Apoptotic pathways in pemphigus

Research output: Contribution to journalReview article

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Abstract

Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.

LanguageEnglish (US)
Article number456841
JournalDermatology Research and Practice
Volume2010
Issue number1
DOIs
StatePublished - Jan 1 2010

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Pemphigus
Acantholysis
Apoptosis
Immunoglobulin G
Desmosomes
Cysteine Proteases
Cadherins
Blister
Caspases
Cell Adhesion
Autoantibodies
Autoimmune Diseases
Skin
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Apoptotic pathways in pemphigus. / Bektas, Meryem; Jolly, Puneet; Rubenstein, David S.

In: Dermatology Research and Practice, Vol. 2010, No. 1, 456841, 01.01.2010.

Research output: Contribution to journalReview article

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