

AU - Wright,Sharon L.

AU - Sánchez,Pablo J.

AU - Brion,Luc P.

AU - Chen,Lijun

AU - Guzman,Alicia

AU - Leps,Melissa H.

AU - Miller,Nancy A.

AU - Morgan,Janet S.

AU - Vasil,Diana M.

AU - Torres,Lizette E.

AU - Faix,Roger G.

AU - Yoder,Bradley A.

AU - Osborne,Karen A.

AU - Bird,Karie

AU - Burnett,Jill

AU - Jensen,Jennifer J.

AU - Spencer,Cynthia

AU - Weaver-Lewis,Kimberlee

AU - Zanetti,Karen

AU - Shankaran,Seetha

AU - Barks,John

AU - Bara,Rebecca

AU - Johnson,Mary

AU - Christensen,Mary

AU - Wiggins,Stephanie

AU - Ehrenkranz,Richard A.

AU - Jacobs,Harris

AU - Cervone,Patricia

AU - Konstantino,Monica

AU - Poulsen,Jo Ann

AU - Taft,Janet

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective To assess the association between prophylactic indomethacin and bronchopulmonary dysplasia (BPD) in a recent, large cohort of extremely preterm infants. Study design Retrospective cohort study using prospectively collected data for infants with gestational ages < 29 weeks or birth weights of 401-1000 g born between 2008 and 2012 at participating hospitals of the National Institute of Child Health and Human Development Neonatal Research Network. Infants treated with indomethacin in the first 24 hours of life were compared with those who were not. Study outcomes were BPD, defined as use of supplemental oxygen at 36 weeks postmenstrual age among survivors to that time point, death, and the composite of death or BPD. Prespecified subgroup analyses were performed. Results Prophylactic indomethacin use varied by hospital. Treatment of a patent ductus arteriosus after the first day of life was less common among 2587 infants who received prophylactic indomethacin compared with 5244 who did not (21.0% vs 36.1%, P < .001). After adjustment for potential confounders, use of prophylactic indomethacin was not associated with higher or lower odds of BPD (OR 0.89, 95% CI 0.72-1.10), death (OR 0.80, 95% CI 0.64-1.01), or death or BPD (OR 0.87, 95% CI 0.71-1.05). The only evidence of subgroup effects associated with prophylactic indomethacin were lower odds of death among infants with birth weights above the 10th percentile and those who were not treated for a patent ductus arteriosus after the first day of life. Conclusions Prophylactic indomethacin was not associated with either reduced or increased risk for BPD or death. Trial registration ClinicalTrials.gov: NCT00063063

AB - Objective To assess the association between prophylactic indomethacin and bronchopulmonary dysplasia (BPD) in a recent, large cohort of extremely preterm infants. Study design Retrospective cohort study using prospectively collected data for infants with gestational ages < 29 weeks or birth weights of 401-1000 g born between 2008 and 2012 at participating hospitals of the National Institute of Child Health and Human Development Neonatal Research Network. Infants treated with indomethacin in the first 24 hours of life were compared with those who were not. Study outcomes were BPD, defined as use of supplemental oxygen at 36 weeks postmenstrual age among survivors to that time point, death, and the composite of death or BPD. Prespecified subgroup analyses were performed. Results Prophylactic indomethacin use varied by hospital. Treatment of a patent ductus arteriosus after the first day of life was less common among 2587 infants who received prophylactic indomethacin compared with 5244 who did not (21.0% vs 36.1%, P < .001). After adjustment for potential confounders, use of prophylactic indomethacin was not associated with higher or lower odds of BPD (OR 0.89, 95% CI 0.72-1.10), death (OR 0.80, 95% CI 0.64-1.01), or death or BPD (OR 0.87, 95% CI 0.71-1.05). The only evidence of subgroup effects associated with prophylactic indomethacin were lower odds of death among infants with birth weights above the 10th percentile and those who were not treated for a patent ductus arteriosus after the first day of life. Conclusions Prophylactic indomethacin was not associated with either reduced or increased risk for BPD or death. Trial registration ClinicalTrials.gov: NCT00063063

KW - bronchopulmonary dysplasia

KW - extreme prematurity

KW - indomethacin

KW - prophylaxis

UR - http://www.scopus.com/inward/record.url?scp=85014020646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014020646&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2017.02.003

DO - 10.1016/j.jpeds.2017.02.003

M3 - Article

VL - 186

SP - 34-40.e2

JO - Journal of Pediatrics

T2 - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -